Patents by Inventor Anton Wyss-Coray

Anton Wyss-Coray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200399644
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: April 7, 2020
    Publication date: December 24, 2020
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • Publication number: 20200352994
    Abstract: Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in need thereof, e.g., an individual suffering from or at risk of developing the aging-associated condition, e.g., aging-associated cognitive impairment. Also provided are compositions and kits thereof that find use in practicing methods of the invention.
    Type: Application
    Filed: May 21, 2020
    Publication date: November 12, 2020
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Joseph M. Castellano, Jinte Middeldorp, Martin S. Angst, Jian Luo
  • Publication number: 20200345812
    Abstract: The present invention provides methods for preventing, attenuating neuronal damage or stimulating neuronal repair prior or following central nervous system injury.
    Type: Application
    Filed: May 21, 2020
    Publication date: November 5, 2020
    Inventors: Jian Luo, Anton Wyss-Coray
  • Publication number: 20200317778
    Abstract: Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 8, 2020
    Inventors: Anton Wyss-Coray, John Vincent Pluvinage, Michael C. Bassik, Michael Haney, Benjamin Smith, Carolyn Bertozzi
  • Publication number: 20200254075
    Abstract: Methods of treating an adult mammal for an aging-associated condition are provided. Aspects of the methods include enhancing a TIMP activity, e.g., a TIMP2 activity, in the mammal in a manner sufficient to treat the adult mammal for the aging-associated condition. Also provided are compositions for use in practicing methods of the invention. A variety of aging-associated conditions may be treated by practice of the methods, which conditions include cognitive impairments.
    Type: Application
    Filed: April 7, 2020
    Publication date: August 13, 2020
    Inventors: Anton Wyss-Coray, Joseph M. Castellano
  • Patent number: 10688130
    Abstract: Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in need thereof, e.g., an individual suffering from or at risk of developing the aging-associated condition, e.g., aging-associated cognitive impairment. Also provided are compositions and kits thereof that find use in practicing methods of the invention.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: June 23, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Joseph M. Castellano, Jinte Middeldorp, Martin S. Angst, Jian Luo
  • Patent number: 10688154
    Abstract: The present invention provides methods for preventing, attenuating neuronal damage or stimulating neuronal repair prior or following central nervous system injury.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: June 23, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Jian Luo, Anton Wyss-Coray
  • Patent number: 10626399
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: April 21, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • Patent number: 10617744
    Abstract: Methods of treating an adult mammal for an aging-associated condition are provided. Aspects of the methods include enhancing a TIMP activity, e.g., a TIMP2 activity, in the mammal in a manner sufficient to treat the adult mammal for the aging-associated condition. Also provided are compositions for use in practicing methods of the invention. A variety of aging-associated conditions may be treated by practice of the methods, which conditions include cognitive impairments.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: April 14, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Joseph M. Castellano
  • Patent number: 10487148
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: November 26, 2019
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ALKAHEST, INC.
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Karoly Nikolich
  • Publication number: 20190185862
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: January 6, 2017
    Publication date: June 20, 2019
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • Publication number: 20190106495
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the ?2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: October 23, 2018
    Publication date: April 11, 2019
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Karoly Nikolich
  • Publication number: 20190024091
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: January 6, 2017
    Publication date: January 24, 2019
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • Publication number: 20180353578
    Abstract: Methods of treating an adult mammal for an aging-associated condition are provided. Aspects of the methods include enhancing a TIMP activity, e.g., a TIMP2 activity, in the mammal in a manner sufficient to treat the adult mammal for the aging-associated condition. Also provided are compositions for use in practicing methods of the invention. A variety of aging-associated conditions may be treated by practice of the methods, which conditions include cognitive impairments.
    Type: Application
    Filed: June 6, 2016
    Publication date: December 13, 2018
    Inventors: Anton Wyss-Coray, Joseph M. Castellano
  • Publication number: 20180298102
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: May 17, 2016
    Publication date: October 18, 2018
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Karoly Nikolich
  • Publication number: 20180099027
    Abstract: The present invention provides methods for preventing, attenuating neuronal damage or stimulating neuronal repair prior or following central nervous system injury.
    Type: Application
    Filed: August 25, 2017
    Publication date: April 12, 2018
    Inventors: Jian Luo, Anton Wyss-Coray
  • Patent number: 9809597
    Abstract: Compositions and methods for modulating innate and adaptive immunity and for use in immunotherapy are disclosed. In particular, the invention relates to novel ganciclovir derivatives and methods of using them for the treatment of immune-related disorders, including inflammation, autoimmunity, and infections, and neurological disorders, and cancer.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: November 7, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ritwik Burai, Hilal Lashuel, Vidhu Mathur, Anton Wyss-Coray
  • Patent number: 9796674
    Abstract: Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-B signaling are described. In particular, the compositions and methods are useful for reducing or eliminating the pathologies associated with Alzheimer's disease. The compositions include urea derivatives containing a piperidine, piperidinium, or a piperidin-4-yl methyl; cycloalkyl, aryl, and fluorobenzyl moieties.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 24, 2017
    Inventors: Mary Jean Tanga, Laura Ellen Downs Beaulieu, Anton Wyss-Coray, Carol Green, Hui Zhang, Jian Luo
  • Patent number: 9770486
    Abstract: Disclosed are novel methods for preventing or attenuating neuronal damage or stimulating neuronal repair, prior to or following central nervous system injury associated with acute or chronic nervous system injury. Macrophage colony stimulating factor receptor agonists including macrophage colony stimulating factor (M-CSF or CSF-1), interleukin-34 (IL-34), proteins or biologically active fragments thereof, peptides or biologically active fragments thereof, peptidomimetics, or small molecules, and the like are effective for prevention or treatment of acute nervous system injury or chronic nervous system injury involving Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and the like.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: September 26, 2017
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Jian Luo, Anton Wyss-Coray
  • Publication number: 20170232118
    Abstract: Methods and compositions are provided for screening candidate compositions for activity with respect to treatment of aging-associated conditions, e.g., cognitive impairment conditions or age-related dementia. Aspects of the methods include administering a human blood product comprising plasma, to an immunocompromised animal, e.g., a mouse or a rat, and measuring the effect of the product on an endpoint, e.g., neurogenesis, locomotor activity, anxiety, spatial memory, and hippocampus-dependent memory.
    Type: Application
    Filed: May 2, 2017
    Publication date: August 17, 2017
    Inventors: Steven Braithwaite, Saul A. Villeda, Anton Wyss-Coray