Abstract: The invention relates to a novel method to produce small RNAs targeting virulence factors, essential genes and/or antimicrobial resistance genes of phytopathogens. More specifically, the invention involves the expression of exogenous RNA interference (RNAi) precursor(s) in Chlorella cells, which in turn express and release Extracellular Vesicle (EV)-embedded antimicrobial small RNAs. These EVs can be collected from the cell-free medium of Chlorella cultures, and further concentrated and purified for biocontrol applications. Importantly, Chlorella EVs protect small RNAs from ribonuclease-mediated digestion, indicating that these lipid-based particles not only act as natural vectors of small RNAs towards pathogenic cells, but also presumably limit their degradation in the environment. The invention can thus likely be used to reduce the pathogenicity and growth of a wide range of pathogens or, potentially, to enhance beneficial effects and growth of plant-associated symbiotic and commensal microbes.

Abstract: A vehicle occupant restraint system comprises an airbag module (12) which includes a frontally acting airbag (16) as well as an inflator (18) which upon activation supplies filling gas for the airbag (16), wherein prior to activation the airbag (16) is folded into an airbag package (14) and is disposed in the area of a sun visor (30) of a vehicle at a roof liner (23) of the vehicle. The airbag package (14) and the inflator (18) are substantially positioned, when viewed in the longitudinal vehicle direction (R), between a pivot axis (28) of the sun visor (30) and a windshield (26) of the vehicle.

Abstract: The present invention belongs to the field of biomedical chemistry and provides modified peptides and dimers thereof derived from the amino acid sequence of the protein ADAM-12, their compositions, process of synthesis and their use in medicine, specifically in the inhibition of cancer growth and/or the reduction or inhibition of cancer cell invasion and metastasis in different cancers.

Abstract: The present disclosure relates to certain AHR agonist compounds, their method of making, and to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases, such as psoriasis and atopic dermatitis.

Abstract: A method includes obtaining a compute graph for computing a first tensor, identifying in the graph a reduction operation in at least one dimension of the first tensor, locating, at the operation, a cut point that cuts the graph into first and second portions, and determining a plurality of slices of the first tensor. The method also includes backpropagating the cut point through the graph to define a plurality of first graph pieces for the first portion, each particular first graph piece representing a computation of a particular slice of the plurality of slices based on a particular portion of a plurality of portions of a second tensor. The method further includes defining one or more second graph pieces to combine outputs of the first graph pieces, and executing the first graph pieces and the second graph pieces to execute the first portion of the compute graph.

Abstract: A vehicle occupant restraint system includes an airbag module (18) that is disposed in a roof area (16) of a vehicle and is assigned to a front seat (14). The airbag module (18) comprises an airbag (20) that is disposed so that it deploys in the vehicle longitudinal direction (L) in front of a vehicle occupant (12) seated in the front seat (14), wherein a baffle (24) of the airbag (20) in the filled state is aligned transversely to the vehicle longitudinal direction (L) and faces the vehicle occupant (12). In a situation of restraint, it can be decided whether the airbag (20) is filled depending on whether the vehicle occupant (12) is touching a steering wheel (38) of the vehicle, wherein a steering wheel airbag is exclusively filled when a contact with the steering wheel (38) is detected.

Abstract: A method includes obtaining a graph that includes a plurality of nodes each representing a computational job and connected to one or more other nodes via edges. Each edge represents a dependency between two connected nodes. For each computing device of a distributed computing system, the method includes obtaining resource characteristics. The method includes slicing, based on the dependencies of connected nodes, the graph into a plurality of sub-graphs each including one or more nodes. For each respective sub-graph, the method includes determining a computational cost of the respective sub-graph and distributing, based on the computational cost and the resource characteristics, the respective sub-graph to the respective one of the computing devices. The method includes receiving a respective result from the respective one of the computing devices based on execution of the computational jobs. The method includes determining a total result based on each respective result.

Abstract: A vehicle occupant restraint system comprises an airbag module (12) which includes an airbag (16) as well as an inflator (18) which upon activation supplies filling gas for the airbag (16). The airbag (16) is folded prior to activation into an airbag package (14) so that a main package (48) which contains a restraint part (52) of the airbag (16) constituting a major part of the airbag volume as well as a connecting portion (50) is formed which comprises a neck (54) of the airbag (16) connecting the restraint part (52) to the inflator (18), wherein the restraint part (52) is folded differently from the neck (54).

Abstract: A vehicle occupant restraint system comprises an airbag module (12) including an inflator (18) and a frontally acting airbag (16), wherein the airbag (16) includes an inflator-side inflation end (46) as well as a first free end (56) located in the inflated state of the airbag (16) within a vehicle interior. In a first period during deployment of the airbag (16), the first free end (56) is still connected via a tether (74) to the airbag module (12), wherein the tether (74) becomes detached upon reaching a predetermined tensile force.

Abstract: A flexible wrapping of an airbag (16) of a vehicle occupant restraint system (10) comprises a holding compartment for a folded airbag package (14) formed by a holding bag (104) and an airbag package fixation (124), an inflator fixation (114) formed by projecting retaining tabs (112) as well as at least one fixing portion (130) for fixing an airbag module (12) to a vehicle. For inserting the airbag package (14) into the wrapping (20) an intermediate cover made of a coherent piece of fabric is used into which the airbag package (14) is wrapped along with the inflator (18). The subassembly consisting of the intermediate cover, the airbag package (14) and the inflator (18) is inserted into the wrapping (20). Subsequently, the intermediate cover is removed from between the wrapping (20) and the airbag package (14) again.

Abstract: This invention relates to the delivery of a composition, preferably a pharmaceutical composition, comprising D-pinitol, D-Chiro inositol or myo-inositol or any pharmaceutically acceptable salt thereof, for use in the treatment or prevention of disorders, diseases or conditions responsive to the stimulation of the ghrelin receptor in a subject in need thereof.

Abstract: A vehicle occupant restraint system comprises an airbag module (12) including an inflator (18) and a frontally acting airbag (16), wherein the airbag (16) includes an inflator-side inflation end (46) as well as a first free end (56) located in the inflated state of the airbag (16) within a vehicle interior. In a first period during deployment of the airbag (16), the first free end (56) is still connected via a tether (74) to the airbag module (12), wherein the tether (74) becomes detached upon reaching a predetermined tensile force.

Abstract: A flexible wrapping of an airbag (16) of a vehicle occupant restraint system (10) comprises a holding compartment for a folded airbag package (14) formed by a holding bag (104) and an airbag package fixation (124), an inflator fixation (114) formed by projecting retaining tabs (112) as well as at least one fixing portion (130) for fixing an airbag module (12) to a vehicle. For inserting the airbag package (14) into the wrapping (20) an intermediate cover made of a coherent piece of fabric is used into which the airbag package (14) is wrapped along with the inflator (18). The subassembly consisting of the intermediate cover, the airbag package (14) and the inflator (18) is inserted into the wrapping (20). Subsequently, the intermediate cover is removed from between the wrapping (20) and the airbag package (14) again.

Abstract: A vehicle occupant restraint system comprises an airbag module (12) which includes an airbag (16) as well as an inflator (18) which upon activation supplies filling gas for the airbag (16). The airbag (16) is folded prior to activation into an airbag package (14) so that a main package (48) which contains a restraint part (52) of the airbag (16) constituting a major part of the airbag volume as well as a connecting portion (50) is formed which comprises a neck (54) of the airbag (16) connecting the restraint part (52) to the inflator (18), wherein the restraint part (52) is folded differently from the neck (54).

Abstract: A vehicle occupant restraint system comprises an airbag module (12) which includes a frontally acting airbag (16) as well as an inflator (18) which upon activation supplies filling gas for the airbag (16), wherein prior to activation the airbag (16) is folded into an airbag package (14) and is disposed in the area of a sun visor (30) of a vehicle at a roof liner (23) of the vehicle. The airbag package (14) and the inflator (18) are substantially positioned, when viewed in the longitudinal vehicle direction (R), between a pivot axis (28) of the sun visor (30) and a windshield (26) of the vehicle.

Abstract: The present disclosure provides a capacitor-less AC/DC converter power supply system. The power supply system includes one or more rectifier cells having inductive and synchronous elements, and removing any capacitive filter elements thus ensuring a very high Mean Time Before Failure (MTBF) on the rectifier stage. The output voltage and current generated by the one or more inductive cells is a DC signal having a ripple amount dependent upon the number of cells implemented.

Abstract: The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof.

Abstract: A system and apparatus for generating electricity via at least one piezoelectric cable embedded within the tires of a vehicle is described. Electricity is converted from pressure exerted by the weight of the car compressing on the outer circumference of the tires as the tire rotates. The electricity is converted via the piezoelectric cable, and is then conveyed by induction to reinforce and supplement the electrical systems of the vehicle. The apparatus is configured as a complete circuit, facilitating the use of current within the circuit to harden or soften the piezoelectric cable, and therefore stiffen or soften the overall ride of the tires equipped with the apparatus.

Abstract: The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof.

Abstract: Computer-assisted method for optimizing surfaces of composite-material structures as part of a design process that includes the following stages: a) Providing a multi-cell surface (11) of the structure obtained using aerodynamic calculations; b) Transforming said multi-cell surface (11) into an optimized surface (13) with fewer cells, concatenating contiguous cells and maintaining point and tangent continuity between them; c) Using said optimized surface (13) as geometric master when designing the components of the structure. The method is particularly applicable to the design of structures with a plurality of components and in particular fuselages of aircraft made of composite material. The invention also relates to a computer program for performing the method.