Abstract: The systems and methods provide a dynamic process for obtaining and managing informed consent documentation. In general, the dynamic informed consent process (DICP) makes use of an intermediary organization, e.g., a trusted intermediary, which: (a) provides ICFs which have been dynamically generated for a specified trial or medical procedure and based on particular state or federal requirements, if any; and (b) archives copies of signed ICFs. In certain preferred embodiments, there may also be a procedure to provide training materials, such as audio or video presentations, to be viewed by prospective participants. In certain preferred embodiments, the process also includes contacting subjects who have signed ICFs in the event that there is a change of circumstance which the subject may deem material to whether s/he would continue to consent, or whether the participant needs to provide a different type of consent to participate in particular event or trial.

Abstract: The systems and methods provide a dynamic process for obtaining and managing informed consent documentation. In general, the dynamic informed consent process (DICP) makes use of an intermediary organization, e.g., a trusted intermediary, which: (a) provides ICFs which have been dynamically generated for a specified trial or medical procedure and based on particular state or federal requirements, if any; and (b) archives copies of signed ICFs. In certain preferred embodiments, there may also be a procedure to provide training materials, such as audio or video presentations, to be viewed by prospective participants. In certain preferred embodiments, the process also includes contacting subjects who have signed ICFs in the event that there is a change of circumstance which the subject may deem material to whether s/he would continue to consent, or whether the participant needs to provide a different type of consent to participate in particular event or trial.

Abstract: The systems and methods provide a dynamic process for obtaining and managing informed consent documentation. In general, the dynamic informed consent process (DICP) makes use of an intermediary organization, e.g., a trusted intermediary, which: (a) provides ICFs which have been dynamically generated for a specified trial or medical procedure and based on particular state or federal requirements, if any; and (b) archives copies of signed ICFs. In certain preferred embodiments, there may also be a procedure to provide training materials, such as audio or video presentations, to be viewed by prospective participants. In certain preferred embodiments, the process also includes contacting subjects who have signed ICFs in the event that there is a change of circumstance which the subject may deem material to whether s/he would continue to consent, or whether the participant needs to provide a different type of consent to participate in particular event or trial.

Abstract: Generally, the present invention provides a way of determining in an unsupervised manner additional members for a family that is defined initially through exemplar sequences. The present invention is unsupervised in that it proceeds without any information related to the exemplar sequences defining the family, without aligning the sequences, without prior knowledge of any patterns in the exemplar sequences, and without knowledge of the cardinality or characteristics of any features that may be present in the exemplar sequences. In one aspect of the invention, a method is used to take a set of unaligned sequences and discover several of many patterns common to some or all of the sequences. These patterns can then be used to determine if candidate sequences are members of the family.

Abstract: Generally, the present invention provides a way of determining in an unsupervised manner additional members for a family that is defined initially through exemplar sequences. The present invention is unsupervised in that it proceeds without any information related to the exemplar sequences defining the family, without aligning the sequences, without prior knowledge of any patterns in the exemplar sequences, and without knowledge of the cardinality or characteristics of any features that may be present in the exemplar sequences. In one aspect of the invention, a method is used to take a set of unaligned sequences and discover several or many patterns common to some or all of the sequences. These patterns can then be used to determine if candidate sequences are members of the family. In another aspect of the invention, a method is used to take a set of sequences and to determine a set of maximal patterns common to a number of sequences.

Abstract: The systems and methods provide a dynamic process for obtaining and managing informed consent documentation. In general, the dynamic informed consent process (DICP) makes use of an intermediary organization, e.g., a trusted intermediary, which: (a) provides ICFs which have been dynamically generated for a specified trial or medical procedure and based on particular state or federal requirements, if any; and (b) archives copies of signed ICFs. In certain preferred embodiments, there may also be a procedure to provide training materials, such as audio or video presentations, to be viewed by prospective participants. In certain preferred embodiments, the process also includes contacting subjects who have signed ICFs in the event that there is a change of circumstance which the subject may deem material to whether s/he would continue to consent, or whether the participant needs to provide a different type of consent to participate in particular event or trial.

Abstract: A pattern discovery-based method for identifying genetic associations in mapping complex traits. In one embodiment, this invention describes the applicable study designs, the pattern discovery algorithm on phenotypic/genotypic data, and methods to evaluate statistical significance of identified patterns. Patterns identified through the proposed methods act as signatures or profiles that can be used to locate genes or genomic regions responsible for the traits of interests in the genome. This invention has been successfully applied to two independent datasets collected from actual genetic studies and has produced significant results.

Abstract: The systems and methods provide a dynamic process for obtaining and managing informed consent documentation. In general, the dynamic informed consent process (DICP) makes use of an intermediary organization, e.g., a trusted intermediary, which: (a) provides ICFs which have been dynamically generated for a specified trial or medical procedure and based on particular state or federal requirements, if any; and (b) archives copies of signed ICFs. In certain preferred embodiments, there may also be a procedure to provide training materials, such as audio or video presentations, to be viewed by prospective participants. In certain preferred embodiments, the process also includes contacting subjects who have signed ICFs in the event that there is a change of circumstance which the subject may deem material to whether s/he would continue to consent, or whether the participant needs to provide a different type of consent to participate in particular event or trial.

Abstract: The method of the present invention discovers patterns in a protein sequences in two phases. In a sampling phase, preferably proper templates corresponding to a group of protein sequences are generated. Patterns corresponding to the templates are then generated and stored in memory. In a convolution phase, the patterns stored in memory are combined to identify a set of maximal patterns.

Abstract: The method of the present invention discovers patterns in a sequence of characters in two phases. In a sampling phase, preferably proper templates corresponding to the sequence of characters are generated. Patterns are then generated corresponding to the templates and stored in memory. In a convolution phase, the patterns stored in memory are combined to identify a set of maximal patterns.

Abstract: The present invention groups character sequences by identifying a sequence of characters. A set of internal repeats in said sequence of characters is identified by a pattern discovery technique. For at least one internal repeat belonging to the set of internal repeats, it is determined if the internal repeat corresponds to a group of character sequences; If so, first data that identifies the sequence of characters and second data that associates the sequence of characters with the group of character sequences is stored in persistent memory. The pattern discovery mechanism discovers patterns in a sequence of characters in two phases. In a sampling phase, preferably proper templates corresponding to the sequence of characters are generated. Patterns are then generated corresponding to the templates and stored in memory. In a convolution phase, the patterns stored in memory are combined to identify a set of maximal patterns.

Abstract: The method of the present invention discovers patterns in an sequence of characters in two phases. In a sampling phase, preferably proper templates corresponding to the sequence of characters are generated. Patterns are then generated corresponding to the templates and stored in memory. In a convolution phase, the patterns stored in memory are combined to identify a set of maximal patterns. A subset of the maximal patterns is selected. Compressed data representing the sequence of characters is generated. The compressed data includes first data data representing each selected pattern of the subset, and second data representing the sequence of characters wherein occurrences of each selected pattern within the sequence of characters is replaced by a reference to first data corresponding to the selected pattern. The method is useful in compressing information stored in a database or compressing information communicated over a communication link.