Abstract: A contact lens (301) and methods of manufacturing such a lens (301) are described. The lens (301) includes an optic zone (302). The optic zone (302) comprises a central region (305), the central region (305) having a first optical axis, a centre of curvature that is on the first optical axis, and a diameter that is less than 2.0 mm. The optic zone (302) comprises an annular region (303). The annular region (303) comprises a plurality of concentric treatment zones (303a, 303b), wherein each treatment zone (303a, 303b) has a radial sagittal power profile that increases with increasing radial distance from the optical axis.

Abstract: A WS12-releasing contact lens is described as well as method of manufacturing the same. The WS12-releasing contact lens comprises a polymeric lens body and WS12 releasably adhered to the polymeric lens body, and releases from 0.05 ?g to 0.5 ?g WS12 after 1 hour in a release media or when worn by a human subject. The WS12-releasing contact lens can be comfortably worn by a symptomatic contact lens wearer and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events and/or reduce contact lens dryness in a symptomatic contact lens wearer.

Abstract: A WS12-releasing contact lens is described as well as method of manufacturing the same. The WS12-releasing contact lens comprises a polymeric lens body and WS12 releasably adhered to the polymeric lens body, and releases from 0.05 ?g to 0.5 ?g WS12 after 1 hour in a release media or when worn by a human subject. The WS12-releasing contact lens can be comfortably worn by a symptomatic contact lens wearer and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events and/or reduce contact lens dryness in a symptomatic contact lens wearer.

Abstract: Methods of manufacturing an ophthalmic lens are described. The methods include a step of providing an ophthalmic lens; and a step of providing a photocurable film. The methods use a digital light projections system to photocure at least one region of the film to produce at least one photocured gradient index refractive element. The film is applied to a surface of the lens.

Abstract: A contact lens (101), the lens (101) including an optic zone (102). The optic zone (102) comprises a central region (105), the central region (105) having a centre of curvature that is on an optical axis (119). The optic zone (102) comprises a first annular region (103). The first annular region (103) has an off-axis centre of curvature that is a first distance from the optical axis (119). The first annular region (103) has a sagittal power profile that increases with increasing radial distance from the optical axis (119) with a gradient of between 1.0 D/mm and 20.0 D/mm. At a point halfway across the width of the first annular region (103), the sagittal power matches the average radial sagittal power of the central region (105).

Abstract: An ophthalmic lens (112?, 200) for use in preventing or slowing the development or progression of myopia comprises an optic zone (202) for focusing light from distant point objects to a focal surface. The optic zone comprises a diffractive lens (206) for manipulating the longitudinal chromatic aberration properties of the light proximate the focal surface.

Abstract: A contact lens (201) includes an optic zone (202) that is centred on an optical axis (219), and a peripheral zone (204) surrounds the optic zone (202). A cross-sectional slice through the optic zone (202) along a meridian comprises a series of successive arcs (203a-203h) having a radial curvature power profile. The radial curvature power profile increases monotonically with radial distance from the optical axis (219). Light rays from a distant point source passing through the midpoint of each arc converge toward a point (215) on the first optical axis (203a-203h). For each arc (203a-203h), light rays from a distant point source pass through that arc (203a-203h) and converge towards a point (216) that is spaced away from the optical axis by a first distance. Methods of designing and manufacturing such contact lenses (201) are also described.

Abstract: A contact lens (201) and methods of manufacturing such a lens are described. The lens (201) includes an optic zone (202). The optic zone (202) comprises a central region (205), the central region (205) having a first optical axis (219), a base radial curvature power, a base radial sagittal power, and a centre of curvature that is on the first optical axis (219). The optic zone (202) comprises an annular region (203), wherein at a point halfway across the width of the annular region (203) the annular region (203) has a radial curvature power of X, wherein X is greater than the base radial curvature power. The annular region (203) has an off-axis centre of curvature that is a first distance from the optical axis (219) such that, at a point halfway across its width, the annular region (203) has a sagittal power of Y, wherein Y is greater than the base radial sagittal power, and wherein Y is less than X.

Abstract: An ophthalmic lens for use in preventing or slowing the development or progression of myopia. The lens has a first optical axis. A first surface of the lens is shaped to form a first surface power map. A second surface of the lens is shaped to form a second surface power map. The first and second surface power maps together form a lens power map. One of the first surface power map, the second surface power map, and the lens power map comprises: a base region and a myopia control region. The base region has a base power which focusses light to a focal point that is on the first optical axis. The myopia control region comprises a spiral shape and focusses light to a plurality of focal points that are offset from the first optical axis. Also a method of manufacturing such an ophthalmic lens.

Abstract: Methods of manufacturing an ophthalmic lens are described. The methods include a step of providing an ophthalmic lens; and a step of providing a photocurable film. The methods use a digital light projections system to photocure at least one region of the film to produce at least one photocured gradient index refractive element. The film is applied to a surface of the lens.

Abstract: A contact lens that is configured to rotate when the lens is being worn by a lens wearer, methods of manufacturing such a lens, and methods of using such a lens to provide a rotationally varying treatment to a lens wearer are described. The lens includes an optic zone and a peripheral zone surrounding the optic zone. The peripheral zone has a variation in thickness configured to promote rotation of the lens.

Abstract: Ophthalmic lenses are described that have a layer, which has a base refractive index, provided on a surface of the lens. The layer includes at least one gradient index optical element. The ophthalmic lens may be a spectacle lens or a contact lens.

Abstract: A film for applying to an ophthalmic lens is described. The film, or the combination of the film and the ophthalmic lens are designed to prevent or slow the development or progression of myopia. The film has a base refractive index and includes at least one gradient index optical element. Ophthalmic lenses, such as spectacle lenses and contact lenses, that include the films are also described.

Abstract: Methods for reducing progression of myopia are described. These methods may be understood to be myopia control methods. The methods include a step of providing at least one contact lens having an optic zone and a peripheral zone surrounding the optic zone. The optic zone includes a central region and an annular region that surrounds the central region. The annular region includes a treatment portion that is not rotationally symmetric about an axis of the lens. And, the methods include a step of rotating about the axis, over time, the treatment portion of the at least one contact lens on the eye, wherein the rotation reduces adaptation to a treatment stimulus by the person over time.

Abstract: A contact lens for use in preventing or slowing the development or progression of myopia, and methods of manufacturing and using such a lens. The optic zone of the lens comprises a central region having a curvature providing a base power. The optic zone comprises an annular region circumferentially surrounding the central region. The annular region comprises a treatment zone having a characteristic that reduces the contrast of an image of an object that is formed by light passing through the central region and the treatment zone compared to an image of an object that would be formed by light passing through only the central region. The characteristic that causes the contrast reduction varies with meridian around the annular region. A peripheral zone surrounding the annular region has a constant thickness profile in every meridian or a variation in thickness configured to promote rotation of the lens.

Abstract: A contact lens for use in preventing or slowing the development or progression of myopia, and methods of manufacturing and using such a lens. The lens includes an optic zone and a peripheral zone that has a variation in thickness configured to control rotation of the lens. The optic zone comprises a central region having a base power that focuses light from distant point objects to a distal focal surface, said light forming a blur circle as it passes through a proximal focal surface. An annular region surrounding the central region, includes an add power region spanning less than 75% of the annular region, and having an add power of 0.5 D or more. Points defining centres of curvature of the add power region form a segment of an annulus. The add power region focuses light from distant point objects to form a focused arc at a proximal focal surface.

Abstract: A WS12-releasing contact lens is described as well as method of manufacturing the same. The WS12-releasing contact lens comprises a polymeric lens body and WS12 releasably adhered to the polymeric lens body, and releases from 0.05 ?g to 0.5 ?g WS12 after 1 hour in a release media or when worn by a human subject. The WS12-releasing contact lens can be comfortably worn by a symptomatic contact lens wearer and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events and/or reduce contact lens dryness in a symptomatic contact lens wearer.

Abstract: A set of contact lenses for use in preventing or slowing the development or progression of myopia, methods of manufacturing and using such lenses. Each lens includes an optic zone and a surrounding peripheral zone that has a varying thickness profile that is configured to control rotation of the lens. The optic zone comprises a central region having a curvature providing a base power. An annular region circumferentially surrounds the central region and comprises a treatment zone having a characteristic that reduces the contrast of an image that is formed by light passing through the central region and the treatment zone compared to an image of an object that would be formed by light passing through only the central region. The treatment zone is rotationally positioned, relative to the peripheral zone thickness profile, at a different angle about the optic axis in each lens in the set of lenses.

Abstract: The present invention is related to topical ophthalmic compositions comprising brimonidine. Also described herein are methods for the treatment of ocular conditions (e.g., presbyopia), methods for improving near reading speed in a subject with presbyopia, methods for improving near vision in a subject with presbyopia, and methods for reducing pupil diameter in a subject with presbyopia using the topical ophthalmic compositions.

Abstract: A contact lens for use in preventing or slowing the development or progression of myopia, and methods relating thereto, are described. The lens includes an optic zone comprising a central region having a first optical axis, and a curvature providing a base power, and centred on a centre of curvature that is on the first optical axis. The optic zone comprises an annular region, wherein the annular region surrounds the central region. The annular region comprises at least one maximum add power meridian having a curvature providing a maximum add power, and centred on a centre of curvature that is a first distance from the first optical axis. The annular region comprises at least one intermediate add power meridian, having a curvature providing an intermediate add power of between zero dioptres of add power and the maximum add power, and centred on a centre of curvature that is a different distance from the optical axis than the first distance.