Abstract: A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Abstract: Compositions for treating cancer comprising an amount of a camptothecin with a 7-ring ?-hydroxy lactone ring of the formula wherein the substituents are defined as in the specification sufficient to treat cancer.

Abstract: A method of treating cardiac rhythm disorders linked with neurodegenerating depression, bipolar disorders and irritable bowel disorders in warm-blooded animals in need thereof by administering a compound of the formula wherein the substituents are defined as in the specification.

Abstract: The invention concerns the use of pyrido-thieno-triazolo-diazepins for preparing a medicine for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors. The invention also concerns novel pyrido-thieno-triazolo-diazepins and therapeutic compositions containing them.

Abstract: The invention concerns compounds of general formula (1) wherein R1 represents H, alkyl,cycloalkyl or cycloalkylalkyl and R2 represents H or alkyl; R3 represents H, alkyl or aralkyl; X represents a bond or a linear or branched alkylene radical (II); Y represents H, cycloalkyl, OR14, SR15, NR4R5 or A represents a bond or phenyl; B and B? are independently selected among alkyl, NR6R7, SR8 and carbocyclic aryl orheterocyclic aryl radicals with five or six members optionally substituted; R4 represents H, alkyl, aryl, cycloalkyl, cycloalkylalkyl, aralkyl, C(O)R9, C(O)OR9, —C(O)NHR9 or —SO2R9, or further aryl or aralkyl whereof the aromatic ring is optionally substituted and R5 represents in particular H or alkyl, or further R, and R5 form with the nitrogen atom bearing them a non-aromatic hetcrocycle of five to seven members optionally substituted; R6 represents (in particular) II or alkyl and R7 represents (in particular) II or alkyl; R8 represents an alkyl radical optionally substituted; R9 represents alkyl, halo

Abstract: A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Abstract: Compositions for treating cancer comprising an amount of a camptothecin with a 7-ring &bgr;-hydroxy lactone ring of the formula 1

Abstract: A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Abstract: The invention relates to compounds of general formula (I) where R1=an alkyl, cycloalkylalkyl or aralkyl group optionally substituted on the aryl group; R2=a phenyl group, or R2=an optionally substituted biphenyl group and R3=H or alkyl and the pharmaceutically acceptable salts thereof. The above may be used for the production of a medicament for modulating sodium channels and in particular for treatment of pain (for example, neuropathic pain), epilepsy, neurodegenerative conditions and bipolar conditions.

Abstract: A method of treating a cancer in warm-blooded animals by administration to the warm-blooded animals in need thereof a camptothecin analog a 7-ring member &bgr;-hydroxy lactone ring of the formula wherein the substituents are defined as in the specification.

Abstract: The present invention relates to novel pyrido-thieno-diazepines, their preparation process and the pharmaceutical compositions containing them.

Abstract: A process for the preparation of a compound of the formula wherein the substituents are defined as set forth in the specification comprising reacting a compound of the formula with a 2-halo-3-quinoline-methanol of the formula to obtain a compound of the formula which is then cyclized to form the compound of Formula I.

Abstract: The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) 1

Abstract: The invention concerns novel sodium channel modulators derived from 2-piperidylimidazoles. The inventive compounds correspond to the general formula (I), wherein: R1 represents a hydrogen atom or an —X—Y—R4 radical wherein —X—Y represents a bond, a —CO—, —CO—O——CO—NH— or —CS—NH— radical and R4 represents an alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl radical, said radicals being optionally substituted; R2 represents in particular an alkyl, cycloalkyl, cycloalkylalkyl or aryl radical optionally substituted; and R3 represents a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, or aryl radical optionally substituted.

Abstract: A compound of the formula 1

Abstract: A process for the preparation of a compound of the formula 1

Abstract: The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.