Patents by Inventor Ayako Toda
Ayako Toda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8603975Abstract: The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.Type: GrantFiled: April 25, 2008Date of Patent: December 10, 2013Assignee: Astellas Pharma Inc.Inventors: Toshio Yamanaka, Hidenori Ohki, Junya Ishida, Ayako Toda, Yu Harayama, Takuya Makino, Shigeki Kunikawa, Hiroaki Mizuno, Hiroaki Ohtake
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Publication number: 20100120672Abstract: The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.Type: ApplicationFiled: April 25, 2008Publication date: May 13, 2010Inventors: Toshio Yamanaka, Hidenori Ohki, Junya Ishida, Ayako Toda, Yu Harayama, Takuya Makino, Shigeki Kunikawa, Hiroaki Mizuno, Hiroaki Ohtake
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Publication number: 20090012054Abstract: The present invention provides a compound of the formula [I]: wherein R1 is lower alkyl, etc. and R2 is hydrogen, etc., or R1 and R2 are bonded together to form lower alkylene; R3 is a group represented by wherein R6 and R7 are independently optionally protected amino, etc.; m and n are independently an integer of 0 to 6; R8 and R9 are independently optionally protected amino, etc., and q and r are independently an integer of 0 to 6, or R8 and R9, together with the adjacent alkylene(s) and the nitrogen atom, form saturated nitrogen-containing heterocycle optionally having substituent(s); R4 is lower alkyl, etc.; and R5 is amino, etc., or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 16, 2007Publication date: January 8, 2009Applicants: ASTELLAS PHARMA INC., WAKUNAGA PHARMACEUTICAL CO. LTD.Inventors: Toshio Yamanaka, Ayako Toda, Hidenori Ohki, Shinya Okuda, Kohji Kawabata, Kenji Murano, Kazuo Hatano, Shinobu Takeda, Toru Nakai, Masaru Oogaki, Satoshi Inoue, Keiji Misumi, Kenji Itoh
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Patent number: 7192943Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: GrantFiled: September 17, 2004Date of Patent: March 20, 2007Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd.Inventors: Toshio Yamanaka, Kenji Murano, Ayako Toda, Hidenori Ohki, Masaru Oogaki, Shinya Okuda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Sato
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Publication number: 20070037786Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: ApplicationFiled: October 24, 2006Publication date: February 15, 2007Applicants: WAKUNAGA PHARMACEUTICAL CO., LTD., Astellas Pharma Inc.Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
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Patent number: 7129232Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: GrantFiled: October 30, 2003Date of Patent: October 31, 2006Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., LtdInventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
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Publication number: 20050261177Abstract: This invention relates to new polypeptide compound represented by the following general formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on ?-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.Type: ApplicationFiled: March 7, 2002Publication date: November 24, 2005Inventors: Ayako Toda, Hiroaki Mizuno, Takahiro Matsuya, Hiroshi Matsuda, Kenji Murano, David Barrett, Takashi Ogino, Hitomi Ogino, Keiji Matsuda
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Publication number: 20050181988Abstract: This invention relates to new lipopeptide compound represented by the following general formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on ?-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or thereapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal. In particular, R4 is an alkyl moiety which is substituted with an eventually protected and/or further substituted selected from amino, carboxy, guanidino, heterocyclic-carbonyl, alkyl-carbamoyl.Type: ApplicationFiled: February 4, 2003Publication date: August 18, 2005Inventors: Hiroaki Mizuno, Takahiro Matsuya, Hiroshi Matsuda, David Barrett, Ayako Toda, Keiji Matsuda
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Publication number: 20050096306Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: ApplicationFiled: September 17, 2004Publication date: May 5, 2005Applicants: Fujisawa Pharmaceutical Co. Ltd., Wakunaga Pharmaceutical Co., Ltd.Inventors: Toshio Yamanaka, Kenji Murano, Ayako Toda, Hidenori Ohki, Masaru Oogaki, Shinya Okuda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Sato
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Patent number: 6884774Abstract: This invention relates to new polypeptide compound represented by the general formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on ?-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystic carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.Type: GrantFiled: February 20, 2001Date of Patent: April 26, 2005Assignee: Fujisawa Pharmaceutical Co. Ltd.Inventors: Ayako Toda, Takahiro Matsuya, Hiroaki Mizuno, Hiroshi Matsuda, Kenji Murano, David Barrett, Takashi Ogino, Keiji Matsuda
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Publication number: 20050004094Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl which may have suitable substituent(s), R2 is amino, protected amino or guanidino, R3 is carboxy or protected carboxy, R4 is amino or protected amino, and A is lower alkylene, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: ApplicationFiled: April 28, 2004Publication date: January 6, 2005Applicants: Fujisawa Pharmaceutical Co., Ltd., WAKUNAGA PHARMACEUTICAL CO., LTD.Inventors: Toshio Yamanaka, Hidenori Ohki, Masaru Ohgaki, Shinya Okuda, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
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Publication number: 20040132994Abstract: The present invention relates to a compound of the formula [I]: 1Type: ApplicationFiled: October 30, 2003Publication date: July 8, 2004Applicants: Fujisawa Pharmaceutical Co., Ltd, WAKUNAGA PHARMACEUTICAL CO., LTD.Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
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Publication number: 20030083238Abstract: This invention relates to new polypeptide compound represented by the general formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystic carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.Type: ApplicationFiled: January 30, 2002Publication date: May 1, 2003Inventors: Ayako Toda, Takahiro Matsuya, Hiroaki Mizuno, Hiroshi Matsuda, Kenji Murano, David Barrett, Takashi Ogino, Keiji Matsuda