Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapaptotic capacities thereof, in the treatment of chronic psoriatic plaques.

Abstract: The present invention refers to a process and apparatus for manufacturing plastic articles through the rotational molding method, and is more particularly addressed to a process and apparatus of rotomoulding in furnace for manufacturing containers with multiple layers. The apparatus of the present invention uses a series of bins for the introduction of the materials to be molten on the molds, which are controlled by a computerized control panel.

Abstract: Pulse sequences are applied to a fluid in an earth formation in a static magnetic field and NMR spin echo signals are obtained. The signals are processed to give a distribution of a relaxation time at a plurality of depths. Semblance between the distributions and a log of a formation property are used to identify depths at which portions of the distributions are similar to the formation property logs.

Abstract: The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapaptotic capacities thereof, in the treatment of chronic psoriatic plaques.

Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, dermatitis.

Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.

Abstract: The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent. Also disclosed are compositions comprising administration of at least one 2,5-dihydroxybenzene sulfonic acid compound, or a pharmaceutically acceptable salt thereof, and, at least one therapeutic agent.

Abstract: Pulse sequences are applied to a fluid in an earth formation in a static magnetic field and NMR spin echo signals are obtained. The signals are processed to give a distribution of relaxation time at each of the plurality of depths. A quasi-DNA is obtained by autoscaling and a nonlinear mapping of T2 component logs and non-NMR logs. Similarities between the quasi-DNA of the two types of logs are used to estimate formation lithology and fluids.

Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.

Abstract: The present invention relates to the use of a compound of Formula (IIV) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of any of the diseases selected from the group consisting of macular degeneration, corneal neovascularization or angiogenesis, iris neovascularization or angiogenesis, retinal neovascularization or angiogenesis, diabetic proliferative retinopathy and non-diabetic proliferative retinopathy.

Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, psoriasis.

Abstract: Crankshaft bearing cap presenting on one of its faces a semi-cylindrical notch, formed by powder metallurgy with an iron powder blend molded by compaction and sintering, and partially infiltrated with Cu, being the area adjacent to the area around the notch, the one with highest Cu content. A method for manufacturing main bearing caps by infiltration of Cu including the steps of placing the molded cap so that the axis of the semi-cylindrical notch extends in a horizontal direction and the notch cavity is in the upwards position. Placing high Cu content tablets on the upper face of the cap and on the cylindrical arch and sintering of the cap and Cu tablets system.

Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, actinic keratosis.

Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.

Abstract: The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapoptotic capacities thereof, in the treatment of chronic psoriatic plaques.

Abstract: Disclosed is a non-lineal statistical independent component (ICA) analysis methodology for calculating T2 or T1 distributions of nuclear magnetic resonance logs. In one aspect, the invention employs a classical blind source separation (BSS) approach with the input data (T2 or T1 distributions) being considered not only horizontally (in relaxation time units), but also vertically (in depth). The statistical variations are used for separating the principal independent components and their corresponding weighting matrix. The result of such ICA based BSS is an efficient separation of T2 components correlative to the presence of particular conditions (e.g., clay bound water, heavy oil, capillary bound water, free water, mud filtrate (water and oil), and noise). Individual saturation of estimated fluids can be calculated from the weighting matrix generated in accordance with the invention.

Abstract: Pulse sequences are applied to a fluid in an earth formation in a static magnetic field and NMR spin echo signals are obtained. The signals are processed to give a distribution of a relaxation time at a plurality of depths. Semblance between the distributions and a log of a formation property are used to identify depths at which portions of the distributions are similar to the formation property logs.

Abstract: Pulse sequences are applied to a fluid in an earth formation in a static magnetic field and NMR spin echo signals are obtained. The signals are inverted to give T2 distributions at a plurality of depths. Similarities between logs of the T2 bins with resistivity and/or gamma ray logs are used to identify and subtract contributions to the NMR signal from oil. having internal gradients. From the received signals, relaxation and diffusion characteristics of the fluid are determined. The determination takes into account the internal field gradients. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

Abstract: Systems and methods are provided that build and publish online documents. Source files of the online documents are automatically built into a book and published on a web site for review. A report regarding the build is provided to the author of the documents. The author can use the report to determine whether the build was successful, and whether manual intervention is necessary. The books are also archived.