Patents by Inventor Anthony Ratcliffe

Anthony Ratcliffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7935363
    Abstract: The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: May 3, 2011
    Assignee: Synthasome, Inc.
    Inventor: Anthony Ratcliffe
  • Publication number: 20110082389
    Abstract: A measuring system may provide quantitative information relating to condition of cartilage. Negative pressure may be applied to cartilage to induce flow of fluid from or through the cartilage. A level of negative pressure needed to induce a particular flow of the fluid may be employed to provide a quantitative indicia of cartilage condition. An averaged level of negative pressure measured over a period of time may be used to calculate hydraulic resistance of the cartilage.
    Type: Application
    Filed: October 6, 2010
    Publication date: April 7, 2011
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SYNTHASOME, INC.
    Inventors: WILLIAM JOSEPH McCARTY, PRIYA SUNDARAMURTHY, CARYN URBANCZYK, ATAL PATEL, JACOB HAHR, ROBERT L. SAH, MOHAMMAD SOTOUDEH, ANTHONY RATCLIFFE
  • Patent number: 7897165
    Abstract: The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells. The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM. Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: March 1, 2011
    Assignee: Synthasome, Inc.
    Inventors: Jennifer Elisseeff, Dong-an Wang, Anthony Ratcliffe
  • Publication number: 20110033434
    Abstract: The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
    Type: Application
    Filed: September 2, 2010
    Publication date: February 10, 2011
    Applicant: Theregen, Inc.
    Inventors: Anthony Ratcliffe, Jonathan Noel Mansbridge, Lee K. Landeen, Emmett Pinney, Linette J. Edison
  • Publication number: 20110029078
    Abstract: Synthetic structures for soft tissue repair include a multi-layer planar fibrillar structure having layers which are intermittently secured to each other and which approximates mechanical properties comparable to those of soft tissue. In embodiments, the fibrillar structure possesses an intermittently secured edge portion secured by intermittent welds. In embodiments, the multi layer planar fibrillar structure includes a bioactive agent.
    Type: Application
    Filed: July 31, 2009
    Publication date: February 3, 2011
    Inventors: Anthony Ratcliffe, Andreas Kern, Mohammad Sotoudeh, Fatemeh Ratcliffe
  • Patent number: 7862831
    Abstract: The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells. The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM. Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: January 4, 2011
    Assignee: Synthasome, Inc.
    Inventors: Dongan Wang, Anthony Ratcliffe, Jennifer H. Elisseeff
  • Publication number: 20100145367
    Abstract: Synthetic structures for fibrous soft tissue repair include a planar fibrillar structure which exhibits mechanical properties comparable to those of human fibrous soft tissue. In embodiments, the fibrillar structure possesses at least one secured folded edge portion.
    Type: Application
    Filed: February 13, 2008
    Publication date: June 10, 2010
    Inventor: Anthony Ratcliffe
  • Publication number: 20090123435
    Abstract: The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
    Type: Application
    Filed: September 26, 2008
    Publication date: May 14, 2009
    Applicant: Theregen, Inc.
    Inventors: Anthony Ratcliffe, Jonathan Noel Mansbridge, Lee K. Landeen, Emmett Pinney, Linette J. Edison
  • Publication number: 20090123503
    Abstract: Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder.
    Type: Application
    Filed: January 6, 2009
    Publication date: May 14, 2009
    Applicant: SkinMedica. Inc.
    Inventors: Gail K. Naughton, David L. Horwitz, Mark A. Applegate, Joan Zeltinger, Jonathan N. Mansbridge, Andreas Kern, Lee K. Landeen, Anthony Ratcliffe, R. Emmett Pinney
  • Publication number: 20080139694
    Abstract: The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.
    Type: Application
    Filed: December 12, 2006
    Publication date: June 12, 2008
    Inventor: Anthony Ratcliffe
  • Publication number: 20080051888
    Abstract: Synthetic structures for fibrous soft tissue repair include a polymeric fibrillar structure that exhibits mechanical properties of the human fibrous soft tissue.
    Type: Application
    Filed: August 17, 2007
    Publication date: February 28, 2008
    Inventors: Anthony Ratcliffe, Andreas Kern
  • Publication number: 20070276509
    Abstract: A tissue engineered construct made totally or in part from biocompatible materials and mammalian cells and/or cell products is provided. These constructs are useful in regenerating complex tissues such as bone, ligament and tendon, which may fabricated into medical devices suitable for use in the treatment of injuries and maladies such as rotator cuff injuries, periodontal disease and hernia.
    Type: Application
    Filed: August 9, 2007
    Publication date: November 29, 2007
    Inventors: Anthony Ratcliffe, Andreas Kern, Fatemeh Ratcliffe
  • Publication number: 20070077232
    Abstract: Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder.
    Type: Application
    Filed: October 3, 2006
    Publication date: April 5, 2007
    Applicant: SkinMedica, Inc.
    Inventors: Gail Naughton, David Horwitz, Mark Applegate, Joan Zeltinger, Jonathan Mansbridge, Andreas Kern, Lee Landeen, Anthony Ratcliffe, R. Pinney
  • Publication number: 20070048291
    Abstract: The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells. The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM. Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.
    Type: Application
    Filed: March 7, 2006
    Publication date: March 1, 2007
    Inventors: Pongan Mang, Anthony Ratcliffe, Jennifer Elisseeff
  • Patent number: 7118746
    Abstract: Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: October 10, 2006
    Assignee: SkinMedica, Inc.
    Inventors: Gail K. Naughton, David L. Horwitz, Mark A. Applegate, Joan Zeltinger, Jonathan N. Mansbridge, Andreas Kern, Lee K. Landeen, Anthony Ratcliffe, R. Emmett Pinney
  • Publication number: 20060154365
    Abstract: The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
    Type: Application
    Filed: August 30, 2005
    Publication date: July 13, 2006
    Inventors: Anthony Ratcliffe, Jonathan Mansbridge, Lee Landeen, Emmett Pinney, Linette Edison
  • Publication number: 20050196377
    Abstract: The present invention provides a composition and method for the covalent binding of a hydrogel to an extracellular matrix (ECM). Therapeutic applications include tissue repair and delivery of drugs or cells.
    Type: Application
    Filed: October 9, 2004
    Publication date: September 8, 2005
    Inventors: Anthony Ratcliffe, Jennifer Elisseeff, Dongan Wang
  • Publication number: 20050101169
    Abstract: A connector is described wherein the connector comprises a socket for receiving a plug having a plurality of pins wherein the socket presents a greater resistance to withdrawal of at least one pin than insertion of the pin. Preferably, removal of the pin is substantially prevented except by means of a release mechanism which may optionally be provided.
    Type: Application
    Filed: December 17, 2002
    Publication date: May 12, 2005
    Inventor: Anthony Ratcliffe
  • Publication number: 20040170663
    Abstract: The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells.
    Type: Application
    Filed: October 9, 2003
    Publication date: September 2, 2004
    Applicant: Jennifer H. Elisseeff
    Inventors: Dongan Wang, Anthony Ratcliffe, Jennifer H. Elisseeff
  • Patent number: 5916557
    Abstract: The present invention relates to the use of an ECM-altering enzymatic activity, such as a proteoglycanase or a protease, to stimulate the generation of cartilage tissue by inducing chondrocytes to synthesize new cartilage matrix. It has been discovered that treating chondrocytes with an enzymatic activity that modifies the territorial ECM of the cell, especially cell surface proteoglycans, can in and of itself be sufficient to stimulate cartilage production by the chondrocytes. The subject invention can be employed therapeutically to correct or prevent degeneration of connective tissue. For instance, the present method can be used in the treatment of disorders comprising cartilage such as found in an diarthroidal joint (e.g. articular and interarticular cartilage), as well as in the treatment of tendon and ligamental tissues. Such disorders can range from chronic degeneration brought about by disease, overuse, or trauma, to plastic or reconstructive surgery.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: June 29, 1999
    Assignees: The Trustees of Columbia University in the City of New York, International Technology Management Associates, Ltd.
    Inventors: Laurence Berlowitz-Tarrant, Anthony Ratcliffe, Shuichi Mizuno