Patent number: 8729279
Abstract: Agents or pharmaceutical compositions for promoting osteoblast differentiation include purified auraptene or coumarin analogs thereof represented by the following formula 1: wherein R1 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, or a carboxyethyl; R2 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, a carboxyethyl or a coumarinyl; R3 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl or a carboxyethyl; and R4 represents a hydrogen, a C1-C15 liner or branched alkyl, an alkenyl, an alkadienyl or an alkatrienyl.
Type:
Grant
Filed:
February 28, 2011
Date of Patent:
May 20, 2014
Assignee:
Erina Co., Inc.
Inventors:
Je-Tae Woo, Ayaka Hibino, Takayuki Yonezawa, Midori Asai, Toshiaki Teruya, Byung-Yoon Cha, Kazuo Nagai
Publication number: 20130102796
Abstract: Agents or pharmaceutical compositions for promoting osteoblast differentiation include purified auraptene or coumarin analogs thereof represented by the following formula 1: wherein R1 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, or a carboxyethyl; R2 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, a carboxyethyl or a coumarinyl; R3 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl or a carboxyethyl; and R4 represents a hydrogen, a C1-C15 liner or branched alkyl, an alkenyl, an alkadienyl or an alkatrienyl.
Type:
Application
Filed:
February 28, 2011
Publication date:
April 25, 2013
Applicant:
ERINA CO., INC.
Inventors:
Je-Tae Woo, Ayaka Hibino, Takayuki Yonezawa, Midori Asai, Toshiaki Teruya, Byung-Yoon Cha, Kazuo Nagai
