Patents by Inventor Anthony W. S. Chan

Anthony W. S. Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240301349
    Abstract: Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.
    Type: Application
    Filed: February 13, 2024
    Publication date: September 12, 2024
    Inventors: Charles A. Easley, IV, Anthony W.S. Chan
  • Patent number: 11939593
    Abstract: Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: March 26, 2024
    Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., EMORY UNIVERSITY
    Inventors: Charles A. Easley, IV, Anthony W. S. Chan
  • Publication number: 20210340493
    Abstract: Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.
    Type: Application
    Filed: August 1, 2019
    Publication date: November 4, 2021
    Inventors: Charles A. Easley,, IV, Anthony W.S. Chan
  • Patent number: 7138562
    Abstract: The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: November 21, 2006
    Assignee: Wisconsin Alumni research Foundation
    Inventors: Robert D. Bremel, Anthony W. S. Chan, Jane C. Burns
  • Publication number: 20030221206
    Abstract: The present invention relates to methods for producing transgenic animals. Specifically, the methods of the present invention include production of a transgenic animal by transgenic intracytoplasmic sperm injection, retroviral gene transfer, intracytoplasmic nuclear injection, and pronuclear injection. In addition, the present invention also relates to methods for using transgenic animals as models for human disease and diagnosis. In particular, these transgenic animals may be used as models for embryo and fetal development, as models to assess the safety and efficacy of drug therapy and gene therapy, and as models for disease diagnosis. The methods of the present invention are also directed to methods of using transgenic embryonic cells to treat human diseases.
    Type: Application
    Filed: April 21, 2003
    Publication date: November 27, 2003
    Applicant: Oregon Health & Science University
    Inventors: Gerald Schatten, Anthony W.S. Chan
  • Publication number: 20030106082
    Abstract: The present invention relates to the clonal propagation of primate offspring by embryo splitting. Here, genetically identical nonhuman embryos may be produced as twin and larger sets by separation and reaggregation of blastomeres of cleavage-stage embryos. Furthermore, the present invention also relates to methods for producing embryonic stem cells and transgenic embryonic stem cells isolated from dissociated blastomeres.
    Type: Application
    Filed: January 9, 2003
    Publication date: June 5, 2003
    Applicant: Oregon Health & Science University
    Inventors: Gerald Schatten, Anthony W.S. Chan
  • Patent number: 6548740
    Abstract: The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: April 15, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert D. Bremel, Anthony W.S. Chan, Jane C. Burns
  • Publication number: 20020129393
    Abstract: The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
    Type: Application
    Filed: July 18, 2001
    Publication date: September 12, 2002
    Inventors: Robert D. Bremel, Anthony W.S. Chan, Jane C. Burns
  • Publication number: 20020035735
    Abstract: The present invention relates to the clonal propagation of primate offspring by embryo splitting. Here, genetically identical nonhuman embryos may be produced as twin and larger sets by separation and reaggregation of blastomeres of cleavage-stage embryos. Furthermore, the present invention also relates to methods for producing embryonic stem cells and transgenic embryonic stem cells isolated from dissociated blastomeres.
    Type: Application
    Filed: January 5, 2001
    Publication date: March 21, 2002
    Inventors: Gerald Schatten, Anthony W.S. Chan
  • Publication number: 20010044937
    Abstract: The present invention relates to methods for producing transgenic animals. Specifically, the methods of the present invention include production of a transgenic animal by transgenic intracytoplasmic sperm injection, retroviral gene transfer, intracytoplasmic nuclear injection, and pronuclear injection. In addition, the present invention also relates to methods for using transgenic animals as models for human disease and diagnosis. In particular, these transgenic animals may be used as models for embryo and fetal development, as models to assess the safety and efficacy of drug therapy and gene therapy, and as models for disease diagnosis. The methods of the present invention are also directed to methods of using transgenic embryonic cells to treat human diseases.
    Type: Application
    Filed: December 15, 2000
    Publication date: November 22, 2001
    Inventors: Gerald Schatten, Anthony W.S. Chan
  • Patent number: 6291740
    Abstract: The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: September 18, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert D. Bremel, Anthony W. S. Chan, Jane C. Burns
  • Patent number: 6080912
    Abstract: The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: June 27, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert D. Bremel, Anthony W. S. Chan, Jane C. Burns