Abstract: A method is provided for the treatment of postmenopausal disorders which comprises administering to a woman in single, oral, daily dose form during an uninterrupted consecutive sequence of 90 days.(a) a daily, oral, dose in an uninterrupted consecutive sequence for 69 days starting on the first day of a naturally occurring or synthetic estrogenic compound effective in the prevention of climacteric symptoms;(b) a daily, oral dose in an uninterrupted consecutive sequence from the 70th day to the 83rd day following said first day, of a naturally occurring or synthetic estrogenic compound and a compound having progestational activity effective in preventing the development of endometrial hyperplasia; and optionally(c) a daily, oral dose in an uninterrupted consecutive sequence from the 84th to the 90th day following said first day, of a compound free of estrogen and progestogen.