Abstract: This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC—(CRR)m—COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2—SO3H, CH2—OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.

Abstract: The present invention relates to a method for cardiac development activity in a subject comprising administering to the subject an appropriate amount of perivitelline fluid obtained from fertilized eggs of horseshoe crab.

Abstract: A process for obtaining a substance with growth promoting activity that includes the step of isolating perivitelline fluid from a fertilized egg of a horseshoe crab. Also, a process for proliferating cells including the steps of isolating perivitelline fluid from a fertilized egg of a horseshoe crab and growing the cells in the presence of the isolated perivitelline fluid.

Abstract: The present invention relates to a process for the cure and control of Diabetes mellitus using natural products isolated from Perna viridis.

Abstract: The present invention relates to a method for cardiac development activity in a subject comprising administering to the subject an appropriate amount of perivitelline fluid obtained from fertilized eggs of horseshoe crab.

Abstract: The invention provides the use of phosphono derivatives of selected aliphatic acids represented by the structural formulae R—COOH, R being PO3H2 or CR1R2—PO3H2 where R1/R2 are H, OH, COOH or alkyl groups for the treatment of malaria. The use of the compound comprises administering an effective amount of said compounds for in vitro and in vivo studies using malarial parasites (Plasmodium falciparum and Plasmodium berghei).

Abstract: The invention provides a compositions comprising mussel hydrolysate from Indian green mussel, e.g., Perna viridis. The invention further provides methods of inhibiting or preventing osteoclast formation and/or bone resorption comprising administration of mussel hydrolysate from Indian Green to an animal or human. The compositions of the invention are non-toxic to other cells. Additionally, the invention provides processes for extracting mussel hydrolysate from Indian green mussel, e.g., Perna viridis.

Abstract: The invention provides the use of zinc complexes of selected amino acids from D or L isomers of proline, lysine, histidine, glycine, arginine and tryptophan or their various hydroxyl, amino, alkyl and carboxyl derivatives and zinc chloride, zinc acetate or other pharmacologically acceptable salts of zinc. The use of the compound comprises administering an effective amount of said compounds for inhibition of growth: of the malarial parasite, Plasmodium falciparum. The compound is lethal to the parasite in RBC cultures but have no effect on the RBCs. The compound has also displayed activity against, the chloroquine-resistant strain-W2Mef. The dose response curves for both 3D7 and W2Mef strains are identical which strongly suggested that the compound is equally effective against field isolates of chloroquine-resistant, P. falciparum. The compound acts on W2Mef strain through killing the target.

Abstract: The present invention is related to compounds having general formula Z-OC(CRn1Rn2)—CO-Z wherein Z=OH or NH2 and n1=n2=1 to 8, for modulation of immune response by differentiation dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR3R4—CR2(NHR1)—COOH, ZOC—CR5R6—CR3R4—C(NHR2)—COOH, ZOC—CR7R8—CR5R6—CR3R4—CR1(NHR2)—COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC—(CH2)n—CR1R2—COOH, where Z=OH or NH2; and n=1, 2, 3. The groups R1/R2=H/SO3H or OSO3H or CH2—SO3H or CH2—OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn.

Abstract: This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC—(CRR)m—COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2—SO3H, CH2—OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.

Abstract: The present invention is related to compounds having general formula Z-OC (CRn1Rn2)—CO-Z wherein Z=OH or NH2 and n1=n2=1 to 8, useful for modulation of immune response by inducing differentiation of dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR3R4—CR2(NHR1)—COOH, ZOC—CR5R6—CR3R4—CR1(NHR2)—COOH, ZOC—CR7R8—CR5R6—CR3R4—CR1N2)—COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC—(CH2)n—CR1R2—COOH, where Z=OH or NH2; and n=1, 2, 3. The groups R1/R2=H/SO3H or OSO3H or CH2—SO3H or CH2—OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn.

Abstract: An extract with antiviral activity including a mixture of extracts from Spatoglossum asperum., Padina tetrastromatica, Sargassum tenerrimum, and Stoechospermum marginatum. Also, a process for preparation of the extracts, and a method of treatment using the extracts.

Abstract: This invention relates to the identification and characterization of cell proliferating factor in the peri-vitalline fluid of the fertilized eggs of the Indian horseshoe crab.

Abstract: The present invention provides a process for large scale in vitro production of amoebocytes of Indian Horseshoe Crab (Tachypleus gigas) (T. gigas) from dissected gill flaps of T. gigas, in Leibovitz L-15 culture medium concentration (2×), to provide enhanced generation of amoebocytes. The process comprises the steps of: dissecting gill flaps of T. gigas; washing the gill flaps with an antibiotic solution followed by alcohol; culturing the gill flaps in tissue culture plates of sterile saline on a Rocker platform; culturing further the gill flaps in Leibovitz L-15 culture medium (2×); purging the gill flaps with Tween 80 solution; and purging again the gill flaps with horseshoe crab serum, while keeping the gill flaps in the culture medium viable for 90 days by feeding with fresh medium at an interval of 10-15 days to enable the enhanced release of amoebocytes both within and outside the gill flaps.

Abstract: The present invention relates to the use of Indian Green Mussel (Perna viridis) as a source of anti-HIV activity. More particularly, the present invention relates to the use of an extract of Indian Green Mussel (Perna viridis) as a source of anti-HIV activity in vitro.

Abstract: The present invention particularly relates to an extract from Indian green mussel (Pema viridis) which induces differentiation and maturation of dendritic cells wherein said dendritic cells can be used in vaccination, cancer therapy and other immunomodulatory regiments.

Abstract: The present invention provides a process for large scale in vitro production of amoebocytes of Indian Horseshoe Crab (Tachypleus gigas) from dissected gill flaps of T. gigas, in Leibovitz culture medium concentration (2×L-15), having enhanced generation of amoebocytes, said process comprising the steps of: dissecting gill flaps of T. gigas; washing the gill flaps with an antibiotic solution followed by alcohol; culturing the gill flaps in tissue culture plates of sterile saline on a Rocker platform; culturing further the gill flapsin Leibovitz culture medium (2×L-15); purging the gill flaps with Tween 80 solution; and purging again the gill flaps with horse crab serum, keeping the culture viable for 90 days by feeding with fresh medium at an interval of 10-15 days to enable the enhanced release of amoebocytes both within and outside the gill flaps.

Abstract: The invention provides a compositions comprising mussel hydrolysate from Indian green mussel, e.g., Perna viridis. The invention further provides methods of inhibiting or preventing osteoclast formation and/or bone resorption comprising administration of mussel hydrolysate from Indian Green to an animal or human. The compositions of the invention are non-toxic to other cells. Additionally, the invention provides processes for extracting mussel hydrolysate from Indian green mussel, e.g., Perna viridis.

Abstract: This invention relates to the identification and characterization of cell proliferating factor in the peri-vatalline fluid of the fertilized eggs of the Indian horseshoe crab.

Abstract: The present invention relates to a process for the cure and control of Diabetes mellitus using natural products isolated from Perna viridis.