Patents by Inventor Ariel A. Ewenson

Ariel A. Ewenson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8524898
    Abstract: Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Further disclosed are a process of preparing such iminium-type coupling agents and their use in the preparation of polypeptides and/or polynucleotides.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: September 3, 2013
    Assignee: Luxembourg Bio Technologies Ltd.
    Inventors: Fernando Albericio, Ayman El-Faham, Yoav Luxembourg, Ariel Ewenson
  • Publication number: 20100144588
    Abstract: Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Further disclosed are a process of preparing such iminium-type coupling agents and their use in the preparation of polypeptides and/or polynucleotides.
    Type: Application
    Filed: May 15, 2008
    Publication date: June 10, 2010
    Applicant: LUXEMBOURG BIO TECHNOLOGIES LTD.
    Inventors: Fernando Albericio, Ayman El-Faham, Yoav Luxembourg, Ariel Ewenson
  • Patent number: 7304163
    Abstract: Novel phosphonium salts of benzotraizoles, which are highly reactive coupling agents, and are particularly useful in peptide synthesis, are disclosed. Further disclosed is a process of preparing the novel phosphonium salts and methods utilizing same for preparing peptides.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: December 4, 2007
    Assignee: Luxembourg Industries Ltd.
    Inventors: Yoav Luxembourg, Youval Shvo, Ariel Ewenson
  • Publication number: 20070043207
    Abstract: Novel phosphonium salts of benzotraizoles, which are highly reactive coupling agents, and are particularly useful in peptide synthesis, are disclosed. Further disclosed is a process of preparing the novel phosphonium salts and methods utilizing same for preparing peptides.
    Type: Application
    Filed: September 30, 2005
    Publication date: February 22, 2007
    Applicant: Luxembourg Industries Ltd.
    Inventors: Yoav Luxembourg, Youval Shvo, Ariel Ewenson
  • Patent number: 6399835
    Abstract: Processes for the electrophilic substitution of aromatic compounds, such as alkylation, with a desired substituent are disclosed. The processes include contacting the aromatic compound, a precursor of the desired substituent and an aqueous reagent containing zinc halide at elevated temperatures such as above 50° C.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: June 4, 2002
    Assignee: Bromine Compounds Ltd.
    Inventors: Ariel Ewenson, David Itzhak, Miriam Freiberg Bergstein, Asher Shushan, Bertha Croitoru, David Beneish, Naim Faza
  • Patent number: 5728865
    Abstract: A process for the preparation of octyl p-methoxy cinnamate is provided. The procedure generally concerns reacting p-bromo anisole with acrylic acid; and esterifying the resulting product with 2-ethyl hexanol. Preferred reactants and conditions are provided.
    Type: Grant
    Filed: August 20, 1996
    Date of Patent: March 17, 1998
    Assignee: Bromine Compounds Ltd.
    Inventors: Ariel Ewenson, Bertha Croitoru, Asher Shushan
  • Patent number: 5177258
    Abstract: Biaryl derivatives are produced by coupling an aryl halide in an aqueous alkaline solution in the presence of a palladium catalyst, using formic hydrazide as the reducing agent.
    Type: Grant
    Filed: May 21, 1992
    Date of Patent: January 5, 1993
    Assignee: Bromine Compounds, Ltd.
    Inventors: Abram Becker, Ariel A. Ewenson, Bertha Croitoru