Patents by Inventor Anjana Bhuta Wills
Anjana Bhuta Wills has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8251958Abstract: A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.Type: GrantFiled: December 10, 2010Date of Patent: August 28, 2012Assignee: Becton, Dickinson and CompanyInventors: Vincent J. Sullivan, Ronald J. Pettis, John A. Mikszta, John P. Dekker, III, Wendy D. Woodley, Anjana Bhuta Wills, Matthew S. Ferriter, C. Robin Hwang
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Publication number: 20110251546Abstract: A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.Type: ApplicationFiled: December 10, 2010Publication date: October 13, 2011Inventors: Vincent J. Sullivan, Ronald J. Pettis, John A. Mikszta, John P. Dekker, III, Wendy D. Woodley, Anjana Bhuta Wills, Matthew S. Ferriter, C. Robin Hwang
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Patent number: 7896836Abstract: A valved medicament delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament delivery device of this invention may be utilized to deliver a controlled unit dose of a medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.Type: GrantFiled: April 12, 2006Date of Patent: March 1, 2011Assignee: Becton, Dickinson and CompanyInventors: Vincent J. Sullivan, Anjana Bhuta Wills
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Patent number: 7850663Abstract: A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.Type: GrantFiled: June 1, 2004Date of Patent: December 14, 2010Assignee: Becton, Dickinson and CompanyInventors: Vincent J. Sullivan, Ronald J. Pettis, John A. Mikszta, John P. Dekker, III, Wendy D. Woodley, Anjana Bhuta Wills, Matthew S. Ferriter, C. Robin Hwang
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Patent number: 7842310Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35? and about 300?, and/or the powder comprises dried particles having an average mean diameter of between about 35? and about 300?. Compositions made by the above methods, and methods of using the compositions, are also described.Type: GrantFiled: November 19, 2002Date of Patent: November 30, 2010Assignee: Becton, Dickinson and CompanyInventors: Robin Hwang, Vincent Sullivan, Juan Huang, Zhaolin Wang, John A. Mikszta, David Montgomery, Brandi Ford, Anjana Bhuta-Wills
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Patent number: 7644562Abstract: A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet.Type: GrantFiled: March 18, 2005Date of Patent: January 12, 2010Assignee: Becton, Dickinson and CompanyInventors: Vincent J. Sullivan, Lawrence A. Monahan, Christopher J. Knors, Anjana Bhuta Wills, Michael W. Trull
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Patent number: 7270127Abstract: A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.Type: GrantFiled: September 3, 2002Date of Patent: September 18, 2007Assignee: Becton, Dickinson and CompanyInventors: Artis R. Lockhart, Vincent J. Sullivan, Lawrence A. Monahan, Anjana Bhuta Wills
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Publication number: 20070190158Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35? and about 300?, and/or the powder comprises dried particles having an average mean diameter of between about 35? and about 300?. Compositions made by the above methods, and methods of using the compositions, are also described.Type: ApplicationFiled: March 26, 2007Publication date: August 16, 2007Applicant: Becton Dickinson and CompanyInventors: Robin Hwang, Vincent Sullivan, Juan Huang, Zhaolin Wang, John Mikszta, David Montgomery, Brandi Ford, Anjana Bhuta-Wills
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Patent number: 7051734Abstract: A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.Type: GrantFiled: October 14, 2003Date of Patent: May 30, 2006Assignee: Becton Dickinson and CompanyInventors: Robert A. Casper, John M. Snow, David L. Gardner, Vincent J. Sullivan, Anjana Bhuta Wills, Lawrence A. Monahan, Christopher J. Knors
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Patent number: 6929005Abstract: A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet.Type: GrantFiled: June 12, 2001Date of Patent: August 16, 2005Assignee: Becton, Dickinson and CompanyInventors: Vincent J. Sullivan, Anjana Bhuta Wills, Lawrence A. Monahan, Michael W. Trull, Christopher J. Knors
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Publication number: 20040079363Abstract: A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.Type: ApplicationFiled: October 14, 2003Publication date: April 29, 2004Inventors: Robert A. Casper, John M. Snow, David L. Gardner, Vincent J. Sullivan, Anjana Bhuta Wills, Lawrence A. Monahan, Christopher J. Knors
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Patent number: 6644309Abstract: A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.Type: GrantFiled: September 10, 2001Date of Patent: November 11, 2003Assignee: Becton, Dickinson and CompanyInventors: Robert A. Casper, John M. Snow, David L. Gardner, Vincent J. Sullivan, Anjana Bhuta Wills, Lawrence A. Monahan, Christopher J. Knors
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Publication number: 20030186271Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35&mgr; and about 300&mgr;, and/or the powder comprises dried particles having an average mean diameter of between about 35&mgr; and about 300&mgr;.Type: ApplicationFiled: November 19, 2002Publication date: October 2, 2003Inventors: Robin Hwang, Vincent Sullivan, Juan Huang, Zhaolin Wang, John A. Mikszta, David Montgomery, Brandi Ford, Anjana Bhuta-Wills
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Publication number: 20030180755Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35&mgr; and about 300&mgr;, and/or the powder comprises dried particles having an average mean diameter of between about 35&mgr; and about 300&mgr;.Type: ApplicationFiled: November 19, 2002Publication date: September 25, 2003Inventors: Robin Hwang, Vincent Sullivan, Juan Huang, Zhaolin Wang, John A. Mikszta, David Montgomery, Brandi Ford, Anjana Bhuta-Wills
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Publication number: 20030047184Abstract: A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.Type: ApplicationFiled: September 3, 2002Publication date: March 13, 2003Inventors: Artis R. Lockhart, Vincent J. Sullivan, Lawrence A. Monahan, Anjana Bhuta Wills
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Patent number: 6443152Abstract: A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.Type: GrantFiled: June 12, 2001Date of Patent: September 3, 2002Assignee: Becton Dickinson and CompanyInventors: Artis R. Lockhart, Vincent J. Sullivan, Lawrence A. Monahan, Anjana Bhuta Wills
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Publication number: 20020092524Abstract: A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.Type: ApplicationFiled: June 12, 2001Publication date: July 18, 2002Applicant: Becton Dickinson and CompanyInventors: Artis R. Lockhart, Vincent J. Sullivan, Lawrence A. Monahan, Anjana Bhuta Wills
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Publication number: 20020092521Abstract: A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet.Type: ApplicationFiled: June 12, 2001Publication date: July 18, 2002Applicant: Becton Dickinson and CompanyInventors: Vincent J. Sullivan, Anjana Bhuta Wills, Lawrence A. Monahan, Michael W. Trull, Christopher J. Knors
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Publication number: 20020092520Abstract: A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.Type: ApplicationFiled: September 10, 2001Publication date: July 18, 2002Inventors: Robert A. Casper, John M. Snow, David L. Gardner, Vincent J. Sullivan, Anjana Bhuta Wills, Lawrence A. Monahan, Christopher J. Knors