Patents by Inventor Antoni Kozlowski

Antoni Kozlowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200009260
    Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Application
    Filed: September 20, 2019
    Publication date: January 9, 2020
    Inventor: Antoni Kozlowski
  • Publication number: 20190375892
    Abstract: Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
    Type: Application
    Filed: August 21, 2019
    Publication date: December 12, 2019
    Inventors: Antoni Kozlowski, Jon McKannan, Samuel P. McManus
  • Patent number: 10456476
    Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 29, 2019
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Patent number: 10421838
    Abstract: Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: September 24, 2019
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Jon McKannan, Samuel P. McManus
  • Publication number: 20190142798
    Abstract: The invention relates to (among other things) polymer-des-ethyl sunitinib conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over des-ethyl sunitinib in unconjugated form.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 16, 2019
    Inventors: Antoni Kozlowski, Sean M. Culbertson, Xiaoming Shen, Samuel P. McManus, Mark A. Wilson
  • Publication number: 20190071454
    Abstract: The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.
    Type: Application
    Filed: November 6, 2018
    Publication date: March 7, 2019
    Inventors: Pankaj Sharma, Vijay Kumar Khatri, Xuyuan Gu, Yuan Song, Michael Lixin Shen, Jennifer Riggs-Sauthier, Neel K. Anand, Antoni Kozlowski, Aleksandrs Odinecs, Timothy A. Riley, Zhongxu Ren, YongQi Mu, Xiaoming Shen, Xuejun Yuan, Natalia Aurrecoechea, Donogh John Roger O'Mahony, Bo-Liang Deng
  • Patent number: 10220020
    Abstract: The invention relates to (among other things) polymer-des-ethyl sunitinib conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over des-ethyl sunitinib in unconjugated form.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: March 5, 2019
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Sean M. Culbertson, Xiaoming Shen, Samuel P. Mcmanus, Mark A. Wilson
  • Publication number: 20190055354
    Abstract: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.
    Type: Application
    Filed: October 19, 2018
    Publication date: February 21, 2019
    Inventors: Samuel P. McManus, Antoni Kozlowski, J. Milton Harris
  • Publication number: 20190029991
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 31, 2019
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • Patent number: 10189859
    Abstract: The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 29, 2019
    Assignee: Nektar Therapeutics
    Inventors: Pankaj Sharma, Vijay Kumar Khatri, Xuyuan Gu, Yuan Song, Michael Lixin Shen, Jennifer Riggs-Sauthier, Neel K. Anand, Antoni Kozlowski, Aleksandrs Odinecs, Timothy A. Riley, Zhongxu Ren, YongQi Mu, Xiaoming Shen, Xuejun Yuan, Natalia Aurrecoechea, Donogh John Roger O'Mahony, Bo-Liang Deng
  • Publication number: 20190022236
    Abstract: Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Application
    Filed: January 31, 2018
    Publication date: January 24, 2019
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Publication number: 20190008822
    Abstract: Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.
    Type: Application
    Filed: September 7, 2018
    Publication date: January 10, 2019
    Inventors: Antoni Kozlowski, Timothy A. Riley, Samuel P. McManus
  • Patent number: 10144804
    Abstract: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: December 4, 2018
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski, J. Milton Harris
  • Publication number: 20180327546
    Abstract: Provided herein are polymeric ?-hydroxy aldehyde or ?-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the ?-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 15, 2018
    Inventors: Sean M. Culbertson, Xiaoming Shen, Antoni Kozlowski, Samuel P. McManus
  • Patent number: 10098865
    Abstract: Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: October 16, 2018
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Timothy A. Riley, Samuel P. McManus
  • Publication number: 20180282476
    Abstract: Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(C?O)OR?, wherein R? is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.
    Type: Application
    Filed: June 5, 2018
    Publication date: October 4, 2018
    Inventors: J. Milton Harris, Antoni Kozlowski, Lihong Guo
  • Patent number: 10039737
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: August 7, 2018
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • Patent number: 10035880
    Abstract: Provided are methods of preparing heterobifunctional poly(ethylene glycol) derivatives (e.g., HO-PEG-OCH2CO2H) by alkylating poly(ethylene glycol). A method comprises: (a) synthesizing Ar—CR1R2O-Poly-OH (e.g., Bz-PEG-OH, where Bz is benzyl) by forming a polymer Poly (e.g., HO-PEG-OH) onto the aryl methyl oxide ion, Ar—CR1R2O?; (b) alkylating Ar—CR1R2O-Poly-OH to form Ar—CR1R2—O-poly-OR9 (e.g., Bz-O-PEG-OCH2CO2(CH3)3); (c) converting the Ar—CR1R2O— moiety to —OH by acid-catalyzed hydrolysis or hydrogenolysis to form a new mixture of R9O-PEG-OH and R9O-PEG-OR9 (e.g., HO-PEG-OCH2CO2H and HO2CCH2O-PEG-OCH2CO2H); and (d) optionally, isolating the R9O-PEG-OH product formed in (c). The method of the present invention obviates the extensive and laborious purification prior art steps normally required to remove HO-Poly-OH (e.g., HO-PEG-OH) from a preparation of the PEG derivatives.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: July 31, 2018
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Antoni Kozlowski
  • Patent number: 10011682
    Abstract: Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(C?O)OR?, wherein R? is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: July 3, 2018
    Assignee: NEKTAR THERAPEUTICS
    Inventors: J. Milton Harris, Antoni Kozlowski, Lihong Guo
  • Patent number: 9913913
    Abstract: A method for preparing a polymeric reagent is provided, which method includes the optional step of forming an N-hydroxysuccinimdyl ester derivative. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 13, 2018
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles