Patents by Inventor Anne R. Kopf-Sill

Anne R. Kopf-Sill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apparatus and methods for correcting for variable velocity in microfluidic systems
    Patent number: 6703205
    Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: March 9, 2004
    Assignee: Caliper Technologies Corp.
    Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Claudia B. Cohen, Steven A. Sundberg, John Wallace Parce
  • High throughput screening assay systems in microscale fluidic devices
    Publication number: 20040028567
    Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
    Type: Application
    Filed: August 7, 2003
    Publication date: February 12, 2004
    Applicant: Caliper Technologies Corp.
    Inventors: J. Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
  • Microfluidic viscometer
    Patent number: 6681616
    Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: January 27, 2004
    Assignee: Caliper Technologies Corp.
    Inventors: Michael Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill
  • Ultra high throughput sampling and analysis systems and methods
    Publication number: 20040014239
    Abstract: Ultra-high throughput systems and methods are used for sampling large numbers of different materials from surfaces of substantially planar library storage components. The systems and methods typically employ: microfluidic devices having integrated capillary elements for carrying out the analysis of the sampled materials; library storage components, e.g., planar solid substrates, capable of retaining thousands, tens of thousands and hundreds of thousands of different materials in small areas; sensing systems for allowing rapid and accurate sampling of the materials by the microfluidic devices, and associated instrumentation for control and analysis of the overall operation of these systems.
    Type: Application
    Filed: May 29, 2003
    Publication date: January 22, 2004
    Applicant: Caliper Technologies Corp.
    Inventors: Jeffrey A. Wolk, Sherri Ann Biondi, J. Wallace Parce, Morten J. Jensen, Anne R. Kopf-Sill
  • Microfluidic device for sequencing by hybridization
    Patent number: 6670133
    Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: December 30, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
  • Sequencing by incorporation
    Publication number: 20030215862
    Abstract: Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by incorporation of the fluorescently labeled nucleotide, optionally followed by photobleaching and intercalating dyes are used to detect addition of a non-labeled nucleotide in sequencing by synthesis with detection by intercalation. Microfluidic devices, including particle arrays, are used in the sequencing methods.
    Type: Application
    Filed: April 14, 2003
    Publication date: November 20, 2003
    Applicant: Caliper Technologies Corp.
    Inventors: J. Wallace Parce, Theo T. Nikiforov, Tammy Burd Mehta, Anne R. Kopf-Sill, Andrea W. Chow, Michael R. Knapp
  • Modified siphons for improving metering precision
    Publication number: 20030207457
    Abstract: The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors comprise siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.
    Type: Application
    Filed: April 12, 2001
    Publication date: November 6, 2003
    Inventors: Anne R. Kopf-Sill, Carol T. Schembri
  • Manipulation of microparticles in microfluidic systems
    Patent number: 6632655
    Abstract: Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: October 14, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: Tammy Burd Mehta, Anne R. Kopf-Sill, J. Wallace Parce, Andrea W. Chow, Luc J. Bousse, Michael R. Knapp, Theo T. Nikiforov, Steve Gallagher
  • High throughput screening assay systems in microscale fluidic devices
    Patent number: 6630353
    Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: October 7, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: J. Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
  • Microfluidic viscometer
    Publication number: 20030182991
    Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
    Type: Application
    Filed: October 9, 2001
    Publication date: October 2, 2003
    Applicant: Caliper Technologies Corp.
    Inventors: Michael A. Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill
  • Ultra high throughput sampling and analysis systems and methods
    Patent number: 6620625
    Abstract: Ultra-high throughput systems and methods are used for sampling large numbers of different materials from surfaces of substantially planar library storage components. The systems and methods typically employ: microfluidic devices having integrated capillary elements for carrying out the analysis of the sampled materials; library storage components, e.g., planar solid substrates, capable of retaining thousands, tens of thousands and hundreds of thousands of different materials in small areas; sensing systems for allowing rapid and accurate sampling of the materials by the microfluidic devices, and associated instrumentation for control and analysis of the overall operation of these systems.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: September 16, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: Jeffrey A. Wolk, Sherri Ann Biondi, J. Wallace Parce, Morten J. Jensen, Anne R. Kopf-Sill
  • Systems for monitoring and controlling fluid flow rates in microfluidic systems
    Patent number: 6616823
    Abstract: The present invention generally provides methods and systems for monitoring and controlling electroosmotic flow rates in microfluidic systems. Generally, such methods and systems monitor flow rates in electroosmotically driven microfluidic systems by flowing signaling elements within these channels and measuring the flow rate of these signals. The methods of monitoring flow rates are also applied to methods and systems for continuously monitoring and controlling these flow rates in electroosmotically driven microfluidic systems.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: September 9, 2003
    Assignee: Caliper Technologies Corp.
    Inventor: Anne R. Kopf-Sill
  • Apparatus and methods for correcting for variable velocity in microfluidic systems
    Publication number: 20030165960
    Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.
    Type: Application
    Filed: February 5, 2003
    Publication date: September 4, 2003
    Applicant: Caliper Technologies Corp.
    Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Claudia B. Cohen, Steven A. Sundberg, John Wallace Parce
  • Sequencing by incorporation
    Patent number: 6613513
    Abstract: Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by incorporation of the fluorescently labeled nucleotide, optionally followed by photobleaching and intercalating dyes are used to detect addition of a non-labeled nucleotide in sequencing by synthesis with detection by intercalation. Microfluidic devices, including particle arrays, are used in the sequencing methods.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: September 2, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: J. Wallace Parce, Theo T. Nikiforov, Tammy Burd Mehta, Anne R. Kopf-Sill, Andrea W. Chow, Michael R. Knapp
  • Microfluidic systems and methods for determining modulator kinetics
    Patent number: 6613580
    Abstract: Methods, systems, kits, and apparatus for calculating kinetic and concentration information in microscale systems are provided. Dwell times for access by a microfluidic system are varied and the resulting modulation of signal profile information used to provide a first order estimation of an activity of a potential activity modulator accessed by the system.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: September 2, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: Andrea W. Chow, Anne R. Kopf-Sill, J. Wallace Parce
  • Apparatus and method for correcting for variable velocity in microfluidic systems
    Patent number: 6613512
    Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: September 2, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Claudia B. Jaffe, Steven A. Sunberg, John Wallace Parce
  • Closed-loop biochemical analyzers
    Publication number: 20030148922
    Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.
    Type: Application
    Filed: July 17, 2002
    Publication date: August 7, 2003
    Applicant: Caliper Technologies Corp.
    Inventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
  • Microfluidic devices, systems and methods for performing integrated reactions and separations
    Publication number: 20030138359
    Abstract: Microfluidic devices for performing integrated reaction and separation operations. The devices comprise a planar substrate having a first surface with an integrated channel network disposed therein. The reaction region in the integrated microscale channel network has a mixture of at least first and second reactants located therein, wherein the mixture interacts to produce one or more products. The reaction region is configured to maintain contact between the first and second reactants contained within it. The device also includes a separation region in the integrated channel network, where the separation region is configured to separate the first reactant from the product, when the first reactant and product are flowing through the separation region.
    Type: Application
    Filed: February 6, 2003
    Publication date: July 24, 2003
    Applicant: Caliper Technologies Corp.
    Inventors: Andrea W. Chow, Anne R. Kopf-Sill, J. Wallace Parce, Steven A. Sundberg
  • High throughput screening assay systems in microscale fluidic devices
    Publication number: 20030134431
    Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
    Type: Application
    Filed: October 24, 2002
    Publication date: July 17, 2003
    Applicant: Caliper Technologies Corp.
    Inventors: J. Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
  • Focusing of microparticles in microfluidic systems
    Patent number: 6592821
    Abstract: Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: July 15, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: H. Garrett Wada, Anne R. Kopf-Sill, Marja Liisa Alajoki, J. Wallace Parce, Benjamin N. Wang, Andrea W. Chow, Robert S. Dubrow, Yevgeny Yurkovetsky, Javier Anibal Farinas