Patents by Inventor Avak Kahvejian

Avak Kahvejian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20230035892
    Abstract: The present invention provides methods for treating cancer using GRK2 inhibitors such as small molecule inhibitors of GRK2 among others. The invention also features compositions containing GRK2 inhibitors, methods of diagnosing patients with GRK2-associated cancer and methods of predicting the response of cancer in a subject to treatment with GRK2 inhibitors.
    Type: Application
    Filed: September 3, 2020
    Publication date: February 2, 2023
    Inventors: Jordi MATA-FINK, Avak KAHVEJIAN, Jonathan Barry HUROV, Alexandra LANTERMANN
  • Methods and compositions for immunomodulation
    Patent number: 11554141
    Abstract: Provided are cells containing exogenous antigen and uses thereof.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: January 17, 2023
    Assignee: Rubius Therapeutics, Inc.
    Inventors: Jordi Mata-Fink, John Round, Noubar B. Afeyan, Avak Kahvejian
  • ANELLOVIRUS COMPOSITIONS AND METHODS OF USE
    Publication number: 20220362315
    Abstract: This invention relates generally to viral vectors and viral particles based on Anelloviruses, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.
    Type: Application
    Filed: June 21, 2022
    Publication date: November 17, 2022
    Inventors: Simon Delagrave, Fernando Martin Diaz, Avak Kahvejian, Kevin James Lebo, Dhananjay Maniklal Nawandar, Jared David Pitts, Ryan D. Tedstone, Erica Gabrielle Weinstein, Nathan Lawrence Yozwiak
  • Compositions comprising circular polyribonucleotides and uses thereof
    Patent number: 11458156
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: October 4, 2022
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Alexandra Sophie De Boer, Avak Kahvejian, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
  • COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES FOR PROTEIN MODULATION AND USES THEREOF
    Publication number: 20220305128
    Abstract: This invention relates to compositions comprising circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: June 19, 2020
    Publication date: September 29, 2022
    Inventors: Avak KAHVEJIAN, Nicholas McCartney PLUGIS, Alexandra Sophie DE BOER, Catherine CIFUENTES-ROJAS, Ki Young PAEK
  • METHODS OF DOSING CIRCULAR POLYRIBONUCLEOTIDES
    Publication number: 20220296729
    Abstract: This invention relates generally to methods of dosing pharmaceutical compositions and preparations of circular polyribonucleotides thereof.
    Type: Application
    Filed: June 19, 2020
    Publication date: September 22, 2022
    Inventors: Avak KAHVEJIAN, Alexandra Sophie DE BOER, Nicholas McCartney PLUGIS, Erica Gabrielle WEINSTEIN, Catherine CIFUENTES-ROJAS
  • Anellovirus compositions and methods of use
    Patent number: 11446344
    Abstract: This invention relates generally to viral vectors and viral particles based on Anelloviruses, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: September 20, 2022
    Assignee: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Simon Delagrave, Fernando Martin Diaz, Avak Kahvejian, Kevin James Lebo, Dhananjay Maniklal Nawandar, Jared David Pitts, Ryan D. Tedstone, Erica Gabrielle Weinstein, Nathan Lawrence Yozwiak
  • CIRCULAR RNAS FOR CELLULAR THERAPY
    Publication number: 20220257794
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof in cellular therapy.
    Type: Application
    Filed: June 14, 2020
    Publication date: August 18, 2022
    Inventors: Alexandra Sophie DE BOER, Erica Gabrielle WEINSTEIN, Nicholas McCartney PLUGIS, Catherine CIFUENTES-ROJAS, Morag Helen STEWART, Avak KAHVEJIAN
  • POLYRIBONUCLEOTIDES AND COSMETIC USES THEREOF
    Publication number: 20220142896
    Abstract: Disclosed herein are methods and compositions for delivery of polyribonucleotide. In some cases, the methods and compositions provided herein are suitable for in vivo delivery of polyribonucleotides. In certain aspects, also disclosed herein are cosmetic compositions for delivery of polyribonucleotide having cosmetic effects.
    Type: Application
    Filed: March 1, 2020
    Publication date: May 12, 2022
    Inventors: Avak KAHVEJIAN, Nicholas McCartney PLUGIS, Alexandra Sophie DE BOER, Ellese Marie CARMONA, Morag Helen STEWART
  • CIRCULAR POLYRIBONUCLEOTIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20220143062
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: March 4, 2020
    Publication date: May 12, 2022
    Inventors: Avak KAHVEJIAN, Nicholas McCartney PLUGIS, Alexandra Sophie DE BOER, Catherine CIFUENTES-ROJAS, Ki Young PAEK, Michael Donato MELFI
  • COMPOSITIONS, METHODS, AND KITS FOR DELIVERY OF POLYRIBONUCLEOTIDES
    Publication number: 20220088049
    Abstract: Disclosed herein are methods and compositions for delivery of a polyribonucleotide. In some cases, the methods and compositions provided herein are suitable for in vivo delivery of polyribonucleotides. In certain aspects, also disclosed herein are pharmaceutical compositions for delivery of polyribonucleotide having biological effects.
    Type: Application
    Filed: March 1, 2020
    Publication date: March 24, 2022
    Inventors: Avak KAHVEJIAN, Nicholas McCartney PLUGIS, Alexandra Sophie DE BOER, Ellese Marie CARMONA, Morag Helen STEWART, Roger Joseph HAJJAR
  • Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators
    Patent number: 11274158
    Abstract: The present invention provides methods for treating inflammatory or autoimmune disease using calcitonin receptor activators, such as calcitonin receptor activating antibodies, among others. The invention also features compositions containing calcitonin receptor activators, methods of diagnosing patients with calcitonin receptor-associated inflammatory or autoimmune disease, and methods of predicting the response of an inflammatory or autoimmune disease or condition in a subject to treatment with calcitonin receptor activators.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: March 15, 2022
    Assignee: Flagship Pioneering Innovations V, Inc.
    Inventors: Avak Kahvejian, Jordi Mata-Fink, Jonathan Barry Hurov, Chengyi Jenny Shu, George Huck Neubauer, Manuel Andreas Fankhauser, Julian Alexander Stanley
  • Amplifiable RNAs for Therapeutic Cell Systems
    Publication number: 20220073875
    Abstract: This disclosure provides, among other things, amplifiable nucleic acid constructs for expressing a gene of interest in a cell, e.g., an erythroid cell. The amplifiable nucleic acid construct may contain the gene of interest and an RNA-dependent RNA polymerase (RdRP)-responsive 5? UTR, and may optionally further contain an RdRP-responsive 3? UTR. RdRP may also be provided, e.g., on the same construct or a different construct.
    Type: Application
    Filed: November 18, 2021
    Publication date: March 10, 2022
    Applicant: Rubius Therapeutics, Inc.
    Inventors: Qin Yu, Urjeet Khanwalkar, Omid Harandi, Ewan Dunn, Tanyaporn Pattarabanjird, Avak Kahvejian, Jordi Mata-Fink
  • Compositions and Methods Related to Multimodal Therapeutic Cell Systems for Autoimmune Indications
    Publication number: 20220072048
    Abstract: The invention includes compositions and methods related to multimodal therapies, e.g., for treating immune conditions. A multimodal therapy described herein provides and/or administers a plurality of agents that function in a coordinated manner to provide a therapeutic benefit to a subject in need thereof, e.g., a subject having an autoimmune disease or inflammatory disease.
    Type: Application
    Filed: November 17, 2021
    Publication date: March 10, 2022
    Applicant: Rubius Therapeutics, Inc.
    Inventors: Avak Kahvejian, Jordi Mata-Fink, Robert J. Deans, Tiffany F. Chen, John Round, Noubar B. Afeyan, Torben Straight Nissen, Nathan Dowden, Tom Wickham
  • ANELLOSOMES FOR DELIVERING PROTEIN REPLACEMENT THERAPEUTIC MODALITIES
    Publication number: 20220073950
    Abstract: This invention relates generally to anellosomes and compositions and uses thereof.
    Type: Application
    Filed: December 12, 2019
    Publication date: March 10, 2022
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • ANELLOSOMES FOR DELIVERING INTRACELLULAR THERAPEUTIC MODALITIES
    Publication number: 20220040117
    Abstract: This invention relates generally to anellosomes and compositions and uses thereof.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 10, 2022
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • ANELLOSOMES AND METHODS OF USE
    Publication number: 20220042042
    Abstract: This invention relates generally to anellosomes and compositions and uses thereof.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 10, 2022
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • METHODS AND COMPOSITIONS FOR TREATING CANCER USING CHRNA6 INHIBITORS
    Publication number: 20220033490
    Abstract: The present invention provides methods for treating cancer using a6*nAChR inhibitors, such as a6*nAChR inhibitory antibodies, among others. The invention also features compositions containing a6*nAChR inhibitors, methods of diagnosing patients with a6*nAChR-associated cancer, and methods of predicting the response of cancer in a subject to treatment with a6*nAChR inhibitors.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 3, 2022
    Inventors: Avak KAHVEJIAN, Jordi MATA-FINK, Jonathan Barry HUROV, Chengyi Jenny SHU, Manuel Andreas FANKHAUSER, Julian Alexander STANLEY
  • COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES AND USES THEREOF
    Publication number: 20220023331
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: September 22, 2021
    Publication date: January 27, 2022
    Inventors: Alexandra Sophie DE BOER, Avak KAHVEJIAN, Nicholas McCartney PLUGIS, Erica Gabrielle WEINSTEIN, Sebastian TROUSIL, Morag Helen STEWART, Ki Young PAEK, Catherine CIFUENTES-ROJAS
  • Methods and compositions for treating inflammatory or autoimmune diseases or conditions using serotonin receptor activators
    Patent number: 11208475
    Abstract: The present invention provides methods for treating inflammatory or autoimmune diseases or conditions using serotonin receptor activators, such as serotonin receptor activating antibodies, among others. The invention also features compositions containing serotonin receptor activators, methods of diagnosing patients with a serotonin receptor-associated inflammatory or autoimmune disease or condition, and methods of predicting the response of an inflammatory or autoimmune disease or condition in a subject to treatment with serotonin receptor activators.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: December 28, 2021
    Assignee: Flagship Pioneering Innovations V, Inc.
    Inventors: Avak Kahvejian, Jordi Mata-Fink, Jonathan Barry Hurov, Chengyi Jenny Shu, George Huck Neubauer, Manuel Andreas Fankhauser, Julian Alexander Stanley