Patents by Inventor Aram Chung
Aram Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11951479Abstract: The present invention relates to a method of inhibiting, delaying, or reversing cellular senescence that includes having an isolated cell flow through a microchannel, and crashing the cell in flow into an impact surface installed on a flow path of the cell to apply a physical impact to the cell, resulting in inhibiting, delaying, or reversing senescence of the cell, while maintaining high biological activity, and in particular, it relates to a method that can further increase the value of a stem cell as a therapeutic cell for various degenerative diseases by maintaining undifferentiated state of the stem cell even during a long-term culture period to maintain multipotency, and to the cells obtained by the method.Type: GrantFiled: July 29, 2021Date of Patent: April 9, 2024Assignees: KONKUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATIONInventors: Ssang-Goo Cho, Aram Chung, Kyung Min Lim, Geunho Kang, Soobin Jang
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Publication number: 20230001416Abstract: Provided is a method of transferring a material into cells, comprising the steps of: forming droplets consisting of a material to be transferred and cells; and a step of subjecting the formed droplets to deformation, thereby transferring the material to be transferred, into the cells.Type: ApplicationFiled: November 4, 2020Publication date: January 5, 2023Applicant: Korea University Research and Business FoundationInventors: Aram CHUNG, Byeong-Ju JOO, Ha-Sung LEE
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Publication number: 20220177819Abstract: There is provided a microfluidic system delivering external materials into a cell by cell mechanoporation using inertia, the microfluidic system including a fluidic channel structure through which a solution containing a cell and external materials flows continuously, in which the fluidic channel structure includes a junction between one or more channels, a localized vortex is generated near an interface of the junction, the cell is deformed by the vortex, and transient discontinuities are generated in a cell membrane by the vortex and the external materials are introduced into the cell by solution exchange between the cell and fluid around the cell.Type: ApplicationFiled: March 11, 2020Publication date: June 9, 2022Applicant: MxT BIOTECHInventors: Aram CHUNG, Geoum-Young KANG, Jeong-Soo HUR
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Publication number: 20220032304Abstract: The present invention relates to a method of inhibiting, delaying, or reversing cellular senescence that includes having an isolated cell flow through a microchannel, and crashing the cell in flow into an impact surface installed on a flow path of the cell to apply a physical impact to the cell, resulting in inhibiting, delaying, or reversing senescence of the cell, while maintaining high biological activity, and in particular, it relates to a method that can further increase the value of a stem cell as a therapeutic cell for various degenerative diseases by maintaining undifferentiated state of the stem cell even during a long-term culture period to maintain multipotency, and to the cells obtained by the method.Type: ApplicationFiled: July 29, 2021Publication date: February 3, 2022Inventors: Ssang-Goo CHO, Aram CHUNG, Kyung Min LIM, Geunho KANG, Soobin JANG
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Publication number: 20210341376Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: ApplicationFiled: March 12, 2021Publication date: November 4, 2021Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T.K. Tse, Aram Chung
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Patent number: 10969327Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: GrantFiled: April 3, 2019Date of Patent: April 6, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T. K. Tse, Aram Chung
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Publication number: 20190250092Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: ApplicationFiled: April 3, 2019Publication date: August 15, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T.K. Tse, Aram Chung
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Patent number: 10295455Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: GrantFiled: March 28, 2017Date of Patent: May 21, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T. K. Tse, Aram Chung
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Patent number: 10107735Abstract: A system for deforming and analyzing particles includes a substrate defining an inlet, and an outlet; a fluidic pathway fluidly coupled to the inlet and the outlet and defining a delivery region upstream of a deformation region configured to deform particles, wherein the fluidic pathway comprises a first branch configured to generate a first flow, and a second branch configured to generate a second flow that opposes the first flow, wherein an intersection of the first flow and the second flow defines the deformation region; a detection module including a sensor configured to generate a morphology dataset characterizing deformation of the particles, and a photodetector configured to generate a fluorescence dataset characterizing fluorescence of the particles; and a processor configured to output an analysis of the plurality of particles based at least in part on the deformation dataset and the fluorescent dataset for the plurality of particles.Type: GrantFiled: December 13, 2016Date of Patent: October 23, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T. K. Tse, Aram Chung
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Publication number: 20170234788Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: ApplicationFiled: March 28, 2017Publication date: August 17, 2017Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T.K. Tse, Aram Chung
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Patent number: 9638620Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: GrantFiled: July 17, 2015Date of Patent: May 2, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T. K. Tse, Aram Chung
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Publication number: 20170089822Abstract: A system for deforming and analyzing particles includes a substrate defining an inlet, and an outlet; a fluidic pathway fluidly coupled to the inlet and the outlet and defining a delivery region upstream of a deformation region configured to deform particles, wherein the fluidic pathway comprises a first branch configured to generate a first flow, and a second branch configured to generate a second flow that opposes the first flow, wherein an intersection of the first flow and the second flow defines the deformation region; a detection module including a sensor configured to generate a morphology dataset characterizing deformation of the particles, and a photodetector configured to generate a fluorescence dataset characterizing fluorescence of the particles; and a processor configured to output an analysis of the plurality of particles based at least in part on the deformation dataset and the fluorescent dataset for the plurality of particles.Type: ApplicationFiled: December 13, 2016Publication date: March 30, 2017Applicant: CytoVale Inc.Inventors: Dino Di Carlo, Daniel R. Gossett, Henry T.K. Tse, Aram Chung
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Patent number: 9464977Abstract: A system for deforming and analyzing particles includes a substrate defining an inlet, and an outlet; a fluidic pathway fluidly coupled to the inlet and the outlet and defining a delivery region upstream of a deformation region configured to deform particles, wherein the fluidic pathway comprises a first branch configured to generate a first flow, and a second branch configured to generate a second flow that opposes the first flow, wherein an intersection of the first flow and the second flow defines the deformation region; a detection module including a sensor configured to generate a morphology dataset characterizing deformation of the particles, and a photodetector configured to generate a fluorescence dataset characterizing fluorescence of the particles; and a processor configured to output an analysis of the plurality of particles based at least in part on the deformation dataset and the fluorescent dataset for the plurality of particles.Type: GrantFiled: October 18, 2013Date of Patent: October 11, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T. K. Tse, Aram Chung
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Publication number: 20150355073Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: ApplicationFiled: July 17, 2015Publication date: December 10, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T.K. Tse, Aram Chung
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Patent number: 9151705Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: GrantFiled: October 18, 2013Date of Patent: October 6, 2015Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T. K. Tse, Aram Chung
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Publication number: 20140315287Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.Type: ApplicationFiled: October 18, 2013Publication date: October 23, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Daniel R. Gossett, Henry T.K. Tse, Aram Chung
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Publication number: 20140113324Abstract: A system for deforming and analyzing particles includes a substrate defining an inlet, and an outlet; a fluidic pathway fluidly coupled to the inlet and the outlet and defining a delivery region upstream of a deformation region configured to deform particles, wherein the fluidic pathway comprises a first branch configured to generate a first flow, and a second branch configured to generate a second flow that opposes the first flow, wherein an intersection of the first flow and the second flow defines the deformation region; a detection module including a sensor configured to generate a morphology dataset characterizing deformation of the particles, and a photodetector configured to generate a fluorescence dataset characterizing fluorescence of the particles; and a processor configured to output an analysis of the plurality of particles based at least in part on the deformation dataset and the fluorescent dataset for the plurality of particles.Type: ApplicationFiled: October 18, 2013Publication date: April 24, 2014Applicant: The Regents Of The University Of CaliforniaInventors: Dino Di Carlo, Daniel R. Gossett, Henry T.K. Tse, Aram Chung