Patents by Inventor Baishan HU
Baishan HU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230019023Abstract: A sulfur-containing compound and a halogenated aromatic compound are used as raw materials, with an alkaline compound and a fatty acid as polycondensation aids to carry out a polycondensation reaction. After purification treatment, a primary polyphenylene sulfide is obtained which then reacts with a chain extender at high temperature to form a high molecular weight polyphenylene sulfide resin. A preparation method has the advantages of being high yield, low cost, and capable of selectively and controllably preparing polyphenylene sulfide resins with different melt viscosities and molecular weights, and the obtained polyphenylene sulfide resins have excellent heat resistance.Type: ApplicationFiled: September 26, 2022Publication date: January 19, 2023Inventors: Zhirong CHEN, Woyuan LI, Hong YIN, Baishan HU, Guiyang ZHOU, Ming LIAN, Guangde QIN, Hangjun DENG, Xiongwei ZHANG, Guisheng QIU, Kejun WU
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Patent number: 11440996Abstract: A preparation method of a polyphenylene sulfide resin, and a polyphenylene sulfide resin prepared by the method using a sulfur-containing compound, an alkaline substance and p-dichlorobenzene as raw materials, a fatty acid as a polycondensation aid to carry out a polycondensation reaction. After purification treatment, a primary polyphenylene sulfide is obtained, which then reacts with a terminal-group adjusting agent at a high temperature to generate the polyphenylene sulfide resin resulting in high yield and low cost. The prepared polyphenylene sulfide resin has high reactivity, high melting crystallization temperature and excellent thermal stability. The resulting polyphenylene sulfide resin can be directly used for extrusion and injection molding.Type: GrantFiled: July 12, 2018Date of Patent: September 13, 2022Assignees: ZHEJIANG NHU CO., LTD., ZHEJIANG UNIVERSITY, ZHEJIANG NHU SPECIAL MATERIALS CO., LTD.Inventors: Woyuan Li, Hong Yin, Zhirong Chen, Baishan Hu, Guiyang Zhou, Hangjun Deng, Ming Lian, Xiongwei Zhang, Qichuan Li, Jiang Zhao
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Patent number: 11390893Abstract: The present application relates to a method for extracting coenzyme Q10 and a phospholipid from a coenzyme Q10 fermentation bacterium powder. The method is characterized in that the fermentation bacterium powder of a coenzyme Q10 production strain is subjected to extraction with a mixed solvent of which the three-dimensional Hansen solubility parameter is between 21 and 23 (J/cm3)1/2 and the hydrogen bonding solubility parameter thereof is between 10 and 12 (J/cm3)1/2. The present invention can efficiently extract two products, namely coenzyme Q10 and a phospholipid, from the coenzyme Q10 fermentation bacterium powder; the process thereof is highly operable, easy to be industrialized, and can provide a product with high purity and yield, having great economic benefit.Type: GrantFiled: May 23, 2018Date of Patent: July 19, 2022Assignees: ZHEJIANG NHU CO. LTD., ZHEJIANG UNIVERSITY, HEILONGJIANG NHU BIOTECHNOLOGY CO. LTD., SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD.Inventors: Shenfeng Yuan, Yang Yao, Yi Min, Baishan Hu, Zhaofeng Chen, Yong Li, Qichuan Li, Yunxuan Luo, Jinyang Zhang, Xuguang Li, Shichun Tu
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Patent number: 11180440Abstract: The present disclosure relates to a method for preparing isophorone diamine by means of a hydrogenation reduction of isophorone nitrile imine. The hydrogenation reduction is continuously carried out in a multi-stage bubble column reactor loaded with a supported alkaline cobalt-based catalyst, wherein isophorone nitrile imine is successively in countercurrent contact with hydrogen in each stage of the reactor to carry out a hydrogenation reduction reaction, so as to obtain the isophorone diamine. The preparation method solves the problem of back-mixing, and further improves the conversion rate and the cis/trans ratio of the product.Type: GrantFiled: November 30, 2018Date of Patent: November 23, 2021Assignees: Zhejiang Nhu Company Ltd., Zhejiang University, Shandong Nhu Amino Acid Co., Ltd., Shandong Nhu Fine Chemical Science and Technology Company Ltd.Inventors: Zhirong Chen, Jianyong Mao, Baishan Hu, Guanbing Li, Haoran Li, Yu Wang, Yingkuo Yang, Qing Liu, Jiyu Tang, Weiyong Chen
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Patent number: 11130115Abstract: The present invention discloses a selective hydrogenation catalyst and a preparation method and an application thereof, belonging to the technical field of catalysts. The selective hydrogenation catalyst comprises an active component and a carrier for supporting the active component, wherein the active component is a transition metal particle, the carrier is modified by a flexible chain ligand in advance, one end of the flexible chain ligand is uniformly distributed on the surface of the carrier, and the other end of the flexible chain ligand is coordinated on a transition metal. When the catalyst is used for catalytic hydrogenation reaction of dehydrolinalool or 2-methyl-3-butyn-2-ol, the stability is good, the catalyst still has high selectivity after being used for a long time, and the quality of a hydrogenation product can be guaranteed.Type: GrantFiled: July 1, 2020Date of Patent: September 28, 2021Assignees: ZHEJIANG UNIVERSITY, ZHEJIANG NHU COMPANY LTD., SHANDONG NHU PHARMACEUTICAL CO., LTD.Inventors: Haoran Li, Yong Wang, Baishan Hu, Xiao Ma, Dan Qiu, Qian Luo, Zhe Wang, Shanjun Mao, Lili Yu, Qichuan Li
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Patent number: 11130732Abstract: Provided by the present disclosure are a method and a device for preparing 2-hydroxy-4-methylthiobutyric acid and intermediates thereof; the intermediates for preparing 2-hydroxy-4-methylthiobutyric acid comprise 3-methylthiopropionaldehyde and 2-hydroxy-4-methylthiobutyronitrile. The method for preparing 2-hydroxy-4-methylthiobutyric acid provided by the present disclosure comprises: step (1), a step of reacting acrolein with methyl mercaptan to prepare 3-methylthiopropionaldehyde; step (2), a step of reacting 3-methylthiopropionaldehyde with hydrocyanic acid to prepare 2-hydroxy-4-methylthiobutyronitrile; and step (3), a step of hydrating 2-hydroxy-4-methylthiobutyronitrile by using sulfuric acid and then hydrolyzing to prepare 2-hydroxy-4-methylthiobutyric acid; wherein in steps (1), (2) and (3), the reaction status of the materials is detected online, and the proportions of the materials are controlled according to the detection results such that reactions are performed completely.Type: GrantFiled: August 27, 2019Date of Patent: September 28, 2021Assignees: ZHEJIANG NHU CO., LTD., ZHEJIANG UNIVERSITY, SHANDONG NHU AMINO ACID CO., LTD.Inventors: Zhirong Chen, Hong Yin, Baishan Hu, Zhengjiang Wang, Zhixuan Wang, Cong Chen, Guisheng Qiu, Qichuan Li, Qingai Shi
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Publication number: 20210252484Abstract: The present invention discloses a selective hydrogenation catalyst and a preparation method and an application thereof, belonging to the technical field of catalysts. The selective hydrogenation catalyst comprises an active component and a carrier for supporting the active component, wherein the active component is a transition metal particle, the carrier is modified by a flexible chain ligand in advance, one end of the flexible chain ligand is uniformly distributed on the surface of the carrier, and the other end of the flexible chain ligand is coordinated on a transition metal. When the catalyst is used for catalytic hydrogenation reaction of dehydrolinalool or 2-methyl-3-butyn-2-ol, the stability is good, the catalyst still has high selectivity after being used for a long time, and the quality of a hydrogenation product can be guaranteed.Type: ApplicationFiled: July 1, 2020Publication date: August 19, 2021Applicants: ZHEJIANG UNIVERSITY, ZHEJIANG NHU COMPANY LTD., SHANDONG NHU PHARMACEUTICAL CO., LTD.Inventors: Haoran LI, Yong WANG, Baishan HU, Xiao MA, Dan QIU, Qian LUO, Zhe WANG, Shanjun MAO, Lili YU, Qichuan LI
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Publication number: 20210147350Abstract: Provided by the present disclosure are a method and a device for preparing 2-hydroxy-4-methylthiobutyric acid and intermediates thereof; the intermediates for preparing 2-hydroxy-4-methylthiobutyric acid comprise 3-methylthiopropionaldehyde and 2-hydroxy-4-methylthiobutyronitrile.Type: ApplicationFiled: August 27, 2019Publication date: May 20, 2021Applicants: ZHEJIANG NHU COMPANY LTD., ZHEJIANG UNIVERSITY, SHANDONG NHU AMINO ACID CO., LTD.Inventors: Zhirong Chen, Hong Yin, Baishan Hu, Zhengjiang Wang, Zhixuan Wang, Cong Chen, Guisheng Qiu, Qichuan Li, Qingai Shi
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Patent number: 10974225Abstract: The present disclosure belongs to the technical field of catalysis, and particularly relates to a metal oxide coated ceramic corrugated plate catalyst, its preparation method and application thereof in preparation of key intermediates of citral. The catalyst consists of a ceramic corrugated plate carrier and a metal oxide active layer coated on a surface of the carrier, wherein the metal oxide active layer is a metal oxide formed by active ingredient titanium and at least four other metal elements selected from vanadium, chromium, manganese, iron, zirconium, niobium and molybdenum.Type: GrantFiled: July 1, 2020Date of Patent: April 13, 2021Assignees: ZHEJIANG NHU COMPANY LTD., ZHEJIANG UNIVERSITY, SHANDONG NHU PHARMACEUTICAL CO., LTD.Inventors: Haoran Li, Xiao Ma, Yong Wang, Baishan Hu, Dan Qiu, Jianyong Mao, Bing Lu, Shanjun Mao, Lili Yu, Qichuan Li
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Publication number: 20210087133Abstract: The present disclosure relates to a method for preparing isophorone diamine by means of a hydrogenation reduction of isophorone nitrile imine. The hydrogenation reduction is continuously carried out in a multi-stage bubble column reactor loaded with a supported alkaline cobalt-based catalyst, wherein isophorone nitrile imine is successively in countercurrent contact with hydrogen in each stage of the reactor to carry out a hydrogenation reduction reaction, so as to obtain the isophorone diamine. The preparation method solves the problem of back-mixing, and further improves the conversion rate and the cis/trans ratio of the product.Type: ApplicationFiled: November 30, 2018Publication date: March 25, 2021Inventors: Zhirong CHEN, Jianyong MAO, Baishan HU, Guanbing LI, Haoran LI, Yu WANG, Yingkuo YANG, Qing LIU, Jiyu TANG, Weiyong CHEN
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Publication number: 20210047471Abstract: The disclosure relates to a high molecular weight polyphenylene sulfide resin and a preparation method and application thereof. The disclosure uses a sulfur-containing compound and a halogenated aromatic compound as raw materials, an alkaline compound and a fatty acid as polycondensation aids to carry out a polycondensation reaction. After purification treatment, a primary polyphenylene sulfide is obtained. Then, the primary polyphenylene sulfide reacts with a chain extender at a high temperature to form a high molecular weight polyphenylene sulfide resin. The preparation method of the disclosure has the advantages of high yield, low cost, and is capable of selectively and controllably preparing polyphenylene sulfide resins with different melt viscosities and molecular weights, and the obtained polyphenylene sulfide resins have excellent heat resistance.Type: ApplicationFiled: August 23, 2019Publication date: February 18, 2021Inventors: Zhirong CHEN, Woyuan LI, Hong YIN, Baishan HU, Guiyang ZHOU, Ming LIAN, Guangde QIN, Hangjun DENG, Xiongwei ZHANG, Guisheng QIU, Kejun WU
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Publication number: 20200399667Abstract: The present application relates to a method for extracting coenzyme Q10 and a phospholipid from a coenzyme Q10 fermentation bacterium powder. The method is characterized in that the fermentation bacterium powder of a coenzyme Q10 production strain is subjected to extraction with a mixed solvent of which the three-dimensional Hansen solubility parameter is between 21 and 23 (J/cm3)1/2 and the hydrogen bonding solubility parameter thereof is between 10 and 12 (J/cm3)1/2. The present invention can efficiently extract two products, namely coenzyme Q10 and a phospholipid, from the coenzyme Q10 fermentation bacterium powder; the process thereof is highly operable, easy to be industrialized, and can provide a product with high purity and yield, having great economic benefit.Type: ApplicationFiled: May 23, 2018Publication date: December 24, 2020Inventors: Shenfeng YUAN, Yang YOA, Yi MIN, Baishan HU, Zhaofeng CHEN, Yong LI, Qichuan LI, Yunxuan LUO, Jinyang ZHANG, Xuguang LI, Shichun TU
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Publication number: 20200347186Abstract: The present application relates to a method for extracting coenzyme Q10 and a phospholipid from a coenzyme Q10 fermentation bacterium powder. The method is characterized in that the fermentation bacterium powder of a coenzyme Q10 production strain is subjected to extraction with a mixed solvent of which the three-dimensional Hansen solubility parameter is between 21 and 23 (J/cm3)1/2 and the hydrogen bonding solubility parameter thereof is between 10 and 12 (J/cm3)1/2. The present invention can efficiently extract two products, namely coenzyme Q10 and a phospholipid, from the coenzyme Q10 fermentation bacterium powder; the process thereof is highly operable, easy to be industrialized, and can provide a product with high purity and yield, having great economic benefit.Type: ApplicationFiled: July 12, 2018Publication date: November 5, 2020Inventors: Woyuan LI, Hong YIN, Zhirong CHEN, Baishan HU, Guiyang ZHOU, Hangjun DENG, Ming LIAN, Xiongwei ZHANG, Qichuan LI, Jiang ZHAO
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Patent number: 10774350Abstract: The present application relates to a method for fermentative production of oxidized coenzyme Q10 and high-content oxidized coenzyme Q10 prepared therefrom. For the method for fermentative production of oxidized coenzyme Q10, in a fermentation process of a production strain, the oxidation-reduction potential (ORP) of a fermentation broth is controlled to be ?50 to 300 Mv, and preferably the oxidation-reduction potential (ORP) of the fermentation broth is controlled to be 50 to 200 mV. By controlling the ORP of the fermentation broth, the method for fermentative production of oxidized coenzyme Q10 enables the oxidized coenzyme Q10 content in the coenzyme Q10 produced by microorganisms to reach 96% or more, and the product is substantially composed of a single component, which makes post-treatment more convenient.Type: GrantFiled: June 25, 2018Date of Patent: September 15, 2020Assignees: ZHEJIANG NHU COMPANY LTD., ZHEJIANG UNIVERSITY, HEILONGJIANG NHU BIOTECHNOLOGY COMPANY LTD., SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD.Inventors: Shenfeng Yuan, Hongwei Yu, Zhaofeng Chen, Yongqiang Zhu, Yi Min, Yong Li, Baishan Hu, Guisheng Qiu, Kai Yu
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Publication number: 20200029596Abstract: The present invention discloses a fat-soluble nutrient microcapsule and a preparation method thereof. The fat-soluble nutrient microcapsule comprises the following components in percentage by weight: a fat-soluble nutrient (0.2-51.6%), an antioxidant (0.2-5.0%), a wall material (41.4-97.6%) and a moisture (2.0-5.0%) and the ratio of the fat-soluble nutrient that keeps active in the fat-soluble nutrient microcapsule to the fat-soluble nutrient that is initially added is 0.990-0.997:1. The preparation method of the fat-soluble nutrient microcapsule comprises an emulsification process and a granulation process, wherein the emulsification is performed in a cavitation emulsifier. By the preparation method, the nutrient active substance of the fat-soluble nutrient microcapsule has less lost and high stability.Type: ApplicationFiled: April 26, 2018Publication date: January 30, 2020Inventors: JIANDONG LI, BAISHAN HU, ZHIRONG CHEN, LIFANG SHI, QICHUAN LI, XIAOYONG ZHU, GUISHENG QIU, QILEI ZHANG, YOUMIN YANG, LINPU CAI
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Publication number: 20190194704Abstract: The present application relates to a method for fermentative production of oxidized coenzyme Q10 and high-content oxidized coenzyme Q10 prepared therefrom. For the method for fermentative production of oxidized coenzyme Q10, in a fermentation process of a production strain, the oxidation-reduction potential (ORP) of a fermentation broth is controlled to be ?50 to 300 Mv, and preferably the oxidation-reduction potential (ORP) of the fermentation broth is controlled to be 50 to 200 mV. By controlling the ORP of the fermentation broth, the method for fermentative production of oxidized coenzyme Q10 enables the oxidized coenzyme Q10 content in the coenzyme Q10 produced by microorganisms to reach 96% or more, and the product is substantially composed of a single component, which makes post-treatment more convenient.Type: ApplicationFiled: June 25, 2018Publication date: June 27, 2019Inventors: Shenfeng YUAN, Hongwei YU, Zhaofeng CHEN, Yongqiang ZHU, Yi MIN, Yong LI, Baishan HU, Guisheng QIU, Kai YU