Patents by Inventor Ayako SASAKI

Ayako SASAKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10551387
    Abstract: A cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with a pre-existing dyeing method for cytodiagnosis. The method uses living body-derived cells and includes: incubating living cells included in a sample taken from a person together with a fluorescently-labeled L-glucose derivative and detecting the fluorescently-labeled L-glucose derivative that is taken up into the cells; and detecting fluorescence emitted by the L-glucose derivative that is present within the cells while the cells are attached to a thin glass or plastic plate. Also provided is a dual detection method for cancer cells in which the cancer cell detection method that uses living body-derived cells is combined with a dyeing method using cells that are fixed using an alcohol or the like.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: February 4, 2020
    Assignee: HIROSAKI UNIVERSITY
    Inventors: Katsuya Yamada, Ayako Sasaki, Kouki Ono, Kiyoshi Tone
  • Patent number: 10509041
    Abstract: Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided is a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: December 17, 2019
    Assignee: HIROSAKI UNIVERSITY
    Inventors: Katsuya Yamada, Ayako Sasaki, Tadashi Teshima, Toshihiro Yamamoto, Yuji Otsuka
  • Publication number: 20180238899
    Abstract: Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided is a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.
    Type: Application
    Filed: April 19, 2018
    Publication date: August 23, 2018
    Applicant: HIROSAKI UNIVERSITY
    Inventors: Katsuya YAMADA, Ayako SASAKI, Tadashi TESHIMA, Toshihiro YAMAMOTO, Yuji OTSUKA
  • Patent number: 10001487
    Abstract: Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: June 19, 2018
    Assignee: HIROSAKI UNIVERSITY
    Inventors: Katsuya Yamada, Ayako Sasaki, Tadashi Teshima, Toshihiro Yamamoto, Yuji Otsuka
  • Publication number: 20170315129
    Abstract: The purpose of the present invention is to provide a novel cancer cell detection method that uses living body-derived cells and that can be used even in cytodiagnosis. In particular, the purpose of the present invention is to provide a novel cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with a pre-existing dyeing method for cytodiagnosis. Provided is a cancer cell detection method that uses living body-derived cells and that includes: incubating living cells included in a sample taken from a person together with a fluorescently-labeled L-glucose derivative and detecting the fluorescently-labeled L-glucose derivative that is taken up into the cells; and detecting fluorescence emitted by the L-glucose derivative that is present within the cells while the cells are attached to a thin glass or plastic plate.
    Type: Application
    Filed: September 24, 2015
    Publication date: November 2, 2017
    Applicant: Hirosaki University
    Inventors: Katsuya YAMADA, Ayako SASAKI, Kouki ONO, Kiyoshi TONE
  • Publication number: 20170122955
    Abstract: Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.
    Type: Application
    Filed: April 6, 2015
    Publication date: May 4, 2017
    Applicant: HIROSAKI UNIVERSITY
    Inventors: Katsuya YAMADA, Ayako SASAKI, Tadashi TESHIMA, Toshihiro YAMAMOTO, Yuji OTSUKA