Patents by Inventor Antonio Verdini

Antonio Verdini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components
    Patent number: 7968103
    Abstract: The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the ?-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: June 28, 2011
    Inventors: Otto Westphal, Josette Westphal, legal representative, Alexander Westphal, legal representative, Thierry Walli, Reginald Gorczynski, Silke Muller, Jean-Pierre Mach, Alfred Hartman, Wolfgang Bessler, Petra Hofmann, Ulrich Zahringer, Christian Alexander, Ulrich vor dem Esche, Artur J. Ulmer, Antonio Verdini
  • Compositions Comprising Fetal Hemoglobin and Bacterial Endotoxin and Optionally Additional Fetal Liver Components
    Publication number: 20080075742
    Abstract: The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the ?-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition.
    Type: Application
    Filed: February 18, 2004
    Publication date: March 27, 2008
    Inventors: Otto Westphal, Josette Mottier Westphal, Alexander Westphal, Thierry Walli, Reginald Gorczynski, Silke Muller, Jean-Pierre Mach, Alfred Hartman, Wolfgang Bessler, Petra Hofmann, Ulrich Zahringer, Christian Alexander, Ulrich vor dem Esche, Artur J. Ulmer, Antonio Verdini
  • Process for folding chemically synthesized polypeptides
    Publication number: 20050239162
    Abstract: A method is provided for folding chemically synthesized polypeptides having two or more derivatized cysteine residues by contacting with a reducing agent in a folding buffer having a predetermined pH and temperature.
    Type: Application
    Filed: May 19, 2005
    Publication date: October 27, 2005
    Applicant: RMF DICTAGENE S.A.
    Inventors: Antonio Verdini, Giampetro Corradin, Mario Roggero
  • Process for folding chemically synthesized polypeptides
    Publication number: 20020082384
    Abstract: A method is provided for folding chemically synthesized polypeptides having two or more derivatized cysteine residues by contacting with a reducing agent in a folding buffer having a predetermined pH and temperature.
    Type: Application
    Filed: November 27, 2001
    Publication date: June 27, 2002
    Inventors: Antonio Verdini, Giampietro Corradin, Mario Roggero
  • New thymopentin retro-inverso analogs and fragments thereof, a process of preparation of the new compounds and the intermediates obtained therein
    Patent number: 5013723
    Abstract: New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts.The new compounds are enzyme-resistant immunomodulatory peptides.
    Type: Grant
    Filed: March 15, 1988
    Date of Patent: May 7, 1991
    Assignees: Eniricerche S.p.A., Sclavo S.p.A.
    Inventors: Alessandro Sisto, Antonio Verdini