Patents by Inventor Anthony Christodoulou
Anthony Christodoulou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11935158Abstract: A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.Type: GrantFiled: May 4, 2021Date of Patent: March 19, 2024Assignee: Cedars-Sinai Medical CenterInventors: Anthony Christodoulou, Zhaoyang Fan, Debiao Li, Pei Han
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Patent number: 11828825Abstract: A magnetic resonance imaging method is includes collecting spatially encoded data from a subject using an MRI system, and directly extracting a number of temporal basis functions using at least a first portion of the spatially encoded data. The method further includes, after directly extracting the number of temporal basis functions, iteratively calculating a number of coefficient images using the number of temporal basis functions and at least a second portion of the spatially encoded data. Finally, the method includes generating a 4D image based on the number of temporal basis functions and the number of coefficient images.Type: GrantFiled: April 30, 2021Date of Patent: November 28, 2023Assignees: University of Pittsburgh—Of the Commowealth System of Higher Education, Cedars-Sinai Medical CenterInventors: Yijen Lin Wu, Anthony Christodoulou
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Patent number: 11796616Abstract: A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.Type: GrantFiled: May 28, 2021Date of Patent: October 24, 2023Assignee: CEDARS-SINAI MEDICAL CENTERInventors: Debiao Li, Anthony Christodoulou, Zhaoyang Fan, Zixin Deng, Nan Wang, Zhengwei Zhou, Sen Ma, Christopher Nguyen, Yibin Xie, Jaime Shaw
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Publication number: 20230225628Abstract: A method for performing magnetic resonance imaging on a subject comprises: injecting a contrast agent into a region of interest of the subject; applying a pulse sequence to the region of interest; collecting auxiliary data for the region of interest, the auxiliary data being related to one or more time-varying parameters of the subject within the region of interest; determining a temporal factor ? from the auxiliary data; collecting imaging data for the region of interest, the imaging data being related to one or more spatially-varying parameters of the subject within the region of interest; determining a spatial factor Ur from the imaging data; modeling a multi-dimensional image sequence as I=Ur?; and deriving at least a first metric and a second metric from the multi-dimensional image sequence I, the first metric and the second metric being associated with distinct perfusion-based imaging techniques.Type: ApplicationFiled: June 16, 2021Publication date: July 20, 2023Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Zhaoyang Fan, Anthony Christodoulou, Debiao Li, Zhehao Hu
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Publication number: 20230222708Abstract: A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.Type: ApplicationFiled: May 4, 2021Publication date: July 13, 2023Inventors: Anthony Christodoulou, Zhaoyang Fan, Debiao Li, Pei Han
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SYSTEMS AND METHODS OF DEEP LEARNING FOR LARGE-SCALE DYNAMIC MAGNETIC RESONANCE IMAGE RECONSTRUCTION
Publication number: 20230194640Abstract: A method for performing magnetic resonance imaging on a subject comprises obtaining undersampled imaging data, extracting one or more temporal basis functions from the imaging data, extracting one or more preliminary spatial weighting functions from the imaging data, inputting the one or more preliminary spatial weighting functions into a neural network to produce one or more final spatial weighting functions, and multiplying the one or more final spatial weighting functions by the one or more temporal basis functions to generate an image sequence. Each of the temporal basis functions corresponds to at least one time-varying dimension of the subject. Each of the preliminary spatial weighting functions corresponds to a spatially-varying dimension of the subject. Each of the final spatial weighting functions is an artifact-free estimation of the one of the one or more preliminary spatial weighting functions.Type: ApplicationFiled: September 10, 2020Publication date: June 22, 2023Inventors: Anthony CHRISTODOULOU, Debiao LI, Yuhua CHEN -
Publication number: 20220099775Abstract: A method of analyzing a multidimensional image tensor containing a plurality of images comprises: performing imaging scans of a subject imaging data; generating the multidimensional image tensor from the imaging data; determining a spatial basis tensor containing basis images based on the multidimensional image tensor; determining a temporal basis tensor containing basis functions for a temporal dimension based on the multidimensional image tensor; determining a core tensor that relates the spatial basis tensor to the temporal basis tensor; pre-multiplying the core tensor and the temporal basis tensor to produce a modified temporal basis tensor; storing the spatial basis tensor and the modified temporal basis tensor; and generating an image by multiplying at least (i) at least a portion of the spatial basis tensor and (ii) at least a portion of the modified temporal basis tensor.Type: ApplicationFiled: September 18, 2019Publication date: March 31, 2022Inventors: Debiao LI, Anthony CHRISTODOULOU, Yibin XIE
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Publication number: 20210356544Abstract: A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.Type: ApplicationFiled: May 28, 2021Publication date: November 18, 2021Inventors: Debiao Li, Anthony Christodoulou, Zhaoyang Fan, Zixin Deng, Nan Wang, Zhengwei Zhou, Sen Ma, Christopher Nguyen, Yibin Xie, Jaime Shaw
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Publication number: 20210349167Abstract: A magnetic resonance imaging method is includes collecting spatially encoded data from a subject using an MRI system, and directly extracting a number of temporal basis functions using at least a first portion of the spatially encoded data. The method further includes, after directly extracting the number of temporal basis functions, iteratively calculating a number of coefficient images using the number of temporal basis functions and at least a second portion of the spatially encoded data. Finally, the method includes generating a 4D image based on the number of temporal basis functions and the number of coefficient images.Type: ApplicationFiled: April 30, 2021Publication date: November 11, 2021Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, CEDARS-SINAI MEDICAL CENTERInventors: YIJEN LIN WU, ANTHONY CHRISTODOULOU
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Patent number: 11022666Abstract: A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.Type: GrantFiled: May 8, 2019Date of Patent: June 1, 2021Assignee: Cedars-Sinai Medical CenterInventors: Debiao Li, Anthony Christodoulou, Zhaoyang Fan, Zixin Deng, Nan Wang, Zhengwei Zhou, Sen Ma, Christopher Nguyen, Yibin Xie, Jaime Shaw
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Publication number: 20190346523Abstract: A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.Type: ApplicationFiled: May 8, 2019Publication date: November 14, 2019Applicant: Cedars-Sinai Medical CenterInventors: Debiao Li, Anthony Christodoulou, Zhaoyang Fan, Zixin Deng, Nan Wang, Zhengwei Zhou, Sen Ma, Christopher Nguyen, Yibin Xie, Jaime Shaw