Patents by Inventor Arul Chinnaiyan

Arul Chinnaiyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PREVENTING OR TREATING CONDITIONS RELATED TO PIKFYVE ACTIVITY
    Publication number: 20230364084
    Abstract: Provided herein are compositions and methods for preventing, attenuating or treating disorders characterized with characterized with PIKfyve-expressing cells. In particular, provided herein are methods for preventing, attenuating or treating disorders characterized with PIKfyve-expressing cells through use of compositions comprising a therapeutic agent capable of inhibiting PIKfyve activity.
    Type: Application
    Filed: October 28, 2021
    Publication date: November 16, 2023
    Inventors: Yuanyuan Qiao, Arul Chinnaiyan
  • Compositions and methods for treating cancer
    Patent number: 11746151
    Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of targeted therapy to treat cancer (e.g., prostate cancer) in subjects with CDK12 mutations.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: September 5, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Arul Chinnaiyan, Dan Robinson, Yi-Mi Wu, Marcin Cieslik
  • ncRNA AND USES THEREOF
    Publication number: 20230016456
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.
    Type: Application
    Filed: July 18, 2022
    Publication date: January 19, 2023
    Inventors: Arul Chinnaiyan, John Prensner, Matthew Iyer
  • ncRNA and uses thereof
    Patent number: 11390923
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: July 19, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, John Prensner, Matthew Iyer
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20210155695
    Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of targeted therapy to treat cancer (e.g., prostate cancer) in subjects with CDK12 mutations.
    Type: Application
    Filed: April 12, 2019
    Publication date: May 27, 2021
    Inventors: Arul CHINNAIYAN, Dan ROBINSON, Yi-Mi WU, Marcin CIESLIK
  • Compositions and methods for treating cancer
    Patent number: 11013754
    Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of ARlnc1 for treating cancer.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: May 25, 2021
    Assignee: The Regents of the University of Michigan
    Inventors: Arul Chinnaiyan, Rohit Malik, Yajia Zhang, Marcin Cieslik, Sethuramasundaram Pitchiaya
  • RAF gene fusions
    Patent number: 11015224
    Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: May 25, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
  • Non-coding RNAS and uses thereof
    Patent number: 10889864
    Abstract: Provided herein are compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, provided herein are non-coding RNAs as diagnostic markers and clinical targets for cancer.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: January 12, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, Felix Y. Feng, John Prensner, Matthew Iyer, Yashar Niknafs
  • Compositions and methods for treating cancer
    Patent number: 10815484
    Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of THOR for treating cancer.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: October 27, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, Yasuyuki Hosono
  • ERG targeted therapy
    Patent number: 10774122
    Abstract: The present disclosure relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present disclosure relates to recurrent gene fusions as clinical targets for cancer.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: September 15, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, Xiaoju Wang
  • ncRNA AND USES THEREOF
    Publication number: 20200224276
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.
    Type: Application
    Filed: July 26, 2019
    Publication date: July 16, 2020
    Inventors: Arul Chinnaiyan, John Prensner, Matthew Iyer
  • ncRNA AND USES THEREOF
    Publication number: 20200165682
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.
    Type: Application
    Filed: June 26, 2019
    Publication date: May 28, 2020
    Inventors: Arul Chinnaiyan, John Prensner, Matthew Iyer
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20190307787
    Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of ARlnc1 for treating cancer.
    Type: Application
    Filed: April 9, 2019
    Publication date: October 10, 2019
    Inventors: Arul Chinnaiyan, Rohit Malik, Yajia Zhang, Marcin Cieslik, Sethuramasundaram Pitchiaya
  • Schlap-1 ncRNA and uses thereof
    Patent number: 10407735
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ncRNAs as diagnostic markers and clinical targets for prostate, lung, breast and pancreatic cancer.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: September 10, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, John Prensner, Matthew Iyer
  • BET bromodomain inhibitors and therapeutic methods using the same
    Patent number: 10391175
    Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: August 27, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Xu Ran, Yujun Zhao, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachern, Jeanne Stuckey, Jennifer Lynn Meagher, Duxin Sun, Xiaoqin Li, Bing Zhou, Hacer Karatas, Ruijuan Luo, Arul Chinnaiyan, Irfan A. Asangani
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20190153449
    Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of THOR for treating cancer.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 23, 2019
    Inventors: Arul Chinnaiyan, Yasuyuki Hosono
  • 9H-pyrimido [4,5-b]indoles and related analogs as BET bromodomain inhibitors
    Patent number: 10253044
    Abstract: The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Yujun Zhao, Bing Zhou, Angelo Aguilar, Liu Liu, Longchuan Bai, Donna McEachern, Duxin Sun, Bo Wen, Ruijuan Luo, Ting Zhao, Arul Chinnaiyan, Irfan A. Asangani, Jeanne Stuckey, Jennifer Lynn Meagher, Xu Ran, Yang Hu
  • Recurrent gene fusions in prostate cancer
    Patent number: 10190173
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: January 29, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • ERG TARGETED THERAPY
    Publication number: 20180273595
    Abstract: The present disclosure relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present disclosure relates to recurrent gene fusions as clinical targets for cancer.
    Type: Application
    Filed: March 19, 2018
    Publication date: September 27, 2018
    Inventors: Arul Chinnaiyan, Xiaoju Wang
  • Recurrent gene fusions in cancer
    Patent number: 9783853
    Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for cancer.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: October 10, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, Yi-Mi Wu, Dan Robinson