Patents by Inventor Antje Bruckbauer

Antje Bruckbauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200338078
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions comprise a combination of a PDE 5 inhibitor, such as sildenafil or icariin, and resveratrol, and a branched amino acid such as leucine, or its metabolite.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 29, 2020
    Inventors: Michael Zemel, Antje Bruckbauer, Brooke Baggett
  • Patent number: 10646489
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions comprise a combination of a PDE 5 inhibitor, such as sildenafil or icariin, and resveratrol, and a branched amino acid such as leucine, or its metabolite.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: May 12, 2020
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, Antje Bruckbauer, Brooke Baggett
  • Patent number: 10383837
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: August 20, 2019
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
  • Publication number: 20190224152
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
    Type: Application
    Filed: August 14, 2018
    Publication date: July 25, 2019
    Inventors: Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
  • Patent number: 10344002
    Abstract: Methods and compounds useful for reducing, treating, preventing, or sustaining the reduction of a metabolic disease or disorder are provided herein. Also provided herein are compositions and kits for practicing any of the methods described herein.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: July 9, 2019
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, Antje Bruckbauer
  • Patent number: 10076507
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 18, 2018
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
  • Publication number: 20180235970
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions comprise a combination of a PDE 5 inhibitor, such as sildenafil or icariin, and resveratrol, and a branched amino acid such as leucine, or its metabolite.
    Type: Application
    Filed: February 7, 2018
    Publication date: August 23, 2018
    Inventors: Michael Zemel, Antje Bruckbauer, Brooke Baggett
  • Publication number: 20180235917
    Abstract: Compositions, methods and kits for treatment of diabetes and/or hyperlipidemia are provided herein. Such compositions can contain synergizing amounts of leucine and/or one or more leucine metabolites in combination with nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites, and with at least one or more anti-diabetic agents. Such compositions can contain sub-therapeutic amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites, and/or sub-therapeutic amounts of one or more anti-diabetic agents that can achieve the same therapeutic efficacy as therapeutic amounts of said compositions in diabetes and/or hyperlipidemia medicaments. The composition can also reduce the side effects associated with treatment using anti-diabetic agents and/or nicotinic acid.
    Type: Application
    Filed: September 23, 2015
    Publication date: August 23, 2018
    Applicant: NuSirt Sciences, Inc.
    Inventors: Michael ZEMEL, Antje BRUCKBAUER
  • Patent number: 10039733
    Abstract: Compositions, methods, and kits useful for treating pulmonary conditions are provided herein. Such compositions can contain synergizing amounts of a non-specific phosphodiesterase inhibitor, such as a methylxanthine, in combination with leucine and/or a leucine metabolite, and resveratrol.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: August 7, 2018
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, Brooke Baggett, Antje Bruckbauer
  • Publication number: 20180214421
    Abstract: Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites in combination with leucine and/or a leucine metabolite, with or without resveratrol.
    Type: Application
    Filed: December 21, 2017
    Publication date: August 2, 2018
    Inventors: Michael Zemel, Antje Bruckbauer
  • Publication number: 20180169043
    Abstract: Methods useful for reducing or preventing non-alcoholic steatohepatitis or hepatic steatosis are provided herein. Such methods may comprise administering to a subject in need thereof a sirtuin pathway activator and/or PDE5 inhibitor alone or in combination with an amount of a branched amino acid in free amino acid form, or a metabolite thereof. Also provided herein are compositions and kits for practicing any of the methods described herein.
    Type: Application
    Filed: December 15, 2017
    Publication date: June 21, 2018
    Inventors: Michael ZEMEL, Antje BRUCKBAUER
  • Publication number: 20180105498
    Abstract: Methods and compounds useful for reducing, treating, preventing, or sustaining the reduction of a metabolic disease or disorder are provided herein. Also provided herein are compositions and kits for practicing any of the methods described herein.
    Type: Application
    Filed: September 26, 2017
    Publication date: April 19, 2018
    Inventors: Michael Zemel, Antje Bruckbauer
  • Patent number: 9943517
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions comprise a combination of a PDE 5 inhibitor, such as sildenafil or icariin, and resveratrol, and a branched amino acid such as leucine, or its metabolite.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: April 17, 2018
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, Antje Bruckbauer, Brooke Baggett
  • Patent number: 9895357
    Abstract: Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites in combination with leucine and/or a leucine metabolite, with or without resveratrol.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: February 20, 2018
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, Antje Bruckbauer
  • Patent number: 9872844
    Abstract: Methods useful for reducing or preventing non-alcoholic steatohepatitis or hepatic steatosis are provided herein. Such methods may comprise administering to a subject in need thereof a sirtuin pathway activator and/or PDE5 inhibitor alone or in combination with an amount of a branched amino acid in free amino acid form, or a metabolite thereof. Also provided herein are compositions and kits for practicing any of the methods described herein.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: January 23, 2018
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, Antje Bruckbauer
  • Patent number: 9855235
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: January 2, 2018
    Assignee: NuSirt Sciences, Inc.
    Inventors: Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
  • Publication number: 20170368012
    Abstract: Compositions, methods, and kits useful for treating pulmonary conditions are provided herein. Such compositions can contain synergizing amounts of a non-specific phosphodiesterase inhibitor, such as a methylxanthine, in combination with leucine and/or a leucine metabolite, and resveratrol.
    Type: Application
    Filed: July 11, 2017
    Publication date: December 28, 2017
    Inventors: Michael Zemel, Brooke Baggett, Antje Bruckbauer
  • Publication number: 20170340615
    Abstract: Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites in combination with leucine and/or a leucine metabolite, with or without resveratrol.
    Type: Application
    Filed: June 9, 2017
    Publication date: November 30, 2017
    Inventors: Michael Zemel, Antje Bruckbauer
  • Publication number: 20170312240
    Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
    Type: Application
    Filed: May 15, 2017
    Publication date: November 2, 2017
    Inventors: Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
  • Publication number: 20170239253
    Abstract: Methods useful for sustaining a reduction of non-alcoholic steatohepatitis are provided herein. Such methods may comprise administering to a subject in need thereof a sirtuin pathway activator and/or PDE5 inhibitor alone or in combination with an amount of a branched amino acid in free amino acid form, or a metabolite thereof. Also provided herein are compositions and kits for practicing any of the methods described herein.
    Type: Application
    Filed: March 1, 2017
    Publication date: August 24, 2017
    Inventors: Michael Zemel, Antje Bruckbauer