Patents by Inventor Atanas G. Georgiev

Atanas G. Georgiev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing 2-(phenylamino)-imidazolines-(2)
    Patent number: 4290971
    Abstract: A process for preparing compounds of the formula: ##STR1## or pharmaceutically acceptable salts thereof, wherein R.sub.1 and R.sub.2 each individually are hydrogen, halogen, or nitro, which comprises the steps of: (a) alkylating a compound of the formula: ##STR2## wherein R.sub.3 is C.sub.1 to C.sub.4 alkyl or phenyl, with a compound of the formula:R.sub.4 --Xwherein R.sub.4 is C.sub.1 to C.sub.6 alkyl or phenyl-alkyl where the alkyl is C.sub.1 to C.sub.4 and X is halogen, in the presence of a base to yield a compound of the formula: ##STR3## and; (b) cyclizing the compound formed during step (a) with ethylenediamine mono-p-toluenesulphonate at a temperature of 100.degree. to 200.degree. C. to yield the desired product. New intermediate compounds are also disclosed. The desired products have antihypertensive properties.
    Type: Grant
    Filed: January 9, 1980
    Date of Patent: September 22, 1981
    Assignee: DSO "Pharmachim"
    Inventors: Atanas G. Georgiev, Kino D. Andreev, Kina V. Konstantinova
  • Derivatives of R,S-[X2-(2-hydroxyethylamino)-1-phenyl]-ethylamine, and process
    Patent number: 4179460
    Abstract: An R,S-[2-(2-hydroxyethylamino)-1-phenyl]-ethylamine of the formula III ##STR1## wherein R represents hydrogen, allyl, propargyl or benzyl. These compounds provide valuable intermediates for the synthesis of Tetramisole.
    Type: Grant
    Filed: June 30, 1978
    Date of Patent: December 18, 1979
    Assignee: DSO "Pharmachim"
    Inventors: Atanas G. Georgiev, Hristo P. Daskalov, Ventzel G. Michaylov, Kina V. Konstantinova
  • 5-Substituted derivatives of 5H-dibenz (b,f)-azepine and method for obtaining the same
    Patent number: 4124583
    Abstract: The invention covers the following compounds: 5-(N-benzoylthiocarbamoyl)-5H-dibenz [b, f] azepine, 5-thiocarbamoyl-5H-dibenz [b,f] azepine, 5-(S-methylisothiocarbamoyl)-5H-dibenz [b,f]-azepine and their 10,11-dihydro analogs. These compounds are intermediates for psychoactive drugs.
    Type: Grant
    Filed: August 19, 1976
    Date of Patent: November 7, 1978
    Assignee: DSO "Pharmachim"
    Inventors: Atanas G. Georgiev, Hristo P. Daskalov