Patents by Inventor Ayumi Osawa

Ayumi Osawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Palladium-mediated ketolization
    Patent number: 10844073
    Abstract: Provided herein are palladium-mediated coupling reactions useful in the preparation of ketone-containing organic molecules. The provided methods can be used for the preparation of natural products and pharmaceutical agents, including Eribulin, halichondrins, and analogs thereof. The present invention also provides novel halichondrin analogs which can be prepared via the palladium-mediated coupling reactions. The novel halichondrin analogs can be used in the prevention and/or treatment of diseases or conditions (e.g., proliferative diseases such as cancer).
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: November 24, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Jung Hwa Lee, Yoshito Kishi, Ayumi Osawa, Zhanjie Li
  • PALLADIUM-MEDIATED KETOLIZATION
    Publication number: 20200002352
    Abstract: Provided herein are palladium-mediated coupling reactions useful in the preparation of ketone-containing organic molecules. The provided methods can be used for the preparation of natural products and pharmaceutical agents, including Eribulin, halichondrins, and analogs thereof. The present invention also provides novel halichondrin analogs which can be prepared via the palladium-mediated coupling reactions. The novel halichondrin analogs can be used in the prevention and/or treatment of diseases or conditions (e.g., proliferative diseases such as cancer).
    Type: Application
    Filed: July 1, 2019
    Publication date: January 2, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: Jung Hwa Lee, Yoshito Kishi, Ayumi Osawa, Zhanjie Li
  • Palladium-mediated ketolization
    Patent number: 10392400
    Abstract: Provided herein are palladium-mediated coupling reactions useful in the preparation of ketone-containing organic molecules. The provided methods can be used for the preparation of natural products and pharmaceutical agents, including Eribulin, halichondrins, and analogs thereof. The present invention also provides novel halichondrin analogs which can be prepared via the palladium-mediated coupling reactions. The novel halichondrin analogs can be used in the prevention and/or treatment of diseases or conditions (e.g., proliferative diseases such as cancer).
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: August 27, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Jung Hwa Lee, Yoshito Kishi, Ayumi Osawa, Zhanjie Li
  • Compound having fluorescent chromophore, ion concentration sensor including compound, reagent including compound, reagent kit provided with reagent, precursor of compound, and method for synthesizing compound
    Patent number: 9222016
    Abstract: A compound of the present invention comprises a triazapentalene backbone represented by the general formula 1 below as a fluorescent chromophore.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: December 29, 2015
    Assignee: National University Corporation Hokkaido University
    Inventors: Kosuke Namba, Ayumi Osawa, Keiji Tanino
  • Compound Having Fluorescent Chromophore, Ion Concentration Sensor Including Compound, Reagent Including Compound, Reagent Kit Provided with Reagent, Precursor of Compound, and Method for Synthesizing Compound
    Publication number: 20140005410
    Abstract: A compound of the present invention comprises a triazapentalene backbone represented by the general formula 1 below as a fluorescent chromophore.
    Type: Application
    Filed: March 8, 2012
    Publication date: January 2, 2014
    Applicant: NATIONAL UNIVERSITY CORPORATION, HOKKAIDO UNIVERSITY
    Inventors: Kosuke Namba, Ayumi Osawa, Keiji Tanino