Abstract: Systems, devices, and methods are provided for delivering chemical and electrical stimulation across one or more neural circuits. The systems, devices, and methods can also be used for sensing and recording specific neural activity. In certain embodiments, a system includes first and second fluid reservoirs, a manifold, and a delivery tube. The manifold may include first and second chambers therein. The first chamber may be in fluid communication with the first reservoir, and the second chamber may be in fluid communication with the second reservoir. The delivery tube may include a first conduit in fluid communication with the first chamber, a second conduit in fluid communication with the second chamber, and a third conduit configured to house an electrode therein. In this manner, a distal tip of the delivery tube is configured to be positionable adjacent to the one or more neural circuits for providing chemical and electrical stimulation thereto.

Abstract: Systems, devices, and methods are provided for delivering chemical and electrical stimulation across one or more neural circuits. The systems, devices, and methods can also be used for sensing and recording specific neural activity. In certain embodiments, a system includes first and second fluid reservoirs, a manifold, and a delivery tube. The manifold may include first and second chambers therein. The first chamber may be in fluid communication with the first reservoir, and the second chamber may be in fluid communication with the second reservoir. The delivery tube may include a first conduit in fluid communication with the first chamber, a second conduit in fluid communication with the second chamber, and a third conduit configured to house an electrode therein. In this manner, a distal tip of the delivery tube is configured to be positionable adjacent to the one or more neural circuits for providing chemical and electrical stimulation thereto.

Abstract: In a system for unsupervised spike sorting, features/dimensions suitable for clustering of the recorded spike signal data are identified, and the feature space is scaled according to the computed respective importances of the various features/dimensions. Clustering is performed on the scaled feature space.

Abstract: The invention provides methods and apparatuses for monitoring task engagement by measuring beta frequency oscillations in the brain. Changes in power, frequency, and/or coherency of beta frequency oscillations correlate to an individual's engagement in or disengagement from a task. Accordingly, beta frequency oscillations can be used to determine if an individual prematurely disengages from a task, to diagnose if a person has a disorder affecting task engagement, and to evaluate the efficacy of a treatment for a disorder.

Abstract: The invention relates generally to the use of protein inhibitors in the treatment of diseases and disorders associated with undesired thrombosis. Inhibiting activation of the protein encoded by the CalDAG-GEFI gene results in the reduction or prevention of blood clot formation. The invention provides methods and agents for inhibiting CalDAG-GEFI protein activity for use in antithrombotic therapy.