Patents by Inventor Arthur E. Colvin, Jr.

Arthur E. Colvin, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190352510
    Abstract: The invention relates to a porphyrin time domain indicator. The indicator may be used for detection of a particular analyte in vivo or in vitro. The indicator may be used for detection of glucose in vivo or in vitro.
    Type: Application
    Filed: June 16, 2017
    Publication date: November 21, 2019
    Applicant: Profusa, Inc.
    Inventor: Arthur E. COLVIN, JR.
  • Publication number: 20190069804
    Abstract: Systems and methods for automatically triggering wireless power and data exchange between an external reader and an implanted sensor. The implanted sensor may measure the strength of an electrodynamic field received wirelessly from the reader and convey field strength data based on the measured strength of the received electrodynamic field to the reader. If the field strength data indicates that the strength of an electrodynamic field received by the sensor is sufficient for the implanted sensor to perform an analyte measurement, the reader may convey an analyte measurement command to the sensor, which may execute the analyte measurement command and convey measurement information back to the reader. The systems and methods may trigger the analyte measurement as the reader transiently passes within sufficient range/proximity to the implant (or vice versa).
    Type: Application
    Filed: July 30, 2018
    Publication date: March 7, 2019
    Applicant: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, JR., Andrew DeHennis
  • Patent number: 10034619
    Abstract: Systems and methods for automatically triggering wireless power and data exchange between an external reader and an implanted sensor. The implanted sensor may measure the strength of an electrodynamic field received wirelessly from the reader and convey field strength data based on the measured strength of the received electrodynamic field to the reader. If the field strength data indicates that the strength of an electrodynamic field received by the sensor is sufficient for the implanted sensor to perform an analyte measurement, the reader may convey an analyte measurement command to the sensor, which may execute the analyte measurement command and convey measurement information back to the reader. The systems and methods may trigger the analyte measurement as the reader transiently passes within sufficient range/proximity to the implant (or vice versa).
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: July 31, 2018
    Assignee: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, Jr., Andrew DeHennis
  • Publication number: 20180146885
    Abstract: An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.
    Type: Application
    Filed: June 15, 2017
    Publication date: May 31, 2018
    Applicant: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, JR., Hui Jiang
  • Publication number: 20170202517
    Abstract: An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.
    Type: Application
    Filed: February 3, 2017
    Publication date: July 20, 2017
    Applicant: Senseonics, Incorporated
    Inventors: Arthur E. COLVIN, JR., Hui JIANG
  • Patent number: 9693714
    Abstract: The present invention relates to an optical sensor that may be implanted within a living animal (e.g., a human) and may be used to measure the concentration of an analyte in a medium within the animal. The optical sensor may wirelessly receive and may be capable of bi-directional data communication. The optical sensor may include a semiconductor substrate in which various circuit components, one or more photodectors and/or a light source may be fabricated. The circuit components fabricated in the semiconductor substrate may include a comparator, an analog to digital converter, a temperature transducer, a measurement controller, a rectifier and/or a nonvolatile storage medium. The comparator may output a signal indicative of the difference between the outputs of first and second photodetectors. The measurement controller may receive digitized temperature, photodetector and/or comparator measurements and generate measurement information, which may be wirelessly transmitted from the optical sensor.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: July 4, 2017
    Assignee: Senseonics, Incorporated
    Inventors: Andrew DeHennis, Arthur E. Colvin, Jr.
  • Patent number: 9681824
    Abstract: An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: June 20, 2017
    Assignee: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, Jr., Hui Jiang
  • Publication number: 20170150901
    Abstract: Systems and methods for automatically triggering wireless power and data exchange between an external reader and an implanted sensor. The implanted sensor may measure the strength of an electrodynamic field received wirelessly from the reader and convey field strength data based on the measured strength of the received electrodynamic field to the reader. If the field strength data indicates that the strength of an electrodynamic field received by the sensor is sufficient for the implanted sensor to perform an analyte measurement, the reader may convey an analyte measurement command to the sensor, which may execute the analyte measurement command and convey measurement information back to the reader. The systems and methods may trigger the analyte measurement as the reader transiently passes within sufficient range/proximity to the implant (or vice versa).
    Type: Application
    Filed: February 10, 2017
    Publication date: June 1, 2017
    Applicant: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, Jr., Andrew DeHennis
  • Publication number: 20170119288
    Abstract: The present invention relates to an optical sensor that may be implanted within a living animal (e.g., a human) and may be used to measure the concentration of an analyte in a medium within the animal. The optical sensor may wirelessly receive and may be capable of bi-directional data communication. The optical sensor may include a semiconductor substrate in which various circuit components, one or more photodectors and/or a light source may be fabricated. The circuit components fabricated in the semiconductor substrate may include a comparator, an analog to digital converter, a temperature transducer, a measurement controller, a rectifier and/or a nonvolatile storage medium. The comparator may output a signal indicative of the difference between the outputs of first and second photodetectors. The measurement controller may receive digitized temperature, photodetector and/or comparator measurements and generate measurement information, which may be wirelessly transmitted from the optical sensor.
    Type: Application
    Filed: January 11, 2017
    Publication date: May 4, 2017
    Applicant: Senseonics, Incorporated
    Inventors: Andrew DeHennis, Arthur E. Colvin, JR.
  • Publication number: 20160374556
    Abstract: Some embodiments described herein relate to a reader having a distributed source of radiation and a photodetector. The photodetector can be operable to sense radiation (e.g., light) emitted by an implanted sensor. The distributed source of radiation can at least partially surrounds the photodetector. The distributed source of radiation generates a photon cloud of excitation radiation within the skin, which can substantially envelopes a sensor that is implanted within the skin at a depth that is on the order of a centimeter or less.
    Type: Application
    Filed: June 27, 2016
    Publication date: December 29, 2016
    Inventors: Arthur E. COLVIN, JR., William A. MCMILLAN, Steven PULLINS
  • Patent number: 9414775
    Abstract: Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: August 16, 2016
    Assignee: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, Jr., Xiaolin Wang, Colleen Mdingi, Andrew DeHennis
  • Patent number: 9377351
    Abstract: Apparatuses and methods for limiting the angle of incidence (AOI) of light reaching a dichroic filter. The apparatus may include an AOI filter element and the dichroic filter. The apparatus may be a sensor and may include a photodetector. The dichroic filter may be configured to prevent light having a wavelength outside a band pass region from reaching the photodetector and to pass light having a wavelength within the band pass. Physical limitations of the dichroic filter may preclude the dichroic filter from preventing high AOI light having a wavelength outside a band pass region from reaching the photodetector. The AOI filter element may be configured to prevent light having a high AOI from reaching the dichroic band pass filter and to propagate light having a low AOI to the dichroic band pass filter. The AOI filter element may be a fiber optic bundle comprising a plurality of optical fibers.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: June 28, 2016
    Assignee: Senseonics, Incorporated
    Inventor: Arthur E. Colvin, Jr.
  • Patent number: 9345426
    Abstract: Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: May 24, 2016
    Assignee: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, Jr., Xiaolin Wang, Colleen Mdingi, Andrew DeHennis
  • Publication number: 20150330828
    Abstract: A fuel-gauge system detects the angular position of a float-based fluid-level-detecting mechanism's magnet and determines the level of liquid fuel remaining within a cylinder. The system wirelessly transmits to an app or application running on a multipurpose, consumer computing device fuel-remaining information, either in terms of percentage of maximum fluid level or, preferably, in terms of actual fluid volume remaining. The system determines fluid temperature and compensates for variation in the fluid-level attributable to temperature fluctuation.
    Type: Application
    Filed: May 15, 2015
    Publication date: November 19, 2015
    Inventor: Arthur E. Colvin, JR.
  • Publication number: 20140088383
    Abstract: An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.
    Type: Application
    Filed: September 11, 2013
    Publication date: March 27, 2014
    Applicant: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, JR., Hui Jiang
  • Patent number: 8648356
    Abstract: A light emitting diode for harsh environments includes a substantially transparent substrate, a semiconductor layer deposited on a bottom surface of the substrate, several bonding pads, coupled to the semiconductor layer, formed on the bottom surface of the substrate, and a micro post, formed on each bonding pad, for electrically connecting the light emitting diode to a printed circuit board. An underfill layer may be provided between the bottom surface of the substrate and the top surface of the printed circuit board, to reduce water infiltration under the light emitting diode substrate. Additionally, a diffuser may be mounted to a top surface of the light emitting diode substrate to diffuse the light emitted through the top surface.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: February 11, 2014
    Assignee: Senseonics, Incorporated
    Inventors: Jason D. Colvin, Arthur E. Colvin, Jr., Andrew DeHennis, Jody L. Krsmanovic
  • Publication number: 20140018644
    Abstract: Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing.
    Type: Application
    Filed: July 9, 2013
    Publication date: January 16, 2014
    Applicant: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, JR., Xiaolin Wang, Colleen Mdingi, Andrew DeHennis
  • Publication number: 20130328089
    Abstract: A light emitting diode for harsh environments includes a substantially transparent substrate, a semiconductor layer deposited on a bottom surface of the substrate, several bonding pads, coupled to the semiconductor layer, formed on the bottom surface of the substrate, and a micro post, formed on each bonding pad, for electrically connecting the light emitting diode to a printed circuit board. An underfill layer may be provided between the bottom surface of the substrate and the top surface of the printed circuit board, to reduce water infiltration under the light emitting diode substrate. Additionally, a diffuser may be mounted to a top surface of the light emitting diode substrate to diffuse the light emitted through the top surface.
    Type: Application
    Filed: April 8, 2013
    Publication date: December 12, 2013
    Applicant: Senseonics, Incorporated
    Inventors: Jason D. COLVIN, Arthur E. Colvin, JR., Andrew DeHennis, Jody L. Krsmanovic
  • Publication number: 20130324819
    Abstract: Apparatuses and methods for limiting the angle of incidence (AOI) of light reaching a dichroic filter. The apparatus may include an AOI filter element and the dichroic filter. The apparatus may be a sensor and may include a photodetector. The dichroic filter may be configured to prevent light having a wavelength outside a band pass region from reaching the photodetector and to pass light having a wavelength within the band pass. Physical limitations of the dichroic filter may preclude the dichroic filter from preventing high AOI light having a wavelength outside a band pass region from reaching the photodetector. The AOI filter element may be configured to prevent light having a high AOI from reaching the dichroic band pass filter and to propagate light having a low AOI to the dichroic band pass filter. The AOI filter element may be a fiber optic bundle comprising a plurality of optical fibers.
    Type: Application
    Filed: April 24, 2013
    Publication date: December 5, 2013
    Applicant: Senseonics, Incorporated
    Inventor: Arthur E. Colvin, JR.
  • Publication number: 20130241745
    Abstract: Systems and methods for automatically triggering wireless power and data exchange between an external reader and an implanted sensor. The implanted sensor may measure the strength of an electrodynamic field received wirelessly from the reader and convey field strength data based on the measured strength of the received electrodynamic field to the reader. If the field strength data indicates that the strength of an electrodynamic field received by the sensor is sufficient for the implanted sensor to perform an analyte measurement, the reader may convey an analyte measurement command to the sensor, which may execute the analyte measurement command and convey measurement information back to the reader. The systems and methods may trigger the analyte measurement as the reader transiently passes within sufficient range/proximity to the implant (or vice versa).
    Type: Application
    Filed: October 11, 2012
    Publication date: September 19, 2013
    Applicant: Senseonics, Incorporated
    Inventors: Arthur E. Colvin, JR., Andrew Dehennis