Patents by Inventor Anna Waterhouse
Anna Waterhouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11919971Abstract: This disclosure provides, e.g., methods for coupling Formation of Surface Carboxylates on PES an entity to a solid substrate. The method can comprise treating the with Exposure Time substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.Type: GrantFiled: May 16, 2017Date of Patent: March 5, 2024Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Daniel Christopher Leslie, Thomas Doyle, Anna Waterhouse, Melissa Rodas, Alexander L. Watters, Michael Super, Donald E. Ingber
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Publication number: 20190144567Abstract: This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.Type: ApplicationFiled: May 16, 2017Publication date: May 16, 2019Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Daniel Christopher LESLIE, Thomas DOYLE, Anna WATERHOUSE, Melissa RODAS, Alexander L. WATTERS, Michael SUPER, Donald E. INGBER
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Patent number: 10245355Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.Type: GrantFiled: July 10, 2014Date of Patent: April 2, 2019Assignee: President and Fellows of Harvard CollegeInventors: Donald Ingber, Daniel C. Leslie, Michael Super, Alexander L. Watters, Anna Waterhouse
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Publication number: 20180185839Abstract: A microfluidic coagulation assessment device includes a plurality of microchannels, with a blood sample driven through the microchannels at a substantially constant flow rate. A controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom.Type: ApplicationFiled: January 4, 2018Publication date: July 5, 2018Inventors: Abhishek Jain, Anna Waterhouse, Mike Super, Donald E. Ingber, Daniel C. Leslie
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Publication number: 20170100714Abstract: A microfluidic coagulation assessment device includes a plurality of microchannels, with a blood sample driven through the microchannels at a substantially constant flow rate. A controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom.Type: ApplicationFiled: December 29, 2016Publication date: April 13, 2017Inventors: Abhishek Jain, Anna Waterhouse, Mike Super, Donald E. Ingber, Daniel C. Leslie
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Patent number: 9562914Abstract: In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate.Type: GrantFiled: October 16, 2014Date of Patent: February 7, 2017Assignee: President and Fellows of Harvard CollegeInventors: Abhishek Jain, Anna Waterhouse, Mike Super, Donald E. Ingber, Daniel C. Leslie
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Publication number: 20160258968Abstract: In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate.Type: ApplicationFiled: October 16, 2014Publication date: September 8, 2016Inventors: Abhishek Jain, Anna Waterhouse, Mike Super, Donald E. Ingber, Daniel C. Leslie
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Publication number: 20160144079Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.Type: ApplicationFiled: July 10, 2014Publication date: May 26, 2016Inventors: Donald INGBER, Daniel C. LESLIE, Michael SUPER, Alexander L. WATTERS, Anna WATERHOUSE
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Publication number: 20150173883Abstract: Articles, methods of making, and uses for modifying surfaces for simultaneously providing repellency and selective binding of desired moieties are disclosed. The repellant surfaces comprise a substrate and a lubricating layer immobilized over the substrate surface having a lubricating liquid having an affinity with the substrate. The substrate and the lubricating liquid are attracted to each other together by non-covalent attractive forces. The repellent surface further includes a binding group extending over the surface of the lubricating layer and the binding group has an affinity with a target moiety. The lubricating layer and the substrate form a slippery or repellent surface configured and arranged for contact with a material that is immiscible with the lubricating liquid and the immiscible material contains the target moiety.Type: ApplicationFiled: July 12, 2013Publication date: June 25, 2015Applicant: President and Fellows of Harvard CollegeInventors: Donald Ingber, Michael Super, Daniel C. Leslie, Tohid Didar, Alexander L. Watters, Julia Bellows Berthet, Anna Waterhouse
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Publication number: 20140342954Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has a head group that is covalently linked to, or adsorbed onto, the surface and a functional group. The functional group of the treated surface has an affinity for a lubricating layer, which is applied to the treated surface. The anchoring layer and replenishable lubricating layer are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.Type: ApplicationFiled: January 10, 2013Publication date: November 20, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald Ingber, Daniel C. Leslie, Alexander L. Watters, Michael Super, Joanna Aizenberg, Michael Aizenberg, Philseok Kim, Anna Waterhouse
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Patent number: 8808365Abstract: Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate.Type: GrantFiled: January 6, 2010Date of Patent: August 19, 2014Inventors: Martin Kean Chong Ng, Anna Waterhouse, Anthony Steven Weiss, Steven Garry Wise
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Publication number: 20100174351Abstract: Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate.Type: ApplicationFiled: January 6, 2010Publication date: July 8, 2010Inventors: Martin Kean Chong Ng, Anna Waterhouse, Anthony Steven Weiss, Steven Garry Wise