Patents by Inventor Anjana Rao

Anjana Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEASURING A LEVEL OF A 5-HYDROXYMETHYLCYTOSINE IN A SAMPLE FROM A SUBJECT HAVING A CANCER OR SUSPECTED OF HAVING CANCER
    Publication number: 20180120304
    Abstract: Provided herein are methods and kits for measuring a level of a 5-hydroxymethylcytosine in a nucleotide sequence from a subject, wherein the subject is a subject having a cancer or suspected of having cancer.
    Type: Application
    Filed: February 23, 2017
    Publication date: May 3, 2018
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servi
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20180119113
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: February 23, 2017
    Publication date: May 3, 2018
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servi
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • DETECTING 5-HYDROXYMETHYLATED CYTOSINE
    Publication number: 20180119225
    Abstract: Provided herein are methods and kits for detecting 5-hydroxymethylated cytosine.
    Type: Application
    Filed: February 23, 2017
    Publication date: May 3, 2018
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servic
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • Regulators of NFAT
    Patent number: 9932378
    Abstract: Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: April 3, 2018
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Anjana Rao, Stefan Feske, Patrick Hogan, Yousang Gwack
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20180044633
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 15, 2018
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servic
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20180044632
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 15, 2018
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servic
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • Detection of 5-hydroxymethylcytosine by glycosylation
    Patent number: 9816986
    Abstract: Provided herein are methods and kits for detecting a modified cytosine.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: November 14, 2017
    Assignee: Children's Medical Center Corporation
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20170219589
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: April 10, 2017
    Publication date: August 3, 2017
    Applicants: The Children's Medical Center Corporation, The U.S.A., As Represented by the Secretary, Department of Health & Human Services
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20170218338
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: April 10, 2017
    Publication date: August 3, 2017
    Applicants: The Children's Medical Center Corporation, The U.S.A., As Represented by the Secretary, Department of Health & Human Services
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20170191119
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: November 2, 2016
    Publication date: July 6, 2017
    Applicants: Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Ser.
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20170176421
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 22, 2017
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servic
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20170175085
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 22, 2017
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servic
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20170176420
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 22, 2017
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servic
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20170168043
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 15, 2017
    Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human Servic
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
    Publication number: 20170145484
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Application
    Filed: June 27, 2016
    Publication date: May 25, 2017
    Applicants: Children's Medical Center Corporation
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • Regulators of NFAT and/or store-operated calcium entry
    Patent number: 9567580
    Abstract: Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of septin 4 (SEPT 4) and septin 5 (SEPT 5) proteins involved in the calcineurin/NFAT axis and T-cell activation.
    Type: Grant
    Filed: October 10, 2011
    Date of Patent: February 14, 2017
    Inventors: Anjana Rao, Patrick Hogan, Sonia Sharma
  • HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF
    Publication number: 20160317498
    Abstract: The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications.
    Type: Application
    Filed: March 8, 2016
    Publication date: November 3, 2016
    Applicants: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Tracy Keller, Ralph Mazitschek, Malcolm Whitman, Jinbo Lee, Mark S. Sundrud, Anjana Rao
  • Selective oxidation of 5-methylcytosine by TET-family proteins
    Patent number: 9447452
    Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: September 20, 2016
    Assignees: Children's Medical Center Corporation, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
  • Halofuginone analogs for inhibition of tRNA synthetases and uses thereof
    Patent number: 9284297
    Abstract: The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: March 15, 2016
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Tracy Keller, Ralph Mazitschek, Malcolm Whitman, Jinbo Lee, Mark S. Sundrud, Anjana Rao
  • Regulators of NFAT and/or store-operated calcium entry
    Patent number: 9271997
    Abstract: Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of proteins involved in the calcineurin/NFAT axis.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: March 1, 2016
    Assignee: THE CHILDREN'S HOSPITAL CORPORATION
    Inventors: Anjana Rao, Patrick Hogan, Sonia Sharma