Patents by Inventor Barbara Pio

Barbara Pio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrazoles
    Patent number: 7417046
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: August 26, 2008
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Mary Pat Beavers, J. Guy Breitenbucher, Hui Cai, James P. Edwards, Cheryl A. Grice, Darin J. Gustin, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Kevin L. Tays, Jianmei Wei
  • Substituted pyrazoles
    Patent number: 7393850
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: July 1, 2008
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Mary Pat Beavers, J. Guy Breitenbucher, Hui Cai, James P. Edwards, Cheryl A. Grice, Darin J. Gustin, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Kevin L. Tays, Jianmei Wei
  • Substituted pyrazoles
    Patent number: 7388011
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: June 17, 2008
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Mary Pat Beavers, J. Guy Breitenbucher, Hui Cai, James P. Edwards, Cheryl A. Grice, Darin J. Gustin, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Kevin L. Tays, Jianmei Wei
  • Method for treating allergies using substituted pyrazoles
    Patent number: 7332494
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: February 19, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: J. Guy Breitenbucher, Hui Cai, James P. Edwards, Cheryl A. Grice, Yin Gu, Darin J. Gustin, Lars Karlsson, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Siquan Sun, Kevin L. Tays, Robin L. Thurmond, Jianmei Wei
  • Substituted pyrazoles
    Patent number: 7309703
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: December 18, 2007
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Mary Pat Beavers, J. Guy Breitenbucher, Hui Cai, James P. Edwards, Cheryl A. Grice, Darin J. Gustin, Haripada Khatuya, Steven P. Meduna, Barbara A. Pio, Kevin L. Tays, Jianmei Wei
  • Substituted pyrazoles
    Patent number: 7265102
    Abstract: Substituted pyrazoles of general formula methods of manufacturing them, compositions containing them, and methods of using them to, for example, treat autoimmune diseases mediated by cathepsin S, and inhibit cathepsin S activity, are described.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: September 4, 2007
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Hui Cai, James P. Edwards, Steven P Meduna, Barbara A. Pio, Jianmei Wei
  • Androgen receptor modulator compounds and methods
    Publication number: 20070167445
    Abstract: Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.
    Type: Application
    Filed: January 25, 2006
    Publication date: July 19, 2007
    Inventors: Robert Higuchi, Kristen Arienti, Neelakandha Mani, Barbara Pio, Lin Zhi, Penghui Chen, Thomas Caferro
  • Substituted pyrazoles and methods of treatment with substituted pyrazoles
    Publication number: 20070117785
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases or allergic conditions, including atopic allergic conditions, mediated by cathepsin S are described.
    Type: Application
    Filed: October 4, 2006
    Publication date: May 24, 2007
    Inventors: Christopher Butler, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Joanne Quan, Clark Sehon, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei, Ann Welton
  • Method for treating allergies using substituted pyrazoles
    Publication number: 20070105841
    Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 10, 2007
    Inventors: J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Yin Gu, Darin Gustin, Lars Karlsson, Haripada Khatuya, Steven Meduna, Barbara Pio, Siquan Sun, Kevin Tays, Robin Thurmond, Jianmei Wei
  • Heterocyclic amide derivatives as RXR agonists for the treatment of dyslipidemia, hypercholesterolemia and diabetes
    Publication number: 20070078129
    Abstract: The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating RXR mediated disorders. More particularly, the compounds of the present invention are RXR agonists useful for treating RXR mediated disorders.
    Type: Application
    Filed: September 25, 2006
    Publication date: April 5, 2007
    Inventors: Bharat Lagu, Rimma Lebedev, Barbara Pio
  • DIHYDRO-[1H]-QUINOLIN-2-ONE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES
    Publication number: 20070078160
    Abstract: The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating RXR mediated disorders. More particularly, the compounds of the present invention are RXR agonists useful for treating RXR mediated disorders.
    Type: Application
    Filed: September 25, 2006
    Publication date: April 5, 2007
    Inventors: Bharat Lagu, Rimma Lebedev, Barbara Pio
  • Substituted pyrazoles
    Publication number: 20070021437
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 25, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070010530
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 11, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070004754
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070004738
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070004755
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20070004747
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Mary Beavers, J. Breitenbucher, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Kevin Tays, Jianmei Wei
  • Bicyclic androgen and progesterone receptor modulator compounds and methods
    Patent number: 6964973
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: November 15, 2005
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Barbara Pio, Luc Farmer
  • Substituted pyrazoles
    Publication number: 20050245576
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
    Type: Application
    Filed: June 30, 2005
    Publication date: November 3, 2005
    Inventors: Christopher Butler, Hui Cai, James Edwards, Cheryl Grice, Darin Gustin, Haripada Khatuya, Steven Meduna, Barbara Pio, Clark Sehon, Kevin Tays, Jianmei Wei
  • Substituted pyrazoles
    Publication number: 20050234102
    Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
    Type: Application
    Filed: June 8, 2005
    Publication date: October 20, 2005
    Inventors: Hui Cai, James Edwards, Steven Meduna, Barbara Pio, Jianmei Wei