Patents by Inventor Barton F. Haynes

Barton F. Haynes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TRANSIENT IMMUNE RESPONSE MODULATION DURING VACCINATION
    Publication number: 20170216426
    Abstract: In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogenic compositions and methods comprise at least one agent for transient immune response modulation during vaccination.
    Type: Application
    Filed: September 28, 2015
    Publication date: August 3, 2017
    Inventors: Barton F. HAYNES, Garnett KELSOE, Masayuki KURAOKA, M. Anthony MOODY, Hua-Xin LIAO, Laurent VERKOCZY
  • Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin
    Patent number: 9718873
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: August 1, 2017
    Assignees: Duke University, Children's Medical Center Corporation
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, M. A. Moody, Thomas B. Kepler, Aaron G. Schmidt
  • Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies
    Patent number: 9717789
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: August 1, 2017
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • MOSAIC HIV-1 SEQUENCES AND USES THEREOF
    Publication number: 20170107260
    Abstract: The invention is directed to mosaic HIV 1 genes designed to induce T-cell responses.
    Type: Application
    Filed: March 25, 2015
    Publication date: April 20, 2017
    Inventors: Barton F. Haynes, Bette T. Korber
  • LIPOSOME-PEPTIDE CONJUGATE AND METHOD OF USING SAME TO INDUCE PRODUCTION OF ANTI-HIV ANTIBODIES
    Publication number: 20170106080
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: June 28, 2016
    Publication date: April 20, 2017
    Inventors: Barton F. HAYNES, S. Munir ALAM, Hua-Xin LIAO
  • SWARM IMMUNIZATION WITH ENVELOPES FROM CH505
    Publication number: 20170080082
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 23, 2017
    Inventors: Barton F. HAYNES, Feng GAO, Bette T. KORBER, Peter T. HRABER
  • MPER-LIPOSOME CONJUGATES AND USES THEREOF
    Publication number: 20170014503
    Abstract: The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.
    Type: Application
    Filed: September 29, 2014
    Publication date: January 19, 2017
    Inventors: Barton F. HAYNES, Bette T. KORBER, S. Munir ALAM
  • HIV-1 MOTHER-TO-CHILD TRANSMISSION CORRELATES OF PROTECTION AND VACCINE
    Publication number: 20160339051
    Abstract: The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
    Type: Application
    Filed: September 26, 2014
    Publication date: November 24, 2016
    Inventors: Barton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori
  • Nucleic acids encoding mosaic HIV-1 gag proteins
    Patent number: 9492532
    Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 15, 2016
    Assignees: DUKE UNIVERSITY, U. OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, BETH ISRAEL DEACONESS MEDICAL CENTER, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS
    Publication number: 20160317648
    Abstract: The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1 V2 env region of clade C HIV-1.
    Type: Application
    Filed: December 18, 2014
    Publication date: November 3, 2016
    Inventors: Barton F. HAYNES, Bette T. KORBER
  • INHIBITORS OF COMPLEMENT FACTOR H
    Publication number: 20160311893
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Application
    Filed: June 7, 2014
    Publication date: October 27, 2016
    Inventors: Edward F. Patz, JR., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, Anthony M. Moody
  • METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES
    Publication number: 20160271244
    Abstract: The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.
    Type: Application
    Filed: February 29, 2016
    Publication date: September 22, 2016
    Inventors: Barton F. Haynes, Hua-Xin Liao, Georgia Tomaras, Thomas B. Kepler, Kwan-Ki Hwang, S. Munir Alam, Yang Liu, T. Matt Holl, Guang Yang, Garnett Kelsoe, Mattia Bonsignori
  • HUMAN MONOCLONAL ANTIBODIES
    Publication number: 20160244510
    Abstract: The present invention relates, in general, to HIV-1-reactive antibodies and, in at least certain specific embodiments, to broadly neutralizing antibodies (bnAbs) (and fragments and derivatives thereof) and to compositions comprising same. The invention further relates to methods of using such bnAbs (and fragments and derivatives thereof) and compositions in immunotherapy regimens (e.g., passive immunotherapy regimens). The antibodies (and fragments and derivatives thereof) disclosed herein can also be used in methods of identifying candidate immunogens for use in inducing an immune response against HIV-1 in a mammal (e.g., a human). The invention also relates to such methods and to immunogens so identified.
    Type: Application
    Filed: September 26, 2014
    Publication date: August 25, 2016
    Inventors: M Anthony Moody, Hua-Xin Liao, Barton F Haynes, Lynn Morris
  • Methods for the induction of broadly anti-HIV-1 neutralizing antibody responses employing liposome-MPER peptide compositions
    Patent number: 9402917
    Abstract: The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: August 2, 2016
    Assignee: DUKE UNIVERSITY
    Inventors: S. Munir Alam, Barton F. Haynes, Moses D. Sekaran, Georgia Tomaras, Xiaoying Shen
  • Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies
    Patent number: 9402893
    Abstract: The present invention relates to a method of inducing the production of anti-HIV antibodies. The method comprises administering at least one liposome-peptide conjugate, wherein the peptide comprises a membrane proximal external region (MPER) epitope.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: August 2, 2016
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • USE OF TETRAHYDROINDAZOLYLBENZAMIDE AND TETRAHYDROINDOLYLBENZAMIDE DERIVATIVES FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS)
    Publication number: 20160143884
    Abstract: Provided are methods of treating or inhibiting Human Immunodeficiency Virus (HIV) infection, or treating or inhibiting Acquired Human Immunodeficiency Syndrome (AIDS) in a subject in need thereof, comprising administering an Hsp90 inhibitor in a therapeutically effective amount.
    Type: Application
    Filed: November 25, 2015
    Publication date: May 26, 2016
    Inventors: Everardus O.M. Orlemans, Barton F. Haynes, Guido Ferrari, Timothy Haystead, Jesse John Kwiek
  • POLYVALENT HIV-1 IMMUNOGEN
    Publication number: 20160115205
    Abstract: The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.
    Type: Application
    Filed: April 15, 2014
    Publication date: April 28, 2016
    Inventors: Jerome Kim, Morgane Rolland, Bette T. Korber, Barton F. Haynes
  • V3 IMMUNOGENS
    Publication number: 20160106827
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a vaccine for HIV-1, comprising synthetic V3 glycopeptides, and to methods of making and using same.
    Type: Application
    Filed: April 15, 2014
    Publication date: April 21, 2016
    Inventors: Barton F. Haynes, Hua-xin Liao, Samuel Danishefsky, Peter Park, Joseph Sodroski, Baptiste Aussedat, Yusuf Vohra
  • POLYVALENT VACCINE
    Publication number: 20160067329
    Abstract: The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.
    Type: Application
    Filed: April 17, 2015
    Publication date: March 10, 2016
    Inventors: Bette T. KORBER, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
  • RECOMBINANT PRODUCTION OF HIV-1 ENVELOPE GLYCOPROTEINS
    Publication number: 20160039885
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to methods of producing HIV-1 envelope (Env) proteins, and subunits thereof, and to constructs suitable for use in such methods.
    Type: Application
    Filed: April 1, 2014
    Publication date: February 11, 2016
    Inventors: Barton F. Haynes, Hua-Xin Liao, Jae-sung Yu