Patents by Inventor Annekatrin Charlotte HEIMANN

Annekatrin Charlotte HEIMANN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 1,2,4-oxadiazoles as TRPA1 inhibitors
    Patent number: 11878981
    Abstract: The present disclosure provides certain substituted 1,2,4-oxadiazole derivatives of the below formula (I) that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: January 23, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Florian Paul Christian Binder, Georg Dahmann, Martin Thomas Fleck, Annekatrin Charlotte Heimann, Thorsten Oost
  • Thienopyrimidones
    Patent number: 11578080
    Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: February 14, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Thomas Fleck, Florian Paul Christian Binder, Georg Dahmann, Joerg P. Hehn, Annekatrin Charlotte Heimann, Uta Friederike Lessel, Jens Willwacher
  • PYRIDINE DERIVATIVES WITH C-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS
    Publication number: 20230002401
    Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compounds for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
    Type: Application
    Filed: May 10, 2022
    Publication date: January 5, 2023
    Inventors: Annekatrin Charlotte HEIMANN, Sandra Ruth HANDSCHUH, Christoph HOENKE, Christian GNAMM, Cédrickx GODBOUT, Patrick GROSS, Joerg KLEY, Christian Andreas KUTTRUFF, Dirk REINERT, Raphael STUBER
  • PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS
    Publication number: 20230000878
    Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compounds for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
    Type: Application
    Filed: May 10, 2022
    Publication date: January 5, 2023
    Inventors: Annekatrin Charlotte HEIMANN, Sandra Ruth HANDSCHUH, Christoph HOENKE, Cédrickx GODBOUT, Christian GNAMM, Patrick GROSS, Joerg KLEY, Christian Andreas KUTTRUFF, Dirk REINERT, Raphael STUBER
  • IMIDAZO[4,5-D]PYRIDAZINONYL DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220340580
    Abstract: The present disclosure provides certain imidazo[4,5-d]pyridazinonyl derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 27, 2022
    Inventors: Florian Paul Christian BINDER, Georg DAHMANN, Martin Thomas FLECK, Annekatrin Charlotte HEIMANN, Thorsten OOST
  • Novel Thienopyrimidones
    Publication number: 20210395267
    Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Application
    Filed: September 1, 2021
    Publication date: December 23, 2021
    Inventors: Martin Thomas FLECK, Florian Paul Christian BINDER, Georg DAHMANN, Joerg P. HEHN, Annekatrin Charlotte HEIMANN, Uta Friederike LESSEL, Jens WILLWACHER
  • Thienopyrimidones
    Patent number: 11136336
    Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: October 5, 2021
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Thomas Fleck, Florian Paul Christian Binder, Georg Dahmann, Joerg P. Hehn, Annekatrin Charlotte Heimann, Jens Willwacher
  • Novel Thienopyrimidones
    Publication number: 20210107919
    Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 15, 2021
    Inventors: Martin Thomas FLECK, Florian Paul Christian BINDER, Georg DAHMANN, Joerg P. HEHN, Annekatrin Charlotte HEIMANN, Uta Friederike LESSEL
  • Novel Thienopyrimidones
    Publication number: 20210107918
    Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 15, 2021
    Inventors: Martin Thomas FLECK, Florian Paul Christian BINDER, Georg DAHMANN, Joerg P. HEHN, Annekatrin Charlotte HEIMANN, Jens WILLWACHER
  • CYCLIC DINUCLEOTIDE COMPOUNDS CONTAINING 2-AZA-HYPOXANTHINE OR 6H-PYTAZOLO[1,5-D][1,2,4]TRIZAIN-7-ONE AS STRING AGONISTS
    Publication number: 20210009627
    Abstract: Compounds of formula I, wherein Base, R1 and R2 are defined as in claim 1, are modulators of STING.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 14, 2021
    Inventors: Annekatrin Charlotte HEIMANN, Martin FLECK, Christian Andreas KUTTRUFF, Thorsten OOST