Patents by Inventor Anthony D'Onofrio

Anthony D'Onofrio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240082282
    Abstract: This disclosure provides compounds and compositions useful for treating spirochete diseases such as Lyme disease as well as baits containing the compounds.
    Type: Application
    Filed: September 1, 2021
    Publication date: March 14, 2024
    Inventors: Anthony D'ONOFRIO, Kim LEWIS
  • Publication number: 20230042960
    Abstract: Disclosed herein are compositions and methods for the treatment and/or detection of diseases such as, but not limited to Lyme disease, Lyme disease-related disorders including post-treatment Lyme disease syndrome (PTLDS), chronic Lyme disease (CLD) and/or inflammation.
    Type: Application
    Filed: December 10, 2020
    Publication date: February 9, 2023
    Applicant: Northeastern University
    Inventors: Kim LEWIS, Madeleine MORRISSETTE, Philip STRANDWITZ, Anthony D'ONOFRIO, Norman PITT
  • Publication number: 20210301316
    Abstract: Assays for compounds having a desired biological activity against one but not both of a pair of microorganism species utilize separately detectable labels. The first and second microorganisms are different from each other, the first microorganisms exhibit a first detectable label, the second microorganisms exhibit a second detectable label different from the first detectable label, and neither of the labels interferes with detection of the other label. In various embodiments, the first and second microorganisms are incubated with a candidate compound or a producer thereof The different labels permit isolation of microorganisms exhibiting one of the labels but not the other, indicating the desired activity, and the compound responsible for this differential response is isolated.
    Type: Application
    Filed: May 24, 2019
    Publication date: September 30, 2021
    Inventors: Kim LEWIS, Anthony D'ONOFRIO, Thomas CURTIS, Charlotte BERKES
  • Publication number: 20210275559
    Abstract: This invention provides, among other things, compounds useful for treating spirochete diseases such as Lyme disease, as well as pharmaceutical formulations and/or environmental baits containing such compounds.
    Type: Application
    Filed: August 19, 2019
    Publication date: September 9, 2021
    Inventors: Kim LEWIS, Yu IMAI, Xiaoqian (Wendy) WU, Anthony D'ONOFRIO
  • Publication number: 20140199372
    Abstract: Disclosed are methods of cultivating or isolating a microorganism using one or more quinones as growth factors. Also disclosed are methods of treating a mammalian species with deficiency in symbionts using such compounds.
    Type: Application
    Filed: May 24, 2012
    Publication date: July 17, 2014
    Applicant: NORTHEASTERN UNIVERSITY
    Inventors: Kim Lewis, Pallavi Murugkar, Anthony D'onofrio, Eric Stewart, Eric Dimise, Jon Clardy, Kathrin Witt, Bijaya Sharma
  • Patent number: 4812945
    Abstract: A method for providing a power management for a DC solenoid actuator includes the steps of initially supplying a first number of DC current pulses to the actuator and after a first time interval reducing the number of pulses applied to the solenoid in direct proportion to an output voltage of a source of the DC power. The method further includes the step of changing the duration of the first time period in direct proportion to the output voltage of the source of the DC power.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: March 14, 1989
    Assignee: Honeywell Inc.
    Inventor: Anthony D'Onofrio
  • Patent number: 4737882
    Abstract: A proportional solenoid valve control circuit uses a solenoid current driver, a feedback circuit for providing a feedback signal representative of an output current supplied by the drive means, input signal means for connection to a source of a control signal representative of a desired current to be supplied by the driver means, signal comparison means for comparing the feedback signal with the control signal to produce an error signal representing the difference therebetween, timer means connected to the comparison means for producing an output signal having a frequency dependent on the magnitude of the error signal and a circuit for applying the output signal to the current driver to produce the output current from the driver proportional to the output signal.
    Type: Grant
    Filed: February 9, 1987
    Date of Patent: April 12, 1988
    Assignee: Honeywell Inc.
    Inventor: Anthony D'Onofrio
  • Patent number: 4630165
    Abstract: A D.C. power control for a D.C. solenoid actuator which may be used for a D.C. solenoid operated valve uses a timer circuit for switching from an initial high pull-in power after a predetermined delay to a low hold power for the valve solenoid utilizing a pulse control where the valve "on" time is held constant and the "off" time is varied. The pulses are high frequency to prevent the valve from switching with each of the pulses while enabling the average current in the valve solenoid coil to be controlled independently between the pull-in and hold current values.
    Type: Grant
    Filed: October 10, 1985
    Date of Patent: December 16, 1986
    Assignee: Honeywell Inc.
    Inventor: Anthony D'Onofrio
  • Patent number: 4630166
    Abstract: An A.C. power control circuit for a D.C. solenoid actuator which may be used for a solenoid operated valve uses a triac circuit to initially apply A.C. line voltage to energize the solenoid coil of the valve to be actuated to provide valve pull-in power. A capacitor in an RC network is concurrently charged to a D.C. level, and the D.C. voltage on the capacitor is used to control the gate of the triac. After a predetermined delay as determined by the RC network charging time of the capacitor, the triac is phase controlled to produce a change in the current applied to the solenoid coil. In one embodiment, the voltage applied to the solenoid coil changes at this time from the full sine wave voltage of the A.C. source to a voltage pulse which is only a portion of the positive half of the input sine wave. This voltage produces a change in the power applied to the solenoid coil to a hold-in power level. This circuit produces a current pulse phase control of up to 90.degree..
    Type: Grant
    Filed: October 17, 1985
    Date of Patent: December 16, 1986
    Assignee: Honeywell Inc.
    Inventor: Anthony D'Onofrio
  • Patent number: 4534743
    Abstract: A process for making thin flexible electroluminescent lamps comprises continuously feeding a flexible strip of transparent insulating material which serves as the carrier for performing various process steps, as well as becoming part of the finished lamp itself. The strip is provided with a thin transparent conductive layer. An epoxy/phosphor mixture is continuously applied to a controlled thickness over the conductive layer and cured in an oven. Another conductive layer is continuously applied over the cured epoxy/phosphor layer on the carrier sheet and dried. In a preferred embodiment, lamp members are severed from the roll, and a narrow groove is made in the last applied conductive layer to divide the conductive layer into two exposed electrode areas to which the lamp terminals are connected. In another embodiment, the conductive layer on the plastic carrier sheet is continuously subdivided by vaporizing the conductive material to form a narrow groove with an electric arc.
    Type: Grant
    Filed: August 31, 1983
    Date of Patent: August 13, 1985
    Assignee: Timex Corporation
    Inventors: Anthony D'Onofrio, Walter Kitik
  • Patent number: 4449075
    Abstract: An electroluminescent lamp driver circuit is disclosed, which includes a timer circuit acting as a retriggerable astable multivibrator interfacing with transistor-transistor logic (TTL) circuitry. The timer circuit sets the operating frequency of the entire lamp driver circuit while the TTL circuitry includes a transistor for controlling the operating voltage of the TTL circuit and two additional transistors for providing the switching for periodically exciting the phosphor in the lamp to luminesce.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: May 15, 1984
    Assignee: Timex Corporation
    Inventors: Anthony D'Onofrio, Jack Gunzy
  • Patent number: D263811
    Type: Grant
    Filed: April 7, 1980
    Date of Patent: April 13, 1982
    Assignee: Timex Corporation
    Inventors: Paul Hochstrate, Anthony D'Onofrio