Patents by Inventor Atsushi Mahara

Atsushi Mahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11253626
    Abstract: Provided is a use for a peptide in surface-treating a medical device or medical material to be used in contact with blood, with which it is possible to obtain a medical device or medical material that can achieve highly efficient vascular endothelialization through the use of a peptide uniquely binding to vascular endothelial cells. Also provided are: a peptide suitable for use in said surface treatment; a method for producing a medical device or medical material surfaced-treated with said peptide and to be used in contact with blood; and a surface treatment agent including said peptide, said agent to be used in surface-treating a medical device or medical material to be used in contact with blood. In the present invention, a medical device or medical material is surface-treated using a peptide that includes any one of ten specific amino acid sequences and uniquely binds to the surface of endothelial progenitor cells.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 22, 2022
    Assignees: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, JMS CO., LTD.
    Inventors: Tetsuji Yamaoka, Maria Chiara Munisso, Atsushi Mahara, Takashi Yamamoto
  • Publication number: 20190365944
    Abstract: Provided is a use for a peptide in surface-treating a medical device or medical material to be used in contact with blood, with which it is possible to obtain a medical device or medical material that can achieve highly efficient vascular endothelialization through the use of a peptide uniquely binding to vascular endothelial cells. Also provided are: a peptide suitable for use in said surface treatment; a method for producing a medical device or medical material surfaced-treated with said peptide and to be used in contact with blood; and a surface treatment agent including said peptide, said agent to be used in surface-treating a medical device or medical material to be used in contact with blood. In the present invention, a medical device or medical material is surface-treated using a peptide that includes any one of ten specific amino acid sequences and uniquely binds to the surface of endothelial progenitor cells.
    Type: Application
    Filed: January 30, 2018
    Publication date: December 5, 2019
    Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, JMS CO., LTD.
    Inventors: Tetsuji YAMAOKA, Maria MUNISSO, Atsushi MAHARA, Takashi YAMAMOTO
  • Patent number: 9642695
    Abstract: In order to provide an artificial blood vessel that can prevent formation of a thrombus and a method for producing the artificial blood vessel, an artificial blood vessel is used (i) in which a peptide including a specific amino acid sequence has been added to an extracellular matrix obtained from a bio-derived vascular tissue and (ii) whose lumen has a cross sectional diameter of 4 mm or less.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: May 9, 2017
    Assignee: JMS CO., LTD.
    Inventors: Tetsuji Yamaoka, Atsushi Mahara
  • Publication number: 20150272719
    Abstract: In order to provide an artificial blood vessel that can prevent formation of a thrombus and a method for producing the artificial blood vessel, an artificial blood vessel is used (i) in which a peptide including a specific amino acid sequence has been added to an extracellular matrix obtained from a bio-derived vascular tissue and (ii) whose lumen has a cross sectional diameter of 4 mm or less.
    Type: Application
    Filed: September 5, 2013
    Publication date: October 1, 2015
    Inventors: Tetsuji Yamaoka, Atsushi Mahara
  • Patent number: 8834887
    Abstract: To provide a drug for actively metabolizing or excreting a pathogen occurring in vivo. The present invention is directed to a compound which is formed of (A) an adsorbent for a pathogen occurring in the blood or lymph, and (B) a ligand which is specific to an organ or cells capable of metabolizing or excreting the pathogen and which is bonded to the adsorbent via a linker or with no linker, and to a drug containing the same.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: September 16, 2014
    Assignees: National Cerebral and Cardiovascular Center, Kowa Co., Ltd.
    Inventors: Tetsuji Yamaoka, Mariko Shiba, Atsushi Mahara, Yoshihito Kato
  • Publication number: 20100209441
    Abstract: To provide a drug for actively metabolizing or excreting a pathogen occurring in vivo. The present invention is directed to a compound which is formed of (A) an adsorbent for a pathogen occurring in the blood or lymph, and (B) a ligand which is specific to an organ or cells capable of metabolizing or excreting the pathogen and which is bonded to the adsorbent via a linker or with no linker, and to a drug containing the same.
    Type: Application
    Filed: September 25, 2008
    Publication date: August 19, 2010
    Applicants: JAPAN AS REP. BY THE PRES. OF NAT'L. CARDIO CENTR, KOWA CO., LTD.
    Inventors: Tetsuji Yamaoka, Mariko Shiba, Atsushi Mahara, Yoshihito Kato