Patent number: 4748175
Abstract: The invention relates to novel pyrimido [5,4-b][1,4]oxazine derivatives of the formula (I), and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein R.sup.1 stands for a C.sub.1-4 alkyl group;R.sup.2 stands for hydrogen or halogen or an azido group or an --NR.sup.5 R.sup.6 group, whereinR.sup.5 represents hydrogen or a benzyl group, or a C.sub.1-4 alkyl group unsubstituted or substituted by a hydroxyl group,R.sup.6 stands for hydrogen, an amino group, a C.sub.3-6 cycloalkyl group, a straight or branched-chain C.sub.1-4 alkyl group optionally substituted by a hydroxyl, mercapto, aminocarbonyl, furyl, 2-benzo[1,4]dioxanyl, di(C.sub.1-4 alkyl)amino group or by a phenyl or phenoxy group optionally mono- or polysubstituted by halogen or C.sub.1-4 alkoxy group (s) or by a 6-membered, saturated nitrogen-containing heterocycle optionally containing an additional nitrogen or oxygen atom and optionally substituted by a C.
Type:
Grant
Filed:
December 30, 1986
Date of Patent:
May 31, 1988
Assignee:
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt
Inventors:
Endre Kasztreiner, Gyorgy Rabloczky, Nandor Makk, Gyorgy Cseh, Maria Kuhar nee Kurthy, Eszter Diesler, Laszlo Jaszlits, Laszlo Sebestyen, Janos Wellmann, Aniko Tegdes, Judit Sarossy nee Kincsesy, Peter Matyus, Andras Varro, Laszlo Szam, Sarolta Vegvari nee Gyurki