Patents by Inventor Barton F. Haynes

Barton F. Haynes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210246194
    Abstract: The present invention is directed to optimized HIV-1 gp41-Binding Molecules having reduced immunogenicity. More specifically, the invention relates to optimized gp41-Binding Molecules that comprise a gp41-binding Variable Light Chain (VL) Domain and/or a gp41-binding Variable Heavy Chain (VH) Domain that has/have been optimized to reduce the immunogenicity of such Domain(s) upon administration to a recipient subject. The invention particularly pertains to gp41-Binding Molecules that are multispecific gp41-Binding Molecules (including bispecific diabodies (including DART® diabodies), BiTE®s, bispecific antibodies, trivalent binding molecules (including TRIDENT™ molecules), etc.) that comprise: (i) such optimized gp41-binding Variable Domain(s) and (ii) a domain capable of binding to an epitope of a molecule present on the surface of an effector cell.
    Type: Application
    Filed: May 13, 2019
    Publication date: August 12, 2021
    Applicants: MacroGenics, Inc., Duke University
    Inventors: Chia-Ying Kao Lam, Gundo Diedrich, Jeffrey Lee Nordstrom, Liqin Liu, Leslie S. Johnson, Scott Koenig, Barton F. Haynes, Guido Ferrari
  • Patent number: 11077130
    Abstract: The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: August 3, 2021
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori
  • Patent number: 11071783
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: July 27, 2021
    Assignees: DUKE UNIVERSITY, UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody, LaTonya Williams, Kevin J. Wiehe, Gilad Adi Ofek
  • Patent number: 11053285
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: July 6, 2021
    Assignees: Duke University, THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY, Children's Medical Center Corporation
    Inventors: Jerome Kim, Stephen Harrison, Barton F. Haynes, Georgia D. Tomaras, Nelson Michael
  • Publication number: 20210187091
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 3, 2017
    Publication date: June 24, 2021
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Bette T. KORBER, Peter T. HRABER, Kevin SAUNDERS
  • Publication number: 20210139544
    Abstract: The invention is directed to mosaic HIV-1 envelopes, and methods of using the same to induce ADCC responses.
    Type: Application
    Filed: October 2, 2018
    Publication date: May 13, 2021
    Inventors: Bette Korber, Sandrasegaram Gnanakaran, Guido Ferrari, Barton F. Haynes
  • Patent number: 10968255
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 6, 2021
    Assignees: Duke University, Triad National Security, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber, Kevin Saunders
  • Publication number: 20210095021
    Abstract: The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.
    Type: Application
    Filed: June 22, 2020
    Publication date: April 1, 2021
    Applicants: MacroGenics, Inc., Duke University
    Inventors: Scott Koenig, Leslie S. Johnson, Chia-Ying Kao Lam, Liqin Liu, Jeffrey Lee Nordstrom, Barton F. Haynes, Guido Ferrari
  • Patent number: 10946090
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 16, 2021
    Assignees: Duke University, The University of Alabama at Birmingham Research Foundation, Triad National Security, LLC
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise L. Monti, Ying Ying Li, Julie Decker, Hua-Xin Liao
  • Publication number: 20210061891
    Abstract: Disclosed herein are Complement factor H (CFH) antibodies and methods of using the antibodies.
    Type: Application
    Filed: October 21, 2020
    Publication date: March 4, 2021
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, Michael Anthony Moody
  • Publication number: 20210052720
    Abstract: The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1 V2 env region of clade C HIV-1.
    Type: Application
    Filed: April 29, 2020
    Publication date: February 25, 2021
    Inventors: Barton F. Haynes, Bette T. Korber
  • Patent number: 10906941
    Abstract: The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: February 2, 2021
    Inventors: Jerome Kim, Morgane Rolland, Bette T. Korber, Barton F. Haynes
  • Patent number: 10865238
    Abstract: Disclosed herein are Complement factor H (CFH) antibodies and methods of using the antibodies.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: December 15, 2020
    Assignee: Duke University
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, Michael Anthony Moody
  • Patent number: 10849970
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 1, 2020
    Assignees: Duke University, Triad National Security, LLC, The Trustees of The University of Pennsylvania, Trustees of Boston University, The Government of The United States of America as Represented by the Secretary of the Department of Health and Human Services, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barton F. Haynes, Hua-Xin Liao, Rebecca M. Lynch, Tongqing Zhou, Feng Gao, Scott Boyd, George M. Shaw, Beatrice H. Hahn, Thomas B. Kepler, Bette T. Korber, Peter Kwong, John R. Mascola
  • Patent number: 10835599
    Abstract: The present invention relates, in general, to an HIV-1 vaccine and, in particular, to a B cell lineage-based vaccination protocol.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: November 17, 2020
    Assignees: DUKE UNIVERSITY, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Barton F. Haynes, Garnett Kelsoe, Stephen Harrison, Thomas B. Kepler
  • Publication number: 20200354439
    Abstract: The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecule and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells within the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28 or CH44.
    Type: Application
    Filed: June 2, 2020
    Publication date: November 12, 2020
    Applicants: Duke University, MacroGenics, Inc., The University of North Carolina at Chapel Hill
    Inventors: Barton F. HAYNES, Guido FERRARI, Scott KOENIG, Leslie S. JOHNSON, Chia-Ying Kao LAM, Julia A. SUNG, David M. MARGOLIS, Liqin LIU, Jeffrey Lee NORDSTROM
  • Patent number: 10730947
    Abstract: The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: August 4, 2020
    Assignees: MacroGenics, Inc., Duke University
    Inventors: Scott Koenig, Leslie S. Johnson, Chia-Ying Kao Lam, Liqin Liu, Jeffrey Lee Nordstrom, Barton F. Haynes, Guido Ferrari
  • Patent number: 10717778
    Abstract: The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28, or CH44.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: July 21, 2020
    Assignees: DUKE UNIVERSITY, MACROGENICS, INC., THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Barton F. Haynes, Guido Ferrari, Scott Koenig, Leslie S. Johnson, Chia-Ying Kao Lam, Julia A. Sung, David M. Margolis, Liqin Liu, Jeffrey Lee Nordstrom
  • Publication number: 20200113997
    Abstract: In certain aspects the invention provides HV-1 immunogens, including envelopes (CH0848) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 2, 2018
    Publication date: April 16, 2020
    Inventors: Barton F. HAYNES, Kevin O. SAUNDERS
  • Publication number: 20200095646
    Abstract: The invention is directed to methods, reagents and kits for detecting incident HIV-1 infection.
    Type: Application
    Filed: July 5, 2017
    Publication date: March 26, 2020
    Inventors: Georgia Tomaras, Kelly Seaton, Xiaoying Shen, Nicole Yates, Hua-xin Liao, Barton F. Haynes, Nathan Vandergrift, Wes Rountree, John Bainbridge