Patents by Inventor Barbara L. Gaffney

Barbara L. Gaffney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11014956
    Abstract: The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: May 25, 2021
    Assignees: Memorial Sloan Kettering Cancer Center; The Rockefeller, University; Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Publication number: 20190330257
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: June 28, 2019
    Publication date: October 31, 2019
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, JR., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Patent number: 10385091
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: August 20, 2019
    Assignees: Memorial Sloan Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Patent number: 10131686
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: November 20, 2018
    Assignees: Memorial Sloan Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Publication number: 20180127454
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: December 8, 2017
    Publication date: May 10, 2018
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Publication number: 20180118777
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: September 28, 2017
    Publication date: May 3, 2018
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Patent number: 9840533
    Abstract: The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: December 12, 2017
    Assignees: Memorial Sloan Kettering Cancer Center, Rutgers, The State University of New Jersey, The Rockefeller University, University of Bonn
    Inventors: Dinshaw Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Patent number: 9315523
    Abstract: Provided herein are compounds of formula Ia: and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula Ia, processes for preparing compounds of formula Ia, intermediates useful for preparing compounds of formula Ia and therapeutic methods using compounds of formula Ia.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: April 19, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Roger A. Jones, Barbara L. Gaffney
  • Publication number: 20160068560
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: April 29, 2014
    Publication date: March 10, 2016
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: Dinshaw Patel, Thomas Tuschl, Manuel Ascano, JR., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Patent number: 9090646
    Abstract: The invention provides new biotinylated compounds and methods for their use.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: July 28, 2015
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Roger A. Jones, Barbara L. Gaffney
  • Publication number: 20150158886
    Abstract: Provided herein are compounds of formula Ia: and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula Ia, processes for preparing compounds of formula Ia, intermediates useful for preparing compounds of formula Ia and therapeutic methods using compounds of formula Ia.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 11, 2015
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Roger A. Jones, Barbara L. Gaffney
  • Publication number: 20140155345
    Abstract: The invention provides new biotinylated compounds and methods for their use.
    Type: Application
    Filed: December 4, 2013
    Publication date: June 5, 2014
    Applicant: Rutgers, the State University of New Jersey
    Inventors: Roger A. Jones, Barbara L. Gaffney
  • Publication number: 20120178710
    Abstract: The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series of seven phosphorothioate derivatives that includes diastereomers of mono-, di-, and trithiophosphates.
    Type: Application
    Filed: July 1, 2010
    Publication date: July 12, 2012
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Roger A. Jones, Barbara L. Gaffney
  • Patent number: 5412088
    Abstract: The following species of N6-activated guanosine derivatives are disclosed:2-N-trifluoroacetamido-6-(4-nitrophenoxy)-9-(2-deoxy-beta-D-erythro-pentofu ranosyl)purine2-N-trifluoroacetamido-6-pentafluorophenoxy-9-(2-deoxy-beta-D-erythro-pento furanosyl)purine6-dimethylpyridinium-9-(2-deoxy-beta-D-erythropentofuranosyl)purineThese guanosine compounds are useful as precursors in the synthesis of a wide variety of antiviral and anticancer nucleosides such as 2-amino-2-deoxyadenosine or 6-thio-deoxyguanosine. Also disclosed are oligonucleotides containing the above nucleosides which are precursors to modified oligonucleotides which are useful as hybridization probes.
    Type: Grant
    Filed: April 3, 1992
    Date of Patent: May 2, 1995
    Assignee: Rutgers, The State University
    Inventors: Roger A. Jones, Reza Fathip, Barbara L. Gaffney