Patents by Inventor Aristotle G. Kalivretenos
Aristotle G. Kalivretenos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230103369Abstract: The present disclosure provides molecularly imprinted polymers (MIPs) for selectively binding one or more viruses of a target viral genus, for example SARS-CoV-2, as well as methods of manufacture and uses thereof.Type: ApplicationFiled: March 29, 2021Publication date: April 6, 2023Inventors: Jonathan P. GLUCKMAN, Sherman G. MCGILL, Aristotle G. KALIVRETENOS, Guneet KUMAR, Louis W. REICHEL, Brandi MAULL, Garrett KRAFT, Dae Jung KIM
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Publication number: 20120184683Abstract: Compounds linked to a solid support through a divalent linker moiety are disclosed. In particular, compounds such as 1-hydroxybenzotriazole-6-carboxylic acid are directly linked to the support under mild conditions (i.e., in aqueous or organic solvents at neutral pH and at room temperature). The polymer bound 1-hydroxybenzotriazole-6-carboxylic acid can be used for the derivatization of amines as well as for single step amino group modification of proteins, peptides, and amines via acylation or sulfonylation reactions. A flow through device and method for the single step amino group modifications of proteins, peptides, and amines is disclosed. Also disclosed is a flow through device for the detection of amines in a sample. Additionally, a device and method for the detection of amines in a sample using 1-hydroxybenzotriazole-6-carboxylic acid are disclosed. In a preferred embodiment, the device is used to detect the presence of amines in a spoiled meat product.Type: ApplicationFiled: January 20, 2012Publication date: July 19, 2012Applicant: The University of Maryland, Baltimore CountyInventor: Aristotle G. KALIVRETENOS
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Publication number: 20120184044Abstract: A molecularly-imprinted polymeric material that selectively binds with an explosive compound. The molecularly-imprinted polymeric material comprises a cross-linked, water-soluble polymer having basic functional groups and a binding site capable of selectively binding an explosive compound. The basic functional groups have a pKa that is sufficiently high to react with the explosive compound to result in a visually detectable color change. For example, the basic functional groups may have a pKa in the range of 6.0-9.0. The molecularly-imprinted polymeric material may be used in a variety of applications, such as a projectile for detecting explosives. Also described is a method for making a molecularly-imprinted polymeric material.Type: ApplicationFiled: December 30, 2009Publication date: July 19, 2012Applicant: RAPTOR DETECTION, INC.Inventors: Aristotle G. KALIVRETENOS, Kelly A. VAN HOUTEN, Jonathan P. GLUCKMAN, Frank M. HARDY, Igor P. DOROVSKOY, Robert TROWER
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Publication number: 20100255062Abstract: The present disclosure describes novel carbon-based diazeniumdiolates agents and compounds or salts or prodrugs thereof that release nitric oxide for the treatment of neuropathic gastrointestinal dysfunction. The neuropathic gastrointestinal dysfunction refers to disorders associated with motility, sensation and neuromuscular function that include but are not limited to conditions such as delayed gastric emptying.Type: ApplicationFiled: June 2, 2008Publication date: October 7, 2010Inventors: Aristotle G. Kalivretenos, Robert E. Raulli, Niaz Sahibzada, Richard Gillis, Mark S. Niedringhaus
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Publication number: 20100010167Abstract: Compounds linked to a solid support through a divalent linker moiety are disclosed. In particular, compounds such as 1-hydroxybenzotriazole-6-carboxylic acid are directly linked to the support under mild conditions (i.e., in aqueous or organic solvents at neutral pH and at room temperature). The polymer bound 1-hydroxybenzotriazole-6-carboxylic acid can be used for the derivatization of amines as well as for single step amino group modification of proteins, peptides, and amines via acylation or sulfonylation reactions. A flow through device and method for the single step amino group modifications of proteins, peptides, and amines is disclosed. Also disclosed is a flow through device for the detection of amines in a sample. Additionally, a device and method for the detection of amines in a sample using 1-hydroxybenzotriazole-6-carboxylic acid are disclosed. In a preferred embodiment, the device is used to detect the presence of amines in a spoiled meat product.Type: ApplicationFiled: September 21, 2009Publication date: January 14, 2010Applicant: THE UNIVERSITY OF MARYLAND, BALTIMORE COUNTYInventor: Aristotle G. Kalivretenos
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Patent number: 7592183Abstract: Compounds linked to a solid support through a divalent linker moiety are disclosed. In particular, compounds such as 1-hydroxybenzotriazole-6-carboxylic acid are directly linked to the support under mild conditions (i.e., in aqueous or organic solvents at neutral pH and at room temperature). The polymer bound 1-hydroxybenzotriazole-6-carboxylic acid can be used for the derivatization of amines as well as for single step amino group modification of proteins, peptides, and amines via acylation or sulfonylation reactions. A flow through device and method for the single step amino group modifications of proteins, peptides, and amines is disclosed. Also disclosed is a flow through device for the detection of amines in a sample. Additionally, a device and method for the detection of amines in a sample using 1-hydroxybenzotriazole-6-carboxylic acid are disclosed. In a preferred embodiment, the device is used to detect the presence of amines in a spoiled meat product.Type: GrantFiled: October 25, 2002Date of Patent: September 22, 2009Assignee: The University of Maryland, Baltimore CountyInventor: Aristotle G. Kalivretenos
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Patent number: 7229835Abstract: A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: is disclosed. In particular, the 1-hydroxybenzotriazole-6-carboxylic acid is directly linked to the support under mild conditions (i.e., in aqueous or organic solvents at neutral pH and at room temperature). The polymer bound 1-hydroxybenzotriazole-6-carboxylic acid can be used for the derivatization of amines as well as for single step amino group modification of proteins, peptides, and amines via acylation or sulfonylation reactions. A flow through device and method for the single step amino group modifications of proteins, peptides, and amines is disclosed. Also disclosed is a flow through device for the detection of amines in a sample. Additionally, a device and method for the detection of amines in a sample using 1-hydroxybenzotriazole-6-carboxylic acid is disclosed. In a preferred embodiment, the device is used to detect the presence of amines in a spoiled meat product.Type: GrantFiled: October 25, 2001Date of Patent: June 12, 2007Assignee: The University of Maryland, Baltimore CountyInventor: Aristotle G. Kalivretenos
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Patent number: 7078554Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.Type: GrantFiled: October 4, 2004Date of Patent: July 18, 2006Assignee: Sensors for Medicine and Science, Inc.Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik
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Patent number: 6800451Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.Type: GrantFiled: July 3, 2002Date of Patent: October 5, 2004Assignee: Sensors for Medicine and Science, Inc.Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik
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Publication number: 20030104609Abstract: A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: 1Type: ApplicationFiled: October 25, 2001Publication date: June 5, 2003Inventor: Aristotle G. Kalivretenos
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Publication number: 20030082663Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.Type: ApplicationFiled: July 3, 2002Publication date: May 1, 2003Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik
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Publication number: 20020127626Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.Type: ApplicationFiled: December 28, 2001Publication date: September 12, 2002Applicant: Sensors for Medicine and Science, Inc.Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik
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Publication number: 20020119581Abstract: Disclosed are methods for detecting analytes with indicator systems which may undergo a molecular configurational change upon exposure to the analyte. The configurational change affects a detectable quality associated with the indicator system, thereby allowing detection of the presence or concentration of the analyte.Type: ApplicationFiled: December 28, 2001Publication date: August 29, 2002Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik, Edwin F. Ullman
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Publication number: 20020094586Abstract: Disclosed are methods for detecting analytes with indicator systems which may undergo a molecular configurational change upon exposure to the analyte. The configurational change affects a detectable quality associated with the indicator system, thereby allowing detection of the presence or concentration of the analyte.Type: ApplicationFiled: January 5, 2001Publication date: July 18, 2002Applicant: Sensors for Medicine and Science, Inc.Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik, Edwin F. Ullman
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Publication number: 20020090734Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.Type: ApplicationFiled: January 5, 2001Publication date: July 11, 2002Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik