Patents by Inventor Antonio De Flora
Antonio De Flora has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11032021Abstract: The invention relates to the use of a very low dosage form of abscisic acid (ABA) or an in vivo hydrolysable conjugate thereof, preferably ABA-glucosyl ester (ABA-GE), for nutracentic/therapeutic use for controlling and/or preventing hyperglycaemia and weight gain in response to sugar intake with a reduction in insulin secret and an increase in muscle performance.Type: GrantFiled: January 28, 2019Date of Patent: June 8, 2021Assignee: NUTRAVIS S.R.L.Inventors: Elena Zocchi, Mirko Magnone, Umberto Benatti, Giovanni Del Re, Antonio De Flora
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Publication number: 20190280799Abstract: The invention relates to the use of a very low dosage form of abscisic acid (ABA) or an in vivo hydrolysable conjugate thereof, preferably ABA-glucosyl ester (ABA-GE), for nutracentic/therapeutic use for controlling and/or preventing hyperglycaemia and weight gain in response to sugar intake with a reduction in insulin secret and an increase in muscle performance.Type: ApplicationFiled: January 28, 2019Publication date: September 12, 2019Applicant: NUTRAVIS S.R.L.Inventors: Elena Zocchi, Mirko Magnone, Umberto Benatti, Giovanni Del Re, Antonio De Flora
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Publication number: 20180183541Abstract: A method comprising, receiving digital-electrical input symbols of a stream of input symbols, the input symbols corresponding to signal points of a symbol constellation. The method also comprises classifying the input symbols, wherein a first symbol class comprises input symbols corresponding to signal points that are variant to rotation of the symbol constellation, and, a second symbol class comprises input symbols corresponding to signal points that are invariant to rotation of the symbol constellation. The method also comprises applying selective differential coding only to those input symbols of the first symbol class.Type: ApplicationFiled: July 17, 2015Publication date: June 28, 2018Applicant: Nutravis S.r.l.Inventors: Elena Zocchi, Mirko Magnone, Umberto Benatti, Giovanni Del Re, Antonio De Flora
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Publication number: 20170155468Abstract: A method comprising, receiving digital-electrical input symbols of a stream of input symbols, the input symbols corresponding to signal points of a symbol constellation. The method also comprises classifying the input symbols, wherein a first symbol class comprises input symbols corresponding to signal points that are variant to rotation of the symbol constellation, and, a second symbol class comprises input symbols corresponding to signal points that are invariant to rotation of the symbol constellation. The method also comprises applying selective differential coding only to those input symbols of the first symbol class.Type: ApplicationFiled: July 17, 2015Publication date: June 1, 2017Applicant: Nutravis S.r.l.Inventors: Elena Zocchi, Mirko Magnone, Umberto Benatti, Giovanni Del Re, Antonio De Flora
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Patent number: 7868163Abstract: The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD+.Type: GrantFiled: April 28, 2006Date of Patent: January 11, 2011Assignees: Universita' Degli Studi Di Genova, Centro Biotecnologie AvanzateInventors: Giovanna Basile, Umberto Benatti, Santina Bruzzone, Gianluca Damonte, Antonio De Flora, Ernesto Fattorusso, Luisa Franco, Lucrezia Guida, Orazio Taglialatela-Scafati, Elena Zocchi
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Patent number: 7786042Abstract: The invention relates to a novel use of fluridone—compound known per se and used as an aquatic erbicide—in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an inhibitor.Type: GrantFiled: October 6, 2006Date of Patent: August 31, 2010Assignee: Universita' Degli Studi Di GenovaInventors: Elena Zocchi, Lucrezia Guida, Santina Bruzzone, Sonia Scarfi′, Mirko Magnone, Giovanna Basile, Umberto Benatti, Antonio De Flora, Iliana Moreschi, Luisa Franco, Annalisa Salis
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Publication number: 20080242705Abstract: The invention relates to a novel use of fluridone—compound known per se and used as an aquatic erbicide—in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an inhibitor.Type: ApplicationFiled: October 6, 2006Publication date: October 2, 2008Inventors: Elena Zocchi, Lucrezia Guida, Santina Bruzzone, Sonia Scarfi, Mirko Magnone, Giovanna Basile, Umberto Benatti, Antonio De Flora, Illana Moreschi, Luisa Franco, Annalisa Salis
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Publication number: 20080194509Abstract: The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD+.Type: ApplicationFiled: April 28, 2006Publication date: August 14, 2008Applicants: UNIVERSITA' DEGLI STUDI DI GENOVA, CENTRO BIOTECNOLOGIE AVANZATEInventors: Giovanna Basile, Umberto Benatti, Santina Bruzzone, Gianluca Damonte, Antonio De Flora, Ernesto Fattorusso, Luisa Franco, Lucrezia Guida, Orazio Taglialatela-Scafati, Elena Zocchi
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Patent number: 6593307Abstract: The present invention provides a compound of formula I: wherein A, D, R1, and R2 are as defined in the specification; or a salt or a detectably labeled derivative thereof. The invention also provides methods of using the compound of formula I or a salt or a detectably labeled derivative thereof for promoting the proliferation of hemopoietic progenitor cells without cell differentiation.Type: GrantFiled: October 27, 2000Date of Patent: July 15, 2003Assignee: Regents of the University of MinnesotaInventors: Timothy F. Walseth, Antonio De Flora, Elena Zocchi, Marina Podesta, Long Wong, Robert A. Aarhus, Hon Cheung Lee
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Patent number: 6080731Abstract: 5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthing-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.Type: GrantFiled: July 1, 1998Date of Patent: June 27, 2000Assignees: Biosearch Italia, S.p.A., University of GenoaInventors: Antonio De Flora, Umberto Benatti, Marco Giovine
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Patent number: 6040297Abstract: 5,5'-Pyrophosphates of non-naturally occurring nucleosides selected from 1-(1-thyminyl)-3-azido-2, 3-dideoxy-D-riboside, 1(5-fluoro-1-uracilyl)-2, 3-dideoxy-D-riboside, 1-(1-uracilyl)-3-azido-2, 3-dideoxy-D-riboside, 1-(9-guaninyl)-2, 3-dideoxy-D-riboside, 1-(9-hypoxanthinyl)-2, 3-dideoxy-D-riboside, 1-(1-cytosinyl)-2, 3-dideoxy-D-riboside, and 1-(9-adeninyl)-2, 3-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutic agents against tumors and retroviral infections including HIV infections. The compounds may be administered as the active ingredients of pharmaceutical compositions or as prodrugs encapsulated within biological carriers, e.g. transformed erythrocytes, for targeting to specific cell populations responsible for the development of the noted pathological disorders.Type: GrantFiled: January 14, 1997Date of Patent: March 21, 2000Assignees: Biosearch Italia, S.p.A., Gruppo Lepetit, S.p.A.Inventors: Antonio De Flora, Umberto Benatti, Marco Giovine