Patents by Inventor Ann MeeJin Ferrie

Ann MeeJin Ferrie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200255783
    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 13, 2020
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Lori E. Romeo
  • Publication number: 20200248120
    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 6, 2020
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Lori E Romeo
  • Publication number: 20200248121
    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 6, 2020
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Lori E Romeo
  • Publication number: 20200248123
    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 6, 2020
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Lori E. Romeo
  • Publication number: 20200248122
    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 6, 2020
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Lori E. Romeo
  • Publication number: 20200248124
    Abstract: A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 6, 2020
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Lori E. Romeo
  • Publication number: 20200148989
    Abstract: A cell culture vessel (100) has walls and a substrate having a plurality of microcavities (120), where each microcavity of the plurality of microcavities includes a concave well and an opening to allow the microcavity to be filled with liquid. A flange (170) surrounds the substrate having an array of microcavities. A channel (175, 176) surrounds the flange, providing a moat around the microcavity substrate. The flange is angled. Methods of culturing cells in the cell culture vessel are also provided.
    Type: Application
    Filed: July 13, 2018
    Publication date: May 14, 2020
    Applicant: CORNING INCORPORATED
    Inventors: Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Jeffrey Glenn Lynn
  • Publication number: 20190322969
    Abstract: The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.
    Type: Application
    Filed: June 20, 2019
    Publication date: October 24, 2019
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Gregory Roger Martin, Kaitlyn Mary Matias, Michael Kurt Schaefer, Allison Jean Tanner
  • Publication number: 20190326039
    Abstract: Magnetic particles have a particle size of 500 nm of less and include a core and a polymer coating that surrounds and encapsulates the core. The core includes a metal, metal alloy, or metal oxide of at least one metal such as B, Mg, Al, Mn, Co, Ni, Cu, Fe Sm, Ln, Yb, Dy, Gd or Er and Nb. The magnetic core is polycrystalline particles which are superspin glass magnetic materials having coercivity greater than zero and magnetic remenance greater than zero at room temperature. Magnetic moment of these superspin glass magnetic materials at low field show increasing with temperature over room temperature. An in situ hydrolysis/precipitation method from precursor metal salts is used to form the polymer-encapsulated magnetic particles.
    Type: Application
    Filed: April 23, 2019
    Publication date: October 24, 2019
    Inventors: Ann MeeJin Ferrie, Yan Jin, Lingyan Wang, Yue Zhou
  • Patent number: 10319502
    Abstract: Magnetic particles (100) have a particle size (134) of 500 nm or less and include a core (110) and a polymer coating (120) that surrounds and encapsulates the core (110). The core (110) includes a metal, metal alloy, or metal oxide of at least one metal such as B, Mg, Al, Mn, Co, Ni, Cu, Fe Sm, Yb, Dy, Gd or Er and Nb. The magnetic core (100) is a polycrystalline particle and is a superspin glass magnetic material, having a coercivity greater than zero and a magnetic remenance greater than zero at room temperature. Above room temperature and at low field, the magnetic moment of these superspin glass magnetic materials increases with temperature. An in situ hydrolysis/precipitation method from precursor metal salts is used to form the polymer-encapsulated magnetic particles (100).
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: June 11, 2019
    Assignee: Corning Incorporated
    Inventors: Ann MeeJin Ferrie, Yan Jin, Lingyan Wang, Yue Zhou
  • Patent number: 10203320
    Abstract: A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: February 12, 2019
    Assignee: Corning Incorporated
    Inventors: Oberon Denaci Deichmann, Ye Fang, Ann MeeJin Ferrie, David Henry, Haibei Hu, Corinne Walerack, Qi Wu
  • Publication number: 20180151278
    Abstract: Magnetic particles (100) have a particle size (134) of 500 nm or less and include a core (110) and a polymer coating (120) that surrounds and encapsulates the core (110). The core (110) includes a metal, metal alloy, or metal oxide of at least one metal such as B, Mg, Al, Mn, Co, Ni, Cu, Fe Sm, Yb, Dy, Gd or Er and Nb. The magnetic core (100) is a polycrystalline particle and is a superspin glass magnetic material, having a coercivity greater than zero and a magnetic remenance greater than zero at room temperature. Above room temperature and at low field, the magnetic moment of these superspin glass magnetic materials increases with temperature. An in situ hydrolysis/precipitation method from precursor metal salts is used to form the polymer-encapsulated magnetic particles (100).
    Type: Application
    Filed: October 23, 2015
    Publication date: May 31, 2018
    Inventors: Ann MeeJin Ferrie, Yan Jin, Lingyan Wang, Yue Zhou
  • Patent number: 9976230
    Abstract: A crystallized layer can be formed on a substrate from a precursor layer deposited on a surface of the substrate. The precursor layer can be an oxide, a nitride, a carbide, or an oxynitride. The process for forming the crystallized layer includes melting the precursor layer formed on the surface of the substrate by localized topical heating of the precursor layer and then cooling the melted precursor layer so that it crystallized to form a scratch resistant crystallized layer. The scratch resistant crystallized layer can have a hardness of 15 GPa or greater.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: May 22, 2018
    Assignee: CORNING INCORPORATED
    Inventors: Glen Bennett Cook, Ann MeeJin Ferrie, Shawn Michael O'Malley, Vitor Marino Schneider
  • Publication number: 20180051247
    Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
    Type: Application
    Filed: December 16, 2015
    Publication date: February 22, 2018
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikoleavich Goral, David Henry, Martial Hervy, Corinne walerack, Yue Zhou
  • Publication number: 20170342363
    Abstract: The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.
    Type: Application
    Filed: April 20, 2017
    Publication date: November 30, 2017
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Gregory Roger Martin, Kaitlyn Mary Matias, Michael Kurt Schaefer, Allison Jean Tanner
  • Publication number: 20170226455
    Abstract: A cell culture apparatus may include a substrate defining a well. The well may define an interior surface, an exterior surface, an upper aperture and a nadir. The substrate may define a thickness between the interior and exterior surfaces that has a thickness proximate the nadir that is greater than or equal to a thickness proximate the upper aperture.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Allison Jean Tanner, Qi Wu
  • Publication number: 20160145600
    Abstract: Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media.
    Type: Application
    Filed: November 24, 2015
    Publication date: May 26, 2016
    Inventors: Stephen Joseph Caracci, Ye Fang, Ann MeeJin Ferrie, Yan Jin, Lingyan Wang, Yue Zhou
  • Publication number: 20160083863
    Abstract: A crystallized layer can be formed on a substrate from a precursor layer deposited on a surface of the substrate. The precursor layer can be an oxide, a nitride, a carbide, or an oxynitride. The process for forming the crystallized layer includes melting the precursor layer formed on the surface of the substrate by localized topical heating of the precursor layer and then cooling the melted precursor layer so that it crystallized to form a scratch resistant crystallized layer. The scratch resistant crystallized layer can have a hardness of 15 GPa or greater.
    Type: Application
    Filed: September 14, 2015
    Publication date: March 24, 2016
    Inventors: Glen Bennett Cook, Ann MeeJin Ferrie, Shawn Michael O'Malley, Vitor Marino Schneider
  • Publication number: 20150275167
    Abstract: An ex vivo cell culture sustained release composition, including: a mixture comprising: a sustenant; and a non-biodegradable binder; and a non-biodegradable and water insoluble encapsulant coat that encapsulates the mixture, as defined herein. Also disclosed is a method for sustainably providing a sustenant to a cell culture in aqueous media, including contacting a cell culture with the sustained release composition.
    Type: Application
    Filed: March 20, 2015
    Publication date: October 1, 2015
    Inventors: Ronald Allen Faris, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, Gregory Roger Martin, Jin Liu
  • Publication number: 20150268222
    Abstract: A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.
    Type: Application
    Filed: November 15, 2013
    Publication date: September 24, 2015
    Inventors: Oberon Denaci Deichmann, Ye Fang, Ann MeeJin Ferrie, Haibei Hu, Qi Wu