Patents by Inventor Atul Prakash Kahol
Atul Prakash Kahol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110092585Abstract: The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscosa along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.Type: ApplicationFiled: September 1, 2010Publication date: April 21, 2011Applicants: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Suman Preet Singh Khanuja, Anirban Pal, Sunil Kumar Chattopadhyay, Mahendra Pandurang Darokar, Rajendra Prasad Patel, Anil Kumar Gupta, Arvind Singh Negi, Tanpreet Kaur, Sudeep Tandon, Atul Prakash Kahol, Ankur Garg
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Patent number: 7527814Abstract: The invention provides a simple method for isolation of calliterpenone (16?,17 dihydroxy-3-oxo phyllocladane), a phyllocladane diterpenoid with the plant growth regulating properties, from plant genus Callicarpa.Type: GrantFiled: January 30, 2007Date of Patent: May 5, 2009Assignee: Council of Scientific and Industrial ResearchInventors: Anil Kumar Singh, Suman Preet Singh Khanuja, Sudeep Tandon, Alok Kalra, Deeptanjali Sahoo, Atul Prakash Kahol, Madan Mohan Gupta, Ram Kishor Verma, Arun Kumar Kukreja, Mansoor Alam, Guru Das Bagachi, Ravi Prakash Bansal, Mahendra Pandurang Darokar, Anil Kumar Gupta
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Patent number: 6833143Abstract: The present invention provides a novel process for the preparation of bacosides enriched fraction in a non-hygroscopic form the extract of Bacopa monniera, the said process comprising the steps of drying freshly harvested herb in a hot air oven at 37-42° C.Type: GrantFiled: March 26, 2003Date of Patent: December 21, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Atul Prakash Kahol, Tarun Singh, Sudeep Tandon, Madan Mohan Gupta, Suman Preet Singh Khanuja
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Patent number: 6685972Abstract: The present invention relates to a process for the isolation of artemisinin, an antimalarial agent from the herb of the Artemisia annua plant, comprising of extracting the herb with ethanol, partitioning of the extract between water and hexane, followed by evaporative crystallization of artemisinin from hexane phase to produce substantially pure artemisinin.Type: GrantFiled: March 27, 2002Date of Patent: February 3, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Sushil Kumar, Shiv Kumar Gupta, Digvijay Singh, Madan Mohan Gupta, Dharam Chand Jain, Atul Prakash Kahol, Suman Preet Singh Khanuja, Govind Ram
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Patent number: 6683193Abstract: The present invention relates to an improved method for the preparation of Artemether. Artemether prepared from the process is useful for the treatment of uncomplicated, severe complicated and multi drug resistant malaria.Type: GrantFiled: March 25, 2002Date of Patent: January 27, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Rajendra Singh Bhakuni, Tarun Singh, Atul Prakash Kahol, Amit Tewari, Sundeep Tandon, Suman Preet Singh Khanuja
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Patent number: 6677463Abstract: The present invention provides a single pot process for the preparation of artesunic acid from artemisinin involving reduction followed by esterification of the reduced product at room temperature.Type: GrantFiled: December 10, 2002Date of Patent: January 13, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Rajendra Singh Bhakuni, Atul Prakash Kahol, Tarun Singh, Suman Preet Singh Khanuja
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Publication number: 20030185914Abstract: The present invention relates to a process for the isolation of artemisinin, an antimalarial agent from the herb of the Artemisia annua plant, comprising of extracting the herb with ethanol, partitioning of the extract between water and hexane, followed by evaporative crystallization of artemisinin from hexane phase to produce substantially pure artemisinin.Type: ApplicationFiled: March 27, 2002Publication date: October 2, 2003Inventors: Sushil Kumar, Shiv Kumar Gupta, Digvijay Singh, Madan Mohan Gupta, Dharam Chand Jain, Atul Prakash Kahol, Suman Preet Singh Khanuja, Govind Ram
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Publication number: 20030181513Abstract: The present invention relates to an improved method for the preparation of Artemether. Artemether prepared from the process is useful for the treatment of uncomplicated, severe complicated and multi drug resistant malaria.Type: ApplicationFiled: March 25, 2002Publication date: September 25, 2003Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Rajendra Singh Bhakuni, Tarun Singh, Atul Prakash Kahol, Amit Tewari, Sudeep Tandon, Suman Preet Singh Khanuja
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Patent number: 6589780Abstract: A bio-reactor for enhancing the biomass yield using a closed sterile vessel having a medium, said reactor comprising a central shaft, a support matrix oriented horizontally and dividing the vessel into an upper and a lower chamber, a means for stirring selected from turbine-2,4,6-impeller; marine blade impeller; helical blade impeller; mounted onto the central shaft and located at a predetermined distance from the support matrix so as to generate both radially and axially directed volumetric flow of the media; and at least two semi-circular spargers located both in the upper and lower compartments of the vessel at a predetermined distance from the support matrix.Type: GrantFiled: December 15, 2000Date of Patent: July 8, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Suchitra Banerjee, Arun Kumar Kukreja, Praveen Chandra Verma, Atul Prakash Kahol, Sushil Kumar
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Publication number: 20020076815Abstract: A bio-reactor for enhancing the biomass yield using a closed sterile vessel having a medium, said reactor comprising a central shaft, a support matrix oriented horizontally and dividing the vessel into an upper and a lower chamber, a means for stirring selected from turbine-2,4,6-impeller; marine blade impeller; helical blade impeller; mounted onto the central shaft and located at a predetermined distance from the support matrix so as to generate both radially and axially directed volumetric flow of the media; and at least two semi-circular sparges located both in the upper and lower compartments of the vessel at a predetermined distance from the support matrix.Type: ApplicationFiled: December 15, 2000Publication date: June 20, 2002Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Suchitra Banerjee, Arun Kumar Kukreja, Praveen Chandra Verma, Atul Prakash Kahol, Sushil Kumar
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Patent number: 6337095Abstract: The invention relates to a process for the isolation of compound scopoletin which is used as nitric oxide synthesis inhibitor from Artemisia annua and other plant families, said process comprising extraction of dried powdered material of different plant parts with an aqueous acetonitrite solvent in the ratio of 1:5 for 6 to 8 hrs., concentration of the extracted solvent upto 30% of its original extract under vacuum, partitioning the concentrated extract with halogenated solvent to transfer scopoletin in the non-polar halogenated solvent, drying halogenated solvent over anhydrous sodium sulphate and evaporating the solvent, crystallizing the residues in methanol and filtering the crystals, concentrating the filtrate and chromatographed on silica gel, eluting scopoletin in chloroform methanol mixture; and crystallization of the fractions containing the scopoletin to get the pure scopoletin compound.Type: GrantFiled: March 30, 2000Date of Patent: January 8, 2002Assignee: Council of Scientific and Industrial ResearchInventors: Dharam Chand Jain, Neerja Pant, Madan Mohan Gupta, Rajendra Singh Bhakuni, Ram Kishor Verma, Sudeep Tandon, Shiv Kumar Gupta, Amit Tewari, Atul Prakash Kahol, Sushil Kumar
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Patent number: 6309678Abstract: The invention relates to a novel process for the isolation of a hepatoprotective agent Silymarin from the seeds of the plant Silybum marianum comprising (i) Precooling the seeds to (−) 20° C. for 24 hours in a deep freezer/cold room. (ii) Powdering the cooled seeds in a hammer mill, fitted with about 40 mesh discharge screen. (iii) Defatting the seeds by extracting with hexane in a soxhlet type extractor to remove the total quantity of fatty oil without using a scrain. (iv) Extracting the defatted seeds with acetonitrile at 20-30° C. to extract silymarin fraction. (v) Concentration of the sensitive silymarin fraction under vacuum in a agitated wiped thin film evaporator (vi) stirring the silymarin such dry powder with cold dichloromethane at 5° C. followed by filtration and drying with a slow purge of nitrogen gas. (vii) Further purification of silymarin by suspending in 5 times its weight of acetonitrile and precipitating by 8-12 times its weight of water at 20° C.Type: GrantFiled: March 31, 2000Date of Patent: October 30, 2001Assignee: Council of Scientific and Industrial ResearchInventors: Atul Prakash Kahol, Kiran Lata Singh, Sudeep Tandon, Sushil Kumar
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Patent number: 5955084Abstract: This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane-benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substantially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to form artemisinin.Type: GrantFiled: October 6, 1997Date of Patent: September 21, 1999Inventors: Dharam Chand Jain, Sudeep Tandon, Rajendra Singh Bhakuni, Mohammed Shafique Siddique, Atul Prakash Kahol, Ram Prakash Sharma, Sushil Kumar, Asish Kumar Bhattacharya