Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A control device and a diagnostic method according to the present invention is applicable to an internal combustion engine provided with a first fuel injection valve and a second fuel injection valve for a cylinder. When there is an abnormality that makes an air-fuel ratio of the internal combustion engine richer than a specified value, it is determined whether the first fuel injection valve or the second fuel injection valve has the abnormality, based on change of the air-fuel ratio occurring as a result of first injection control for performing fuel injection while changing a distribution ratio of a fuel injection amount distributed to the first fuel injection valve to a fuel injection amount distributed to the second fuel injection valve, and a value of the air-fuel ratio obtained as a result of second injection control for performing fuel injection while maintaining the distribution ratio at a predetermined ratio.

Abstract: The fuel injection control device and fuel injection control method according to the present invention allow a fuel injection device to perform fuel injection in the case where an open period of the intake valve and an open period of the exhaust valve overlap with each other, and sets the timing to start injection to the closing timing of the exhaust valve, and that sets the timing to end injection to the timing at which a deceleration rate of intake air speed becomes the local maximum. As such, the homogeneity of in-cylinder air-fuel mixture can be improved while preventing the adhesion of fuel to the inner wall of the intake port and the blow-through of fuel to the exhaust passage from occurring.

Abstract: A fuel injection control device and a fuel injection control method according to the present invention are applied to an internal combustion engine including a blow-by gas recirculation device configured to return blow-by gas into an intake passage. According to the present invention, a dilution ratio which indicates how much lubricating oil of the internal combustion engine is diluted with unburned fuel mixed in the lubricating oil is determined. Then, fuel reduction control for reducing fuel supply to the internal combustion engine by a subtractive fuel amount depending on the dilution ratio is performed in a period from an onset of start-up of the internal combustion engine to when a number of combustion cycles accumulated from the onset of the engine start-up reaches a threshold value.

Abstract: The fuel injection control device and fuel injection control method according to the present invention allow a fuel injection device to perform fuel injection in the case where an open period of the intake valve and an open period of the exhaust valve overlap with each other, and sets the timing to start injection to the closing timing of the exhaust valve, and that sets the timing to end injection to the timing at which a deceleration rate of intake air speed becomes the local maximum. As such, the homogeneity of in-cylinder air-fuel mixture can be improved while preventing the adhesion of fuel to the inner wall of the intake port and the blow-through of fuel to the exhaust passage from occurring.

Abstract: The cooling device according to the present invention includes an electric water pump for circulating cooling water through an internal combustion engine of a vehicle, and controls the discharge flow rate of the electric water pump as follows. Until the cooling water temperature. TW reaches a warm-up completion determination temperature, the cooling device increases the discharge flow rate along with an increase of the cooling water temperature TW. After the cooling water temperature TW reaches the warm-up completion determination temperature, the cooling device controls the discharge flow rate so as to bring the combustion chamber wall temperature TCYL toward a target temperature. Thereby, the cooling device can warm up the internal combustion engine more efficiently, and improve the combustion performance of the internal combustion engine after the completion of warm-up.

Abstract: At cold start of an internal combustion engine having an EGR system configured to recirculate, to an intake system, a portion of exhaust gas from the internal combustion engine, supply of a coolant to an EGR cooler and an air conditioning heater which are provided in a coolant circuit for circulating the coolant through the internal combustion engine and an outside thereof is shut off, when a temperature of the coolant is less than a predetermined temperature, and supply of the coolant to the air conditioning heater is allowed and supply of the coolant to the EGR cooler is shut off until the EGR system is activated, when the temperature of the coolant is equal to or higher than the predetermined temperature.

Abstract: A side airbag device including an airbag (2); an inflator (3); and an inner tube (4) formed of a fabric and covering discharge holes (3a) of the inflator (3). The inner tube (4) protrudes toward a center of the airbag (2) in a deployed state and a first end (4b) is closed in the direction of gas discharge, and second ends (4c) that are in a vehicle height direction of the airbag (2) in the deployed state are open. The inner tube (4) is folded back at a folded-back portion (4d) inside the airbag (2) when the airbag (2) is folded in a case where the side airbag device is installed in a vehicle seat back.

Abstract: At cold start of an internal combustion engine having an EGR system configured to recirculate, to an intake system, a portion of exhaust gas from the internal combustion engine, supply of a coolant to an EGR cooler and an air conditioning heater which are provided in a coolant circuit for circulating the coolant through the internal combustion engine and an outside thereof is shut off, when a temperature of the coolant is less than a predetermined temperature, and supply of the coolant to the air conditioning heater is allowed and supply of the coolant to the EGR cooler is shut off until the EGR system is activated, when the temperature of the coolant is equal to or higher than the predetermined temperature.

Abstract: A side airbag device including: a bag-shaped airbag that deploys from a lateral portion of a vehicle seat toward a front side of a vehicle; and an inflator that supplies inflation gas into the airbag. The airbag has, at least at a lower portion thereof, a lower tuck-in region tucked into the airbag. Further, at least a part of the lower tuck-in region is folded into a fan shape and forms a radial folded region folded into a pleated shape along a line extending rearward in a radial direction from a central point of the fan shape positioned on a front side of the airbag.

Abstract: The present invention provides a cooling device for an internal combustion engine of a vehicle. While the vehicle is in a decelerating state and while the internal combustion engine is in an idle reduction state, the cooling device increases the ratio of the cooling water circulation rate through a first path which extends through a heater core and a radiator while reducing the ratio of the cooling water circulation rate through a second path which bypasses the heater core and radiator. In addition, the cooling device increases the discharge flow rate of the electric water pump while the vehicle is in a decelerating state, and maintains the electric water pump in an operating state during idle reduction. Thus, the present invention allows accelerating the temperature decrease of the cylinder head during idle reduction, as well as improving fuel economy during acceleration when the vehicle is started.

Abstract: In a control device for an internal combustion engine and a method of estimating a combustion chamber-wall temperature of an internal combustion engine of the invention, a difference between a wall temperature of the combustion chamber and a cooling water temperature is set according to an integrated value of the intake air amount of the internal combustion engine after start of the fuel-cut, and the estimated value of the wall temperature of the combustion chamber during the fuel-cut is obtained based on the difference and the cooling water temperature.

Abstract: The present invention provides a cooling system for an internal combustion engine, comprising: a flow channel switching valve for switching between a plurality of cooling water channels at least including a heater line for air heating, a block line for cooling an engine block, and a transmission line for an oil warmer of a transmission so as to sequentially open at least one of the plurality of cooling water channels in accordance with a warm-up state of the internal combustion engine; and a control device for controlling opening and closing of the flow channel switching valve so as to restrict a cooling water distribution rate of the heater line. The cooling system allows acceleration of cooling water temperature recovery from a temporary drop.

Abstract: A cooling device for an internal combustion engine of a vehicle according to the claimed invention includes: an electric water pump; a first path including a cooling water passage in a cylinder head and extending through a heater core for air heating and a radiator; and a second path bypassing the heater core and radiator. When the internal combustion engine is automatically stopped while the vehicle is stopping, the cooling device causes the electric water pump to operate, and increases the cooling water circulation ratio through the first path while reducing the cooling water circulation ratio through the second path. Thereby, the cooling device improves fuel economy during acceleration at the vehicle start from the automatic stop state of the internal combustion engine while suppressing the deterioration of the air heating performance during the automatic stop of the internal combustion engine while the vehicle is stopping.

Abstract: A cooling system of an internal combustion engine includes a flow channel switching valve for sequentially switching between a plurality of cooling water passages so as to distribute cooling water to at least one cooling water passage. When a control device for the cooling system switches between the cooling water passages by controlling the flow channel switching valve in accordance with the progress of warm-up of the internal combustion engine, the control device suppresses the distribution rate of the cooling water to the cooling water passage to which the distribution of the cooling water is just started.

Abstract: A side airbag device including: a bag-shaped airbag that deploys from a lateral portion of a vehicle seat toward a front side of a vehicle; and an inflator that supplies inflation gas into the airbag. The airbag has, at least at a lower portion thereof, a lower tuck-in region tucked into the airbag. Further, at least a part of the lower tuck-in region is folded into a fan shape and forms a radial folded region folded into a pleated shape along a line extending rearward in a radial direction from a central point of the fan shape positioned on a front side of the airbag.

Abstract: In a control device for an internal combustion engine and a method of estimating a combustion chamber-wall temperature of an internal combustion engine of the invention, a difference between a wall temperature of the combustion chamber and a cooling water temperature is set according to an integrated value of the intake air amount of the internal combustion engine after start of the fuel-cut, and the estimated value of the wall temperature of the combustion chamber during the fuel-cut is obtained based on the difference and the cooling water temperature.

Abstract: The present invention relates to a cooling control apparatus which performs control for cooling an internal combustion engine by causing an electric pump to circulate cooling water and causing an electric fan to supply cooling air to a radiator. The cooling control apparatus comprises an electric pump for circulating a coolant through a coolant passage formed in the internal combustion engine, and a radiator and a radiator fan which are for cooling the coolant. When the internal combustion engine stops after completion of warming-up, the radiator fan and the electric pump are driven to cool the internal combustion engine, and when a temperature of the coolant decreases to less than a temperature at a time of engine stop, the radiator fan is stopped in a state in which the electric pump is operated.

Abstract: The present invention relates to a cooling device of internal combustion engine for vehicle and a control method thereof. The cooling device according to the present invention includes: an electric water pump; a bypass line bypassing a radiator; and a flow rate control valve for controlling a flow rate of cooling water circulating through the bypass line. During a low external air temperature state where the external air temperature is below a threshold, the cooling device increases the temperature of the cooling water by increasing the flow rate of the cooling water circulating through the bypass line as compared to during a high external air temperature state where the external air temperature is above the threshold, and increases a circulation flow rate of the cooling water by increasing a discharge flow rate of the electric water pump as compared to during the high external air temperature state.

Abstract: The present invention provides a cooling device for an internal combustion engine of a vehicle. While the vehicle is in a decelerating state and while the internal combustion engine is in an idle reduction state, the cooling device increases the ratio of the cooling water circulation rate through a first path which extends through a heater core and a radiator while reducing the ratio of the cooling water circulation rate through a second path which bypasses the heater core and radiator. In addition, the cooling device increases the discharge flow rate of the electric water pump while the vehicle is in a decelerating state, and maintains the electric water pump in an operating state during idle reduction. Thus, the present invention allows accelerating the temperature decrease of the cylinder head during idle reduction, as well as improving fuel economy during acceleration when the vehicle is started.