Patents by Inventor Bassam B. Damaj

Bassam B. Damaj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180333377
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: December 15, 2017
    Publication date: November 22, 2018
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. FRANK, Richard MARTIN, Bassam B. DAMAJ
  • Patent number: 9855231
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: January 2, 2018
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Patent number: 9517218
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: December 13, 2016
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20160331761
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: July 29, 2016
    Publication date: November 17, 2016
    Applicant: Nexmed Holdings, Inc.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20160220524
    Abstract: Compositions containing a small molecule therapeutic and an alkyl N,N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N,N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutic.
    Type: Application
    Filed: January 29, 2015
    Publication date: August 4, 2016
    Inventors: Bassam B. Damaj, Richard M. Martin
  • Publication number: 20160081954
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: January 7, 2015
    Publication date: March 24, 2016
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20150265709
    Abstract: Therapeutic peptide compositions comprise a therapeutic peptide, such as insulin, together with an alkyl N,N-disubstituted amino acetate, such as dodecyl 2-(N,N-dimethylamino)propionate.
    Type: Application
    Filed: June 4, 2015
    Publication date: September 24, 2015
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Bassam B. Damaj, Richard Martin
  • Publication number: 20150079163
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 19, 2015
    Inventors: Bassam B. DAMAJ, Richard Martin
  • Patent number: 8962595
    Abstract: Compositions containing a small molecule therapeutic and an alkyl N,N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N,N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutic.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: February 24, 2015
    Assignee: Nexmed Holdings, Inc.
    Inventors: Bassam B. Damaj, Richard Martin
  • Patent number: 8940794
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: January 27, 2015
    Assignee: Nexmed Holdings, Inc.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20140357713
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Application
    Filed: May 7, 2014
    Publication date: December 4, 2014
    Applicant: NexMed Holdings, Inc.
    Inventors: Bassam B. Damaj, Richard Martin
  • Patent number: 8900625
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 2, 2014
    Assignee: Nexmed Holdings, Inc.
    Inventors: Bassam B. Damaj, Richard M. Martin
  • Publication number: 20140350482
    Abstract: The present invention relates to methods for reconstituting and relates to reconstitution devices suitable for reconstituting many different materials. Furthermore, the present invention includes methods of treatment and methods of use related to a reconstitution device or apparatus. Some embodiments are suitable for reconstituting small amounts of a pharmaceutical compositions and using the pharmaceutical composition for the treatment of sexual dysfunction.
    Type: Application
    Filed: July 6, 2012
    Publication date: November 27, 2014
    Inventors: Bassam B. Damaj, Richard Martin, Michael Mueller, Daniel W. Frank
  • Publication number: 20140200274
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: April 6, 2012
    Publication date: July 17, 2014
    Applicant: Nexmed Holdings, Inc
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20140170207
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Application
    Filed: March 15, 2013
    Publication date: June 19, 2014
    Inventors: Bassam B. Damaj, Richard M. Martin
  • Patent number: 8697629
    Abstract: A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3, an ?6 polypeptide, or an isolated polypeptide consisting essentially of the Link region of human CD44 as indicated in FIG. 17 to modulate a FAK signal transduction pathway for a sufficient period of time to treat the disease. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes measuring the effect of these polypeptides on FAK signal transduction activity; wherein a change in FAK signal transduction activity is indicative of said aberrant cell migration or invasion. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes imaging FAK signal transduction activity in the presence of these polypeptides.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: April 15, 2014
    Assignee: Angstrom Pharmaceuticals, Inc.
    Inventors: Malcolm Finlayson, Bassam B. Damaj
  • Publication number: 20130267562
    Abstract: 2R-dodecyl 2-(N,N dimethylamino)-propionate (R-DDAIP) provides an unexpectedly improved activity in facilitating transport of a pharmaceutically active compound across biological membranes and tissues, compared to S-DDAIP of the same enantiomeric purity, or racemic DDAIP. Purified S-DDAIP is also provided.
    Type: Application
    Filed: November 30, 2011
    Publication date: October 10, 2013
    Applicant: NEXMED HOLDINGS, INC
    Inventors: Bassam B. Damaj, Richard Martin
  • Publication number: 20130209393
    Abstract: Therapeutic peptide compositions comprise a therapeutic peptide, such as insulin, together with an alkyl N,N-disubstituted amino acetate, such as dodecyl 2-(N,N-dimethylamino) propionate.
    Type: Application
    Filed: May 4, 2011
    Publication date: August 15, 2013
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Bassam B. Damaj, Richard Martin
  • Publication number: 20130210766
    Abstract: Compositions containing a small molecule therapeutic and an alkyl N,N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N,N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutic.
    Type: Application
    Filed: May 4, 2011
    Publication date: August 15, 2013
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Bassam B. Damaj, Richard Martin
  • Publication number: 20130178463
    Abstract: A buccal delivery system is disclosed suitable for delivery of a therapeutic agent to the oral cavity of a patient. The delivery system comprises a matrix for containing and releasing the therapeutic agent into the oral cavity and an alkyl N,N-disubstituted amino acetate in said matrix. A particularly preferred delivery system comprises a matrix containing an effective amount of therapeutic agent together with an alkyl N,N-disubstituted amino acetate, such as dodecyl 2-(N,N-dimethylamino) propionate salt.
    Type: Application
    Filed: September 23, 2011
    Publication date: July 11, 2013
    Applicants: Rutgers, The State University of New Jersey, Nexmed Holdings, Inc.
    Inventors: Bassam B. Damaj, Richard Martin, Bozena Michniak-Kohn, Long-Sheng Hu