Abstract: In a clinical decision support method, outputs of computer-implemented analytical modules are computed for a patient. Information is displayed for the patient pertaining to a clinical question comprising outputs computed for the patient of analytical modules associated with the clinical question. The analytical modules may include modules configured to perform in silico genetic/genomic tests using genetic/genome sequencing (whole genome, whole exome, whole transcriptome, targeted gene panels, etc) or microarray data. A clinical question-module matrix (CQ-M matrix) may be generated for the patient associating clinical questions with analytical modules, and the method may further include populating the clinical questions with outputs computed for the patient of the analytical modules associated with the clinical questions by the CQ-M matrix.

Abstract: A catalog (34) of molecular marker tests specifies molecular marker tests annotated with clinical applicability annotations. An electronic patient medical record (22) stores genetic sequencing data (20) of a patient. A clinical decision support (CDS) system (30) is configured to track the clinical context of the patient wherein the clinical context includes at least a disease diagnosis and a current patient care stage. A catalog search module (32) is configured to search the catalog of molecular marker tests to identify a molecular marker test having clinical applicability to the patient in the clinical context tracked by the CDS system. The search is automatically triggered by occurrence of a trigger event defined by a set of triggering rules. A testing module (44) is configured to perform a molecular marker test identified by the identification module in silico using the genetic sequencing data of the patient stored in the electronic patient medical record.

Abstract: This invention relates to a method and an apparatus for determining a reliability indicator for at least one set of signatures obtained from clinical data collected from a group of samples. The signatures are obtained by detecting characteristics in the clinical data from the group of sample sand each of the signatures generate a first set of stratification values that stratify the group of samples. At least one additional and parallel stratification source to the signatures obtained from group of sample sis provided, the at least one additional and parallel stratification source to the signatures being independent from the signatures and generates a second set of stratification values. A comparison is done for each respective sample, where the first stratification values are compared with a true reference stratification values, and where the second stratification values are compared with the true reference stratification values.

Abstract: The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement.

Abstract: The present invention relates to a method for stratifying a patient into a clinically relevant group comprising the identification of the probability of an alteration within one or more sets of molecular data from a patient sample in comparison to a database of molecular data of known phenotypes, the inference of the activity of a biological network on the basis of the probabilities, the identification of a network information flow probability for the patient via the probability of interactions in the network, the creation of multiple instances of network information flow for the patient sample and the calculation of the distance of the patient from other subjects in a patient database using multiple instances of the network information flow.

Abstract: A state machine (22) stores a current state (30) comprising a clinical context defined by available patient-related information relating to a medical patient, and identifies one or more available analytical tools of a set of analytical tools (24) that are applicable to the current state. A graphical user interface module (16) receives a user selection of an available analytical tool. The state machine loads patient-related information (40) to the user-selected available analytical tool (24sel) and invokes the user-selected available analytical tool to operate on the loaded patient-related information to generate additional patient-related information relating to the medical patient and/or graphical patient-related content relating to the medical patient. The state machine transitions from the current state (30) to a next state (30?) and/or invokes the graphical user interface module to display the graphical patient related content.

Abstract: The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said bio-medical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10,FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR.

Abstract: The present invention is directed to a method and system for retrieving information about television programs. This includes a website being connected to that includes information about a television program being watched. The information from the website is downloaded and then processed. Further, the information is then either displayed along with the television program being watched or stored for later playback.

Abstract: The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer disorders by determining the methylation status of one or more sequences according to SEQ ID NO: 1-111. The classification may be further strengthened by also taking the expression levels of one or more proteins into account.

Abstract: A method (10) for forming novel signatures of biological data is provided. The method comprises ranking features based on a trend value, which is created based on multiple signatures identified by a pattern discovery method. Furthermore, a device (30) and a computer program product (40), performing the steps according to the method (10) is provided. Uses of the method, for statistically analyzing clinical data, designing assays based on multiple molecular signatures and interpreting assays based on multiple molecular signatures are also provided.

Abstract: Provided is a method for the analysis of breast cancer disorders, comprising determining the genomic methylation status of one or more CpG dinucleotides. Furthermore, a computer program product stored on a computer-readable medium comprising software code adapted to perform the steps of the method when executed on a data-processing apparatus is provided. A device comprising means for supporting a clinician is also provided.

Abstract: The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer.

Abstract: This invention relates to a method and an apparatus for determining a reliability indicator for at least one set of signatures obtained from clinical data collected from a group of samples. The signatures are obtained by detecting characteristics in the clinical data from the group of sample sand each of the signatures generate a first set of stratification values that stratify the group of samples. At least one additional and parallel stratification source to the signatures obtained from group of sample sis provided, the at least one additional and parallel stratification source to the signatures being independent from the signatures and generates a second set of stratification values. A comparison is done for each respective sample, where the first stratification values are compared with a true reference stratification values, and where the second stratification values are compared with the true reference stratification values.

Abstract: A method for providing complementary information 226 for a video program is provided that includes receiving complementary information 226 for a video program. A query is received from a consumer. The query is related to a specified portion of the complementary information 226. A query response is provided to the consumer based on the specified portion of the complementary information 226.

Abstract: Image templates define characteristics of video content desired to be recorded, including color characteristics and spatial distribution of regions to be compared in determining a level of similarity and white regions of expected variability which are ignored in the comparison. Each image template is compared to fields for an associated channel, either continuously or during a predefined period. Fields received on the associated channel which have at least a threshold level of similarity are saved, together with associated audio.

Abstract: A content maintenance system uses a time-dependent precipitation function for iteratively augmenting or removing content over time, after an initial demonstration of user interest. A plurality of parallel precipitation processes can be launched simultaneously in response to different facets of a user expression of interest. Precipitation is dependent on highlighting or extracting segment descriptors from content of interest to the user. Then segments are filtered, rated, annotated and/or prioritized from that content. The remaining segments are matched against stored search structures. When the segments match, they are precipitated out for storage and can generate new search structures.

Abstract: A method and apparatus for determining a subset of measurements from a plurality of measurements in a genetic algorithm is disclosed. The method comprising the steps of determining a fitness measure for each sub-set of the measurements, wherein each measurement has an associated fitness measure and selecting the subset of measurements having the lowest fitness measure (110, 120). The method further comprises the steps of determining a cost function for each subset of measurements, wherein each measurement includes an associated cost and selecting the subset of measurements having the lowest cost function (150, 170).

Abstract: A method and apparatus for selecting measurements from a plurality of measurements is disclosed. The method includes the steps of initializing a measurement status to a first value for each of the measurements, determining selectability of one of the plurality of measurements based on a corresponding status value, and updating the status to a second value after selecting the measurement. In one aspect of the invention, the step of determining selectability further comprises the step of selecting one of the plurality of measurements, and retaining the selected measurement when the value of the corresponding status is the first value.

Abstract: A method and system for multi-authentication log-on control are provided. The method and system include two authentication mechanisms. The first one is a device that provides a physical key, and the other one is a proximity device, which identifies a user when in the proximity of a reader. These devices allow the user to log in to a computer system (100) effortlessly just by touching a reader with the physical key, and the user will be automatically logged off when they step away from the computer. A method includes the steps of verifying the user physically at the at least one terminal (340, 342); granting access to the at least one terminal if the user is verified (344); detecting the user within a predetermined distance of the at least one terminal (360); and logging off the user when the user is outside the predetermined distance (366).

Abstract: Content of multiple digital bit streams with essentially the same renderable content, and situated at mutually remote locations, are played back in unison. First, time is synchronized among the processors that participate in a synchronized viewing session by playing back respective streams. Second, the playbacks are content-wise aligned, by rewinding or fast forwarding, to effect overall a precisely synchronized presentation. The content-wise alignment is achieved by means of a status message between processors that contains information characteristic of the sender's bit stream. If any participant, performs a control function (e.g. rewind, fast forward, stop), all other participants follow synchronously. The processor that initiates the session is deemed the initiator, a role that is thereafter assumed by the participant that has last performed a control function.