Abstract: Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

Abstract: Methods and systems for preparing a medium-embedded-sample-block. The method comprises obtaining a frame having a plurality of sample wells arranged as a two-dimensional array, the frame having an open face for accessing the sample in the sample wells; placing embedding medium in the sample wells such that the embedding medium immerses the samples in the plurality of sample wells; allowing the embedding medium to form a block of embedding medium including the samples embedded therein; and separating the frame from the block of embedding medium to obtain the medium-embedded-sample-block.

Abstract: Methods and systems for preparing a medium-embedded-sample-block. The method comprises obtaining a frame having a plurality of sample wells arranged as a two-dimensional array, the frame having an open face for accessing the sample in the sample wells; placing embedding medium in the sample wells such that the embedding medium immerses the samples in the plurality of sample wells; allowing the embedding medium to form a block of embedding medium including the samples embedded therein; and separating the frame from the block of embedding medium to obtain the medium-embedded-sample-block.

Abstract: Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

Abstract: Methods and systems for preparing a medium-embedded-sample-block. The method comprises obtaining a frame having a plurality of sample wells arranged as a two-dimensional array, the frame having an open face for accessing the sample in the sample wells; placing embedding medium in the sample wells such that the embedding medium immerses the samples in the plurality of sample wells; allowing the embedding medium to form a block of embedding medium including the samples embedded therein; and separating the frame from the block of embedding medium to obtain the medium-embedded-sample-block.

Abstract: A method comprising: providing a biological sample from a subject (subject sample); and detecting the expression level of each of the markers FGF-2 and CA125 in the subject sample. A kit comprising means for detection of an expression level of each of markers CA125 and FGF-2 in a biological sample from a subject (subject sample), and instructions to use said markers in a method of the present invention.

Abstract: The present invention concerns a method of prognosing the risk of early ovarian cancer relapse in a subject having ovarian cancer comprising: a) detecting the level of at least one marker selected from the group consisting of BTF4, GCS and HLA-DRbeta1; and b) comparing the level of the above at least one marker with that of a corresponding control sample, wherein the detection of a lower level of the at least one marker compared to that in the control sample is indicative that the subject is at risk of early cancer relapse. Also provided is a method of stratifying a subject suffering from ovarian cancer based on the expression levels of the disclosed markers and kits for practicing the methods of the present invention.

Abstract: A method for the diagnosis of ovarian cancer comprising providing a biological sample from a subject (subject sample), and detecting the expression level of each of the markers FGF-2, CA 125 and IL-18 in the subject sample A kit comprising means for detection of an expression level of each of the markers CA 125, FGF-2 and IL-18 in a biological sample from a subject (subject sample), and instructions to use said markers in a method of the present invention.

Abstract: A method for predicting whether a patient suffering from a prostate cancer is at risk of experiencing a cancer progression or recurrence which comprises the steps of : obtaining a Gleason score of said prostate tumor sample; assessing the proportion of NF-kB localized in the nuclei of said tumor sample with regard to all NF-kB present in said tumor sample.

Abstract: The present invention relates to primary cultures or established cell lines of ovarian epithelium origin which are substantially equivalent to the cells from the original clinical material from which they are derived and can serve as a powerful model in numerous types of studies including the elaboration of a patient-based tumor profile, thereby permitting a more precise and personalized design of an efficacious therapeutic regimen for cancer therapy. The invention further relates to a method to derive primary cell cultures from benign and malignant ovarian tissue and from ascites.