Patents by Inventor Arthur E. Colvin
Arthur E. Colvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7822450Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.Type: GrantFiled: December 10, 2007Date of Patent: October 26, 2010Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Casey J. O'Connor, Andrew D. DeHennis
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Patent number: 7800078Abstract: A printed circuit device used in conjunction with inductive power and data transmission applications is formed substantially of ferrite material, with an inductive coil conductor formed around the substrate to increase the electromagnetic properties of the coil for both power and data transmission functions, thereby eliminating the need for a discrete ferrite core wire-wound coil to be connected to the circuit device.Type: GrantFiled: April 15, 2004Date of Patent: September 21, 2010Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., John S. Gerig, Paul Samuel Zerwekh, Jeffrey C. Lesho, Benjamin N. McLeod
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Patent number: 7755022Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: GrantFiled: July 28, 2008Date of Patent: July 13, 2010Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Paul Samuel Zerwekh, Jeffrey C. Lesho, Robert W. Lynn, Carrie R. Lorenz, Casey J. O'Connor, Steven J. Walters
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Patent number: 7713745Abstract: The invention relates to immobilization methods, in particular for immobilizing indicator molecules on supports such as sensors and to sensors having those molecules immobilized to their surface. Non-covalent immobilization of macromolecular indicator molecules on those supports via mechanical interlacing with polymers at the surface of a support and via ionic bonding via charged moieties of indicator molecules and ionic groups on the surface of the support are disclosed.Type: GrantFiled: April 13, 2004Date of Patent: May 11, 2010Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Carrie R. Lorenz
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Publication number: 20100073669Abstract: The present invention provides systems and methods for measuring an analyte in a medium without exposing the medium to contamination. The systems and methods employ a novel combination of a small sensor device embedded in a Luer cap and capable of wirelessly transmitting data to a reading device.Type: ApplicationFiled: September 21, 2009Publication date: March 25, 2010Applicant: Sensors for Medicine & Science, Inc.Inventors: Arthur E. COLVIN, JR., Casey J. O'Connor, Daniel C. Ferraro
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Publication number: 20100024526Abstract: A method and sensor for measuring the concentration of an analyte about radiantly excitable indicator molecules. A stimulus waveform is used to drive a radiant source. The indicator molecules are exposed to the radiant source. A response waveform is generated to represent photoluminescent radiation emitted by the indicator molecules. A phase difference between the stimulus waveform and the response waveform is a function of the concentration of the analyte that enables determining the analyte concentration.Type: ApplicationFiled: July 24, 2009Publication date: February 4, 2010Applicant: Sensors for Medicine & Science, Inc.Inventors: Arthur E. Colvin, JR., Andrew DeHennis
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Publication number: 20080218759Abstract: A light emitting diode for harsh environments includes a substantially transparent substrate, a semiconductor layer deposited on a bottom surface of the substrate, several bonding pads, coupled to the semiconductor layer, formed on the bottom surface of the substrate, and a micro post, formed on each bonding pad, for electrically connecting the light emitting diode to a printed circuit board. An underfill layer may be provided between the bottom surface of the substrate and the top surface of the printed circuit board, to reduce water infiltration under the light emitting diode substrate. Additionally, a diffuser may be mounted to a top surface of the light emitting diode substrate to diffuse the light emitted through the top surface.Type: ApplicationFiled: March 6, 2008Publication date: September 11, 2008Applicant: SENSORS FOR MEDICINE AND SCIENCE, INC.Inventors: Jason D. Colvin, Arthur E. Colvin, Andrew DeHennis, Jody L. Krsmanovic
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Patent number: 7405387Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: GrantFiled: December 28, 2006Date of Patent: July 29, 2008Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Paul Samuel Zerwekh, Jeffrey C. Lesho, Robert William Lynn, Carrie R. Lorenz, Casey J. O'Connor, Steven J. Walters
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Publication number: 20080145944Abstract: Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups.Type: ApplicationFiled: November 30, 2007Publication date: June 19, 2008Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Mark Alan Mortellaro, Aneta Modzelewska
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Publication number: 20080139904Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.Type: ApplicationFiled: December 10, 2007Publication date: June 12, 2008Applicant: SENSORS FOR MEDICINE AND SCIENCE, INC.Inventors: Arthur E. Colvin, Casey J. O'Connor, Andrew D. DeHennis
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Patent number: 7308292Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.Type: GrantFiled: April 15, 2005Date of Patent: December 11, 2007Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Casey J. O'Connor, Andrew D. DeHennis
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Patent number: 7289836Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body.Type: GrantFiled: January 27, 2006Date of Patent: October 30, 2007Assignee: Sensors for Medicine and Science, Inc.Inventor: Arthur E. Colvin, Jr.
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Patent number: 7227156Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: GrantFiled: October 21, 2005Date of Patent: June 5, 2007Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Paul Samuel Zerwekh, Jeffrey C. Lesho, Robert William Lynn, Carrie R. Lorenz, Casey J. O'Connor, Steven J. Walters
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Patent number: 7190445Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.Type: GrantFiled: June 24, 2005Date of Patent: March 13, 2007Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Steven J. Walters
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Patent number: 7135342Abstract: An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions.Type: GrantFiled: May 3, 2002Date of Patent: November 14, 2006Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Robert W. Lynn
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Patent number: 7060503Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.Type: GrantFiled: March 1, 2004Date of Patent: June 13, 2006Assignee: Sensors for Medicine and Science, Inc.Inventor: Arthur E. Colvin, Jr.
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Patent number: 7016714Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body.Type: GrantFiled: February 24, 2004Date of Patent: March 21, 2006Assignee: Sensors for Medicine and ScienceInventor: Arthur E. Colvin, Jr.
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Patent number: 6940590Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.Type: GrantFiled: December 11, 2002Date of Patent: September 6, 2005Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Steven J. Walters
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Publication number: 20040229370Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.Type: ApplicationFiled: March 1, 2004Publication date: November 18, 2004Applicant: Sensors for Medicine and Science, Inc.Inventor: Arthur E. Colvin
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Publication number: 20040206916Abstract: A printed circuit device used in conjunction with inductive power and data transmission applications is formed substantially of ferrite material, with an inductive coil conductor formed around the substrate to increase the electromagnetic properties of the coil for both power and data transmission functions, thereby eliminating the need for a discrete ferrite core wire-wound coil to be connected to the circuit device.Type: ApplicationFiled: April 15, 2004Publication date: October 21, 2004Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, John S. Gerig, Paul Samel Zerwekh, Jeffery C. Lesho, Benjamin N. McLeod