Patents by Inventor Aykut Uren

Aykut Uren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SECRETED FRIZZLED RELATED PROTEIN, SFRP, FRAGMENTS AND METHODS OF USE THEREOF
    Publication number: 20110177554
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Application
    Filed: February 18, 2011
    Publication date: July 21, 2011
    Applicants: The Gov. of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services, The University of Massachusetts
    Inventors: JEFFREY S. RUBIN, SUSAN CUMBERLEDGE, FRIEDA REICHSMAN, AYKUT UREN
  • Secreted frizzled related protein, sFRP, fragments and methods of use thereof
    Patent number: 7947651
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: May 24, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Massachusetts
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren
  • TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
    Publication number: 20100167994
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Application
    Filed: March 9, 2010
    Publication date: July 1, 2010
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
    Publication number: 20100004179
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Application
    Filed: June 29, 2009
    Publication date: January 7, 2010
    Inventors: Jeffrey A. Toretsky, Aykut Uren, Milton Lang Brown, Yali Kong
  • SFRP and peptide motifs that interact with SFRP and methods of their use
    Patent number: 7488710
    Abstract: This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: February 10, 2009
    Assignees: The United States of America as represented by the Department of Health and Human Services, St. Vincent's Institute of Medical Research
    Inventors: Jeffrey S. Rubin, Aykut Üren, Matthew Todd Gillespie, Nicole Joy Horwood
  • SECRETED FRIZZLED RELATED PROTEIN, sFRP, FRAGMENTS AND METHODS OF USE THEREOF
    Publication number: 20080207504
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Application
    Filed: May 15, 2007
    Publication date: August 28, 2008
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren
  • Secreted frizzled related protein fragments
    Patent number: 7223853
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: May 29, 2007
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services., The University of Massachusetts
    Inventors: Frieda Reichsman, Aykut Üren, Jeffrey S. Rubin, Susan Cumberledge
  • Sfrp and peptide motifs that interact with sfrp and methods of their use
    Publication number: 20040077828
    Abstract: This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.
    Type: Application
    Filed: July 10, 2003
    Publication date: April 22, 2004
    Inventors: Jeffrey S. Rubin, Aykut Uren, Brian K. Kay, Bernard Weisblum, Matthew Todd Gillespie, Nicole Joy Horwood
  • Secreted frizzled related protein,sFRP, fragments and methods of use thereof
    Publication number: 20030187223
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Application
    Filed: April 28, 2003
    Publication date: October 2, 2003
    Applicants: The Government of the United States of America as represented by the, Secretary of the Department of Health and Human Services, The University of Massachusetts
    Inventors: Frieda Reichsman, Aykut Uren, Jeffrey S. Rubin, Susan Cumberledge
  • Secreted frizzled related protein, sFRP, fragments and methods of use thereof
    Patent number: 6600018
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: July 29, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren