Patents by Inventor Ariel Fernandez

Ariel Fernandez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9189535
    Abstract: Systems, methods and articles of manufacture are disclosed for generating an online analytical processing (OLAP) query against a cube. The cube may have dimensions, each dimension having a hierarchy of members. A report specification may be received against a hierarchy of the cube. An OLAP query may be generated from the report specification. The OLAP query may include projected members not having any descendant at the detail level of the hierarchy, thus producing more accurate results.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: November 17, 2015
    Assignee: International Business Machines Corporation
    Inventor: Ariel Fernandez Ortega
  • Patent number: 9051387
    Abstract: The present invention provides for methods of treating and slowing the onset of heart failure. The inventors have determined that myosin binding to unphosphorylated Myosin Binding Protein C (MyBP-C) plays a key role in the diminution of cardiac contractile force and frequency in heart failure. The present invention provides peptide inhibitors of the MyBP-C/myosin interaction, thereby increasing both cardiac contractile force and frequency in the failing heart, as well as in patients not yet exhibiting frank heart failure.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 9, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Richard L. Moss, Ariel Fernandez
  • Patent number: 8655861
    Abstract: In one example, a method comprises receiving, with a data access service, an input query from an enterprise software application, wherein the data access service is positioned between the enterprise software application and a multidimensional data source; parsing the input query into a parse tree; generating an abstract syntax tree based on the parse tree, the abstract syntax tree comprising input query elements and multidimensional expression query elements based on the input query; performing an evaluation of metadata comprised in the multidimensional expression query elements of the abstract syntax tree; restructuring the abstract syntax tree based on the evaluation of the metadata; executing a query based on the restructured abstract syntax tree on the multidimensional data source; and retrieving a query result set from the multidimensional data source comprising results that are responsive to the query based on the restructured abstract syntax tree.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: February 18, 2014
    Assignee: International Business Machines Corporation
    Inventors: Patrick Burke, Stanley L. Chauvin, David C. Cummings, Ariel Fernandez Ortega
  • Publication number: 20130345135
    Abstract: The present invention provides for methods of treating and slowing the onset of heart failure. The inventors have determined that myosin binding to unphosphorylated Myosin Binding Protein C (MyBP-C) plays a key role in the diminution of cardiac contractile force and frequency in heart failure. The present invention provides peptide inhibitors of the MyBP-C/myosin interaction, thereby increasing both cardiac contractile force and frequency in the failing heart, as well as in patients not yet exhibiting frank heart failure.
    Type: Application
    Filed: March 14, 2013
    Publication date: December 26, 2013
    Inventors: RICHARD L. MOSS, Ariel Fernandez
  • Patent number: 8484157
    Abstract: Systems, methods and articles of manufacture are disclosed for generating an online analytical processing (OLAP) query against a cube. The cube may have dimensions, each dimension having a hierarchy of members. A report specification may be received against a hierarchy of the cube. An OLAP query may be generated from the report specification. The OLAP query may include projected members not having any descendant at the detail level of the hierarchy, thus producing more accurate results.
    Type: Grant
    Filed: September 15, 2012
    Date of Patent: July 9, 2013
    Assignee: International Business Machines Corporation
    Inventor: Ariel Fernandez Ortega
  • Patent number: 8466154
    Abstract: This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: June 18, 2013
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Ariel Fernandez, William Bornmann, Gabriel Lopez-Berestein, Angela Sanguino, Zheng-Hong Peng, Anil K. Sood
  • Publication number: 20130131076
    Abstract: This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.
    Type: Application
    Filed: October 29, 2007
    Publication date: May 23, 2013
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Ariel Fernandez, William Bornmann, Gabriel Lopez-Berestein, Angela Sanguino, Zheng-Hong Peng, Anil K. Sood
  • Publication number: 20130097114
    Abstract: In one example, a method comprises receiving, with a data access service, an input query from an enterprise software application, wherein the data access service is positioned between the enterprise software application and a multidimensional data source; parsing the input query into a parse tree; generating an abstract syntax tree based on the parse tree, the abstract syntax tree comprising input query elements and multidimensional expression query elements based on the input query; performing an evaluation of metadata comprised in the multidimensional expression query elements of the abstract syntax tree; restructuring the abstract syntax tree based on the evaluation of the metadata; executing a query based on the restructured abstract syntax tree on the multidimensional data source; and retrieving a query result set from the multidimensional data source comprising results that are responsive to the query based on the restructured abstract syntax tree.
    Type: Application
    Filed: July 10, 2012
    Publication date: April 18, 2013
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Patrick Burke, Stanley L. Chauvin, David C. Cummings, Ariel Fernandez Ortega
  • Patent number: 8359305
    Abstract: In one example, a method comprises receiving, with a data access service, an input query from an enterprise software application, wherein the data access service is positioned between the enterprise software application and a multidimensional data source; parsing the input query into a parse tree; generating an abstract syntax tree based on the parse tree, the abstract syntax tree comprising input query elements and multidimensional expression query elements based on the input query; performing an evaluation of metadata comprised in the multidimensional expression query elements of the abstract syntax tree; restructuring the abstract syntax tree based on the evaluation of the metadata; executing a query based on the restructured abstract syntax tree on the multidimensional data source; and retrieving a query result set from the multidimensional data source comprising results that are responsive to the query based on the restructured abstract syntax tree.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: January 22, 2013
    Assignee: International Business Machines Corporation
    Inventors: Patrick Burke, Stanley L. Chauvin, David C. Cummings, Ariel Fernandez Ortega
  • Publication number: 20130013554
    Abstract: Systems, methods and articles of manufacture are disclosed for generating an online analytical processing (OLAP) query against a cube. The cube may have dimensions, each dimension having a hierarchy of members. A report specification may be received against a hierarchy of the cube. An OLAP query may be generated from the report specification. The OLAP query may include projected members not having any descendant at the detail level of the hierarchy, thus producing more accurate results.
    Type: Application
    Filed: September 15, 2012
    Publication date: January 10, 2013
    Applicant: International Business Machines Corporation
    Inventor: Ariel Fernandez Ortega
  • Publication number: 20110131173
    Abstract: Systems, methods and articles of manufacture are disclosed for generating an online analytical processing (OLAP) query against a cube. The cube may have dimensions, each dimension having a hierarchy of members. A report specification may be received against a hierarchy of the cube. An OLAP query may be generated from the report specification. The OLAP query may include projected members not having any descendant at the detail level of the hierarchy, thus producing more accurate results.
    Type: Application
    Filed: December 1, 2009
    Publication date: June 2, 2011
    Applicant: INTERNATION BUSINESS MACHINES CORPORATION
    Inventor: ARIEL FERNANDEZ ORTEGA