Abstract: The invention provides a combination, kit or composition comprising: (i) one or more nitrite salt; (ii) a proton source comprising one or more acid selected from organic carboxylic acids and organic non-carboxylic reducing acids; and (iii) one or more organic polyol. On reaction of the one or more nitrite salt with the proton source in the presence of the one or more organic polyol, the combination, kit or composition provides reaction products which include nitric oxide, optionally other oxides of nitrogen and/or optionally precursors thereof and which are useful, for example, in the treatment of various disorders.

Abstract: This invention is directed to a medical device having an elongate shaft having a distal end and a controller coupled to the shaft. A control member can extend through at least part of the elongate shaft and at least part of the controller, wherein the control member in a tensioned configuration can be moveable by the controller to control the distal end of the shaft and the control member can be slack in an untensioned configuration. A tensioning mechanism can be configured to move relative to at least one of the elongate shaft and the controller to tension the control member and automatically lock the control member in the tensioned configuration.

Abstract: A gas dispensing system for a beverage system is disclosed herein. The gas dispensing system can releasably secure a gas canister or other gas source for release of pressurized gas therein to the beverage system. In an embodiment, the gas dispensing system includes a distribution body that can articulate between a loading position and a dispensing position. In the loading position, a gas canister can be releasably secured within the system. As the distribution body is moved into the dispensing position, a puncture mechanism can be moved further into the distribution body, puncturing the gas canister for release of pressurized gas. The distribution body can be fluidically coupled with a valve or other flow control element of the beverage machine, allowing for controlled entry of the pressurized gas into the system.

Abstract: A combination, kit or composition is disclosed, comprising: (i) one or more nitrite salt; (ii) a proton source comprising one or more acid selected from organic carboxylic acids and organic non-carboxylic reducing acids; and (iii) one or more organic polyol. On reaction of the one or more nitrite salt with the proton source in the presence of the one or more organic polyol, the combination, kit or composition provides reaction products which include nitric oxide, optionally other oxides of nitrogen and/or optionally precursors thereof and which are useful in the treatment of various disorders via delivery of the combination or composition or the nitric oxide, optionally other oxides of nitrogen and/or optionally precursors thereof to a subject via the respiratory tract.

Abstract: The present invention provides antibodies that bind human Anx-A1 for use in the treatment of cancer, including drug-resistant cancer. Kits and products for this use are also provided.

Abstract: The present invention relates to an isolated specific binding molecule which binds human Anx-A1 and comprises the complementarity-determining regions (CDRs) VLCDR1, VLCDR2, VLCDR3, VHCDR1, VHCDR2 and VHCDR3, wherein each of said CDRs has an amino acid sequence as follows: VLCDR1 has the sequence set forth in SEQ ID NO: 1, 36 or 37; VLCDR2 has the sequence set forth in SEQ ID NO: 2; VLCDR3 has the sequence set forth in SEQ ID NO: 3; VHCDR1 has the sequence set forth in SEQ ID NO: 4; VHCDR2 has the sequence set forth in SEQ ID NO: 5; and VHCDR3 has the sequence set forth in SEQ ID NO: 6; or, for each sequence, an amino acid sequence with at least 85% sequence identity thereto. The specific binding molecule disclosed is therapeutically useful and in particular may be used in therapy for T-cell mediated diseases, including autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, obsessive compulsive disorder (OCD), and OCD-related diseases, such as anxiety disorders.

Abstract: A diagnostic transdermal patch which utilizes a microneedle array and an integrated biochemical assay to detect the presence of biomolecules which are associated with a specific condition or disease, such as mild traumatic brain injury (MTBI).

Abstract: A gas demand device cycles through five successive operation phases: gas is prevented from flowing through the timing gas and demand gas flow paths; gas is allowed to flow through the timing gas flow path and gas is prevented from flowing through the demand gas flow path; gas is allowed to flow through the timing gas and demand gas flow paths; gas is prevented from flowing through the timing gas flow path and gas is allowed to flow through the demand gas flow path; and gas is prevented from flowing through the timing gas and demand gas flow paths.

Abstract: Described herein is a beverage system that is configured to produce beverages having different characteristics, such as different levels of carbonation including producing substantially non-carbonated beverages and carbonated beverages with a single machine. The beverage system includes a beverage appliance and a beverage container. The beverage container includes a beverage material, which can include a flavoring ingredient for a target beverage. The beverage appliance is used to access the beverage material from the beverage container and produce the target beverage. The beverage appliance and beverage container are adaptable to produce the target beverage having any of a range of carbonation levels or other characteristics.

Abstract: The present invention relates to an isolated specific binding molecule which binds human Anx-A1 and comprises the complementarity-determining regions (CDRs) VLCDR1, VLCDR2, VLCDR3, VHCDR1, VHCDR2 and VHCDR3, wherein each of said CDRs has an amino add sequence as follows: VLCDR1 has the sequence set forth in SEQ ID NO: 1, 36 or 37; VLCDR2 has the sequence set forth in SEQ ID NO: 2; VLCDR3 has the sequence set forth in SEQ ID NO: 3; VHCDR1 has the sequence set forth in SEQ ID NO: 4; VHCDR2 has the sequence set forth in SEQ ID NO: 5; and VHCDR3 has the sequence set forth in SEQ ID NO: 6; or, for each sequence, an amino acid sequence with at least 85% sequence identity thereto. The specific binding molecule disclosed is therapeutically useful and in particular may be used in therapy for T-cell mediated diseases, including autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, obsessive compulsive disorder (OCD), and OCD-related diseases, such as anxiety disorders.

Abstract: A spill-resistant and moisture absorbing device comprises a lid, a cover having a wall with an opening and attachably connected to the lid, a tray having an upper side and an underside and attachably connected to the cover from an upper side of the tray, and a basin having a cavity for collection of brine and attachably connected from the underside of the tray. The tray comprises a holder for holding a tablet.

Abstract: A gas dispensing system for a beverage system is disclosed herein. The gas dispensing system can releasably secure a gas canister or other gas source for release of pressurized gas therein to the beverage system. In an embodiment, the gas dispensing system includes a distribution body that can articulate between a loading position and a dispensing position. In the loading position, a gas canister can be releasably secured within the system. As the distribution body is moved into the dispensing position, a puncture mechanism can be moved further into the distribution body, puncturing the gas canister for release of pressurized gas. The distribution body can be fluidically coupled with a valve or other flow control element of the beverage machine, allowing for controlled entry of the pressurized gas into the system.

Abstract: A system or method for carbonating a liquid includes receiving, in a sealed container of a carbonator of a drink dispenser system, a predetermined amount of liquid, identifying a predetermined carbonation level associated with a flavoring material, and setting a target pressure of the sealed container based on the predetermined carbonation level. The target pressure is selected from a plurality of different target pressures. The system or method also can include releasing pressurized carbon dioxide from a carbon dioxide source into the sealed container holding the predetermined amount of the liquid therein until an internal pressure of the sealed container is substantially equal to the target pressure. The system or method can also include dispensing, into a drink container, the flavoring material and the liquid from the sealed container of the carbonator.

Abstract: A moisture absorber is provided having a container and a lid having a top surface and a bottom surface, the lid having an edge for attachment to the container, and a vapor transmission barrier attached to the bottom surface of the lid. A moisture absorber is provided comprising a container having a floor and at least one upstanding side wall from the floor of the container, the upstanding side wall having a lip and the container having at least one upstanding support extending upward from the floor of the container for supporting a removable tray having a plurality of openings; a lid having a top surface and a bottom surface, the lid having an edge for attachment to the lip of the upstanding side wall of the container; and a vapor transmission barrier attached to the bottom surface of the lid.

Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions; wherein the layer containing a nitrite and/or the hydrogel comprises a pharmaceutically active agent. The invention also provides the use of a system of the invention in medicine, and in the treatment of pain.

Abstract: Low Latency Interconnect Integrated Event Handling has been disclosed. In one implementation a hardware based interrupt controller coupled with a hardware based event queue manager, dedicated hardware based queues, and processor instruction extensions allows for off-loading event processing from an operating system thereby dramatically lowering wasted processor cycles while speeding up event processing.